Article
  • In Vitro and in Vivo Studies on Antithrombogenicity of γ-Benzyl L-Glutamate-Propylene Oxide Block Copolymer
  • Cho CS, Song SC, Kim JO, Kim SS, Ryang DW, Kim KY, Sung YK, Yang HH, Kim SW
  • γ-벤질 L-글루타메이트/프로필렌 옥사이드 블록 공중합체의 항혈전성에 관한 in vitro와 in vivo에서의 연구
  • 조종수, 송수창, 김주오, 김상수, 양동욱, 김계용, 성용길, 양흥현, 김성완
Abstract
In vitro and in vivo antithrombogenicity of poly(γ-benzy1 L-glutamate)/poly( propylene oxide) block copolymer was studied. For in vitro evaluation of platelet adhesion on block copolymer surfaces, a microsphere column method was used. For in vivo evaluation of the antithrombogenicity of copolymer surfaces, small diameter(I.D. : 1.66mm) catheter precoated with copolymer was implanted in dogs to determine the mean thrombus weight. In vitro test showed that platelet adhesion was suppressed on block copolymers having microphase-separated structure. In vitro test showed that block copolymer surface exhibited excellent antithrombogenicity as compared with polyurethane catheter.

폴리 γ-벤질 L-글루타메이트/폴리 프로필렌 옥사이드 블록 공중합체의 항혈전성에 대하여 in vitro와 in vivo에서 행해졌다. in vitro에서의 혈소판 점착실험은 미립자칼림방법이 채택되었고, in vivo에서의 항혈전성은 블록공중합체로 코팅된 1.66mm의 작은 직경의 catheter을 개의 정맥혈관에 삽입한 후 일정한 시간에서 형성된 혈전량을 가지고 평가하였다. in vitro 실험결과 혈소판의 점착은 미크로상분리구조와 2차 구조를 갖는 블록공중합체에서 억제되었다. in vivo 실험결과에서도 블록공중합체에서 폴리우레탄에 비해 월등한 항혈전성을 나타내었다.

References
  • 1. Andrade JD, Med. Instrum., 7, 110 (1973)
  •  
  • 2. Okano T, Nishiyama S, Shinohara I, Akaike T, Sakurai Y, Kataoka T, Tsuruta T, Kuwana K, Miyata S, Artif. Organs., 3(S), 253 (1979)
  •  
  • 3. Kim SW, Edert CD, Lin JY, McRea JC, ASHIO, 6, 76 (1983)
  •  
  • 4. Heyman PW, Cho CS, McRea JC, Olsen DB, Kim SW, J. Biomed. Mater. Res., 19, 419 (1985)
  •  
  • 5. Lyman DJ, Knutson K, McNeill B, Shipbtani K, Trans. Am. Soc. Artif. Int. Organs., 21, 49 (1975)
  •  
  • 6. Okano T, Nishiyama S, Shinohara I, Akaike T, Sakurai Y, Kataoka K, Tsuruta T, J. Biomed. Mater. Res., 15, 393 (1981)
  •  
  • 7. Barenberg SA, Schultz JS, Anderson JM, Geil PH, Trans. Am. Soc. Artif. Intern. Organs., 25, 159 (1979)
  •  
  • 8. Nakajima A, Kugo K, Hayashi T, Polym. J., 11, 995 (1979)
  •  
  • 9. Kang I, Ito Y, Sisido M, Imanishi Y, Polym. J., 19, 1329 (1987)
  •  
  • 10. Cho CS, Song SC, Kim SU, Ryang DW, Sung YK, Kim KY, J. Korean Soc. Medical Biological Eng., 8, 199 (1987)
  •  
  • 11. Cho CS, Kim SW, Sung YK, Kim KY, Makromol. Chem., 189, 1505 (1988)
  •  
  • 12. Fox HY, Zisman WA, J. Colloid Sci., 7, 109 (1952)
  •  
  • 13. Cho CSprivate communication
  •  
  • 14. Yui N, Kataoka K, Sakurai Y, Aoki T, Sanui K, Ogata N, Biomaterials, 9, 225 (1988)
  •  
  • 15. Yui N, Sanui K, Ogata N, Kataoka K, Okano T, Sakurai Y, J. Biomed. Mater. Res., 20, 929 (1986)
  •  
  • 16. Okano T, Uruno M, Sugiyama N, Shimada M, Shinohara I, Kataoka K, Sakurai Y, J. Biomed. Mater. Res., 20, 1035 (1986)
  •  
  • 17. Colman RW, Hirsh J, Marder VJ, Salzman JBHemostasis and Thrombosis, Lippincott, Pennsylvania (1983)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1990; 14(6): 622-629

    Published online Dec 25, 1990