Article
  • Biological Safety Evaluation of Polyketones as Biomaterials
  • Lee MH, Lee DH, Baek HS, Kwon BJ, Koo MA, Kim MS, Seon GM, Park JC
  • 생체재료로서 적용을 위한 폴리케톤의 생물학적 안전성 평가
  • 이미희, 이대형, 백현숙, 권병주, 구민아, 김민성, 선경미, 박종철
Abstract
Biomaterials for clinical applications such as medical and implant devices require evaluation to determine their biocompatibility. This study aimed to evaluate the initial biological safety of polyketone (PK) polymers, which have potential use as biomaterials. It presents results from cytotoxicity and genotoxicity assays and tests determining the levels of skin irritation, sensitization, and acute systemic toxicity caused by PK. The PK polymers showed no cytotoxicity, genotoxicity, allergenicity, irritancy, and systemic toxicity. These results indicate that the PK polymers are potentially biological safe and could be used to replace non-degradable polymeric biomaterials.

생체재료는 의료기기로서 임상에 적용되기 위해서는 생물학적 안전성 평가에 의한 생체적합성 확보가 필수적이다. 이번 연구에서는 폴리케톤 고분자의 생체재료로서 사용 가능성을 평가하기 위해 생물학적 안전성 평가를 실시하였다. 폴리케톤 고분자의 용출물로 고분자의 생체적합성을 판단하는 생물학적 안전성 초기실험인 세포독성, 유전독성, 피부자극성, 감작성, 전신독성 시험을 실행하였다. 모든 시험에서 폴리케톤 고분자는 독성을 유발하지 않음을 확인할 수 있었으며, 이러한 결과는 폴리케톤 고분자가 생체재료로서 생물학적 안전성이 있으며 비분해성 고분자를 대체할 수 있을 것으로 판단된다.

Keywords: polyketones; biomaterials; biocompatibility; biological safety

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2016; 40(2): 225-231

    Published online Mar 25, 2016

  • 10.7317/pk.2016.40.2.225
  • Received on Sep 25, 2015
  • Accepted on Nov 10, 2015