Article
  • Drug-Release Performance of Acrylic Hydrogel Membranes Synthesized Using a Novel Cross-linker
  • Kang DY, Kwon GW, Jung KH, An SH, Kang IK
  • 새로운 가교제를 사용한 아크릴 하이드로젤 막의 합성과 약물 방출 특성
  • 강동윤, 권기완, 정경혜, 안성호, 강인규
Abstract
Hydrogel soft contact lenses have been introduced as alternatives to eye drops for ophthalmic drug delivery, because of their controllable drug loading and release behavior. In this study, acrylic hydrogel membranes were prepared by copolymerization of the novel cross-linker, ethylaluminium diacrylate (EADA), with methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA), and N-vinylpyrrolidone (NVP) in a polypropylene mold. The swelling behavior and mechanical properties of hydrogels containing the newly designed cross-linker were then investigated. Drug release performance was evaluated using a hydrophilic drug, timolol maleate, and a cyclodextrin inclusion complex of the hydrophobic drug, α-tocopherol. For comparison, hydrogels were also prepared using a conventional cross-linker, ethylene glycol dimethacrylate (EGDMA). As the results, tensile strength of the hydrogel membranes using EADA (0.168 MPa) was significantly improved compared to that of the hydrogels made with EGDMA (0.136 MPa). The hydrogel membrane cross-linked with 0.1 mol% EADA showed 66% α-tocopherol release after 30 h while the hydrogel membrane crosslinked with 0.1 mol% EGDMA showed 42% α-tocopherol release. After 2 days of incubation, human fibroblasts on the hydrogel membrane containing EADA showed significantly greater viability than those on EGDMA-containing hydrogel.

하이드로젤 콘택트렌즈는 약물 충전과 방출을 조절할 수 있는 형태이기에 안과 약물 전달 점안액의 대체재로 도입되었다. 이 논문에서는 polypropylene 몰드 안에서 새로운 가교제인 ethylaluminium diacrylate(EADA)와 methyl methacrylate(MMA), 2-hydroxyethyl methacrylate(HEMA), N-vinyl pyrrolidone(NVP)의 공중합을 통해 아크릴 하이드로젤 막을 제조하였다. 그리고 하이드로젤 막의 팽윤 거동과 기계적 물성을 조사하였다. 약물 방출 성능은 친수성약물 timolol maleate와 사이크로덱스트린으로 포접한 소수성 약물인 α-tocopherol로 평가하였다. 또한 비교를 위하여 기존의 가교제인 ethylene glycol dimethacrylate(EGDMA)를 사용한 하이드로젤을 제조하였다. 실험결과 EADA 가교제로 제조한 하이드로젤 막의 인장강도(0.168 MPa)는 EGDMA로 제조한 하이드로젤 막의 인장강도(0.136 MPa)보다 훨씬 향상되었다. 0.1mol% EADA로 가교시켜 만든 하이드로젤 막은 30시간 후 66%의 α-tocopherol 약물방출을 나타낸 반면 0.1 mol% EGDMA로 가교시켜 만든 하이드로젤 막은 동일한 시간 동안에 42%의 약물방출을 나타내었다. 한편, 2일간의 섬유아세포 배양실험에서 EADA를 함유하는 하이드로젤 막은 EGDMA를 함유하는 하이드로젤 막보다 훨씬 우수한 생리활성을 나타내었다.

Keywords: hydrogel membrane; cross-linker; ethylaluminium diacrylate; cyclodextrin

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2016; 40(4): 628-634

    Published online Jul 25, 2016

  • 10.7317/pk.2016.40.4.628
  • Received on Feb 18, 2016
  • Accepted on Mar 31, 2016