Article
  • Characterization and Effect of Inflammatory Reaction of Duck-Feet Derived Collagen/PLGA(Poly lactic-co-glycolide) Hybrid Scaffold
  • Kim SM, Kim HM, Kuk H, Kim EY, Song JE, Suh DS, Park CH, Khang G
  • 오리발 유래 콜라겐/락타이드 글리콜라이드 하이브리드 지지체의 특성 및 염증 완화 효과
  • 김수민, 김혜민, 국 현, 김은영, 송정은, 서동삼, 박찬흠, 강길선
Abstract
In this study, hybrid scaffold composed of duck's feet extract (DC)/poly(lactic-co-glycolide) (PLGA) were fabricated to apply in tissue engineering. Characterizations such as compressive strength, SEM analysis and MTT were performed for the analysis of basic properties. RT-PCR, ROS and H&E staining were carried out for anti-inflammatory effect. DC/PLGA scaffolds have shown excellent mechanical properties and proliferation and can reduce inflammatory response. This study suggested that DC/PLGA scaffolds may serve as a potential cell delivery vehicle and a structural basis for tissue engineering.

본 연구에서는 오리발에서 추출한 콜라겐(extracted from feet of ducks)을 함유한 poly(lactic-co-glycolide) (PLGA) 복합 지지체를 제조하여 조직 공학적으로 적용될 수 있도록 지지체의 기본 특성과 염증 반응을 알아보고자 하였다. 그 특성을 알아보기 위하여 압축강도, SEM, MTT를 측정하였으며, RT-PCR, ROS 그리고 조직화학적 염색을 통해 염증반응을 확인하였다. 그 결과 DC/PLGA 지지체는 기계적 성질 및 증식이 우수하고 염증반응 또한 완화시켜 줄 수 있음을 알 수 있었다. 이로써, DC가 첨가된 PLGA 지지체가 조직공학적인 지지체로 적용될 가능성을 확인하였다.

Keywords: collagen; feet of duck; inflammatory reaction; scaffold; tissue engineering

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2015; 39(6): 837-845

    Published online Nov 25, 2015

  • 10.7317/pk.2015.39.6.837
  • Received on Feb 13, 2015
  • Accepted on Apr 28, 2015