Article
  • Biocompatibility of Chitosan-g-Poly(2-Hydroxyethyl Metacrylate) Membranes
  • Kim KS, Cho SH, Chun YC, Shin JS, Kim KH, Lim JS
  • Chitosan-g-Poly(2-Hydroxyethyl Methacrylate) 그라프트 공중합체막의 생체적합성
  • 김공수, 조석형, 전용철, 신재섭, 김경호, 임정수
Abstract
The membranes of acetylated chitosan-g-poly (2-hydroxyethyl methacrylate) were prepared for a skin substitute, and water content, tensile strength, elongation, permeability of water vapor and oxygen, and biodegradability of the membrane was determined. The water absorption was 130∼460%, and the tensile strength(242∼506 kg/cm2) was higher than that of the normal skin. The coefficients of water vapor and oxygen permeability were 7.4×10-9∼3.4×10-8(g·cm·cm-2s-1) and 1.4×10-8∼3.17×10-7(cm3(STP)cm·cm-2s-1cmHg-1), respectively. The biodegradation rate was fast at the initial state, but it became slower after 9∼10 days.

chitosan-poly(2-hydroxyethyl methacrylate) 그라프트 공중합체를 막으로 제조하고 그 막을 아세틸화 한 후 인공피부로서의 사용가능성을 검토하기 위하여 흡수성, 기계적 성질, 수증기 및 산소 투과성, 효소에 의한 생분해성등을 검토하였다. 흡수성은 130∼460%였고 기계적 강도는 242∼506 kg/㎠으로서 정상피부 보다 높은 값을 보였으며, 수증기 및 산소 투과성은 7.4×10-9∼3.4×10-8(g·cm·cm-2s-l)과 1.4×10-8∼3.17×l0-7 (cm3(STP) cm·cm-2s-l·cmHg-l)이었다. 효소에 의한 생분해성은 9∼10일 까지는 빠르게 증가하였으나 그 이 후는 거의 증가하지 않았다.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1990; 14(4): 385-391

    Published online Aug 25, 1990