Article
  • In Vitro and in Vivo Studies on Antithrombogenicity of γ-Benzyl L-Glutamate-Propylene Oxide Block Copolymer
  • Cho CS, Song SC, Kim JO, Kim SS, Ryang DW, Kim KY, Sung YK, Yang HH, Kim SW
  • γ-벤질 L-글루타메이트/프로필렌 옥사이드 블록 공중합체의 항혈전성에 관한 in vitro와 in vivo에서의 연구
  • 조종수, 송수창, 김주오, 김상수, 양동욱, 김계용, 성용길, 양흥현, 김성완
Abstract
In vitro and in vivo antithrombogenicity of poly(γ-benzy1 L-glutamate)/poly( propylene oxide) block copolymer was studied. For in vitro evaluation of platelet adhesion on block copolymer surfaces, a microsphere column method was used. For in vivo evaluation of the antithrombogenicity of copolymer surfaces, small diameter(I.D. : 1.66mm) catheter precoated with copolymer was implanted in dogs to determine the mean thrombus weight. In vitro test showed that platelet adhesion was suppressed on block copolymers having microphase-separated structure. In vitro test showed that block copolymer surface exhibited excellent antithrombogenicity as compared with polyurethane catheter.

폴리 γ-벤질 L-글루타메이트/폴리 프로필렌 옥사이드 블록 공중합체의 항혈전성에 대하여 in vitro와 in vivo에서 행해졌다. in vitro에서의 혈소판 점착실험은 미립자칼림방법이 채택되었고, in vivo에서의 항혈전성은 블록공중합체로 코팅된 1.66mm의 작은 직경의 catheter을 개의 정맥혈관에 삽입한 후 일정한 시간에서 형성된 혈전량을 가지고 평가하였다. in vitro 실험결과 혈소판의 점착은 미크로상분리구조와 2차 구조를 갖는 블록공중합체에서 억제되었다. in vivo 실험결과에서도 블록공중합체에서 폴리우레탄에 비해 월등한 항혈전성을 나타내었다.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1990; 14(6): 622-629

    Published online Dec 25, 1990