Article
  • Fabrication of Microparticles with Anisotropic Patchy Based on Sequential Micromolding Technique
  • Lee B, Choi CH, Kim J, Kang SM, Nam JO, Jin SH, Lee CS
  • 순차적 마이크로 몰딩 방법을 이용한 이방성 패치 입자 제조 기술
  • 이병진, 최창형, 김종민, 강성민, 남진오, 진시형, 이창수
Abstract
This study reports a simple sequential micromolding method to produce monodisperse anisotropic microparticles with precisely controllable patchy size and chemistry of compartmentalization. Specifically, our fabrication procedure involves sequential formation of primary and secondary compartments in micromolds via surface tension-induced droplet formation coupled with simple photopolymerization. We demonstrate the capability of sequential micromolding technique by generating Mickey mouse-shaped particles with precisely controllable patchy size and chemistry of compartment and the fabrication method needs no sophisticated control or expensive facilities. The micromolding technique applied in this study can control the size of patchy diameter from 15 to 31 μm by simply adjusting the concentration of photocurable monomer in ethanol. Finally, the Mickey mouse-shaped microparticles with negatively charged patches are confirmed by selective binding of positively charged fluorescence dyes. These results prove a simple, robust, and scalable fabrication of highly monodisperse and complex anisotropic microparticles in a controlled manner based on sequential micromolding.

본 연구는 이방성 패치를 가지는 마이크로 입자의 제조를 위한 순차적 마이크로 몰딩 기술에 관한 것이다. 희석된 단량체와 젖음성 유체를 사용하여 PDMS 마이크로 몰드 상에서 1차적으로 구형의 입자를 제조하고, 물리적, 화학적 이방성을 가지는 입자를 간편하게 제조하는 기술이다. 본 연구팀은 실제 미키마우스 형태의 입자를 제조하여 제시한 방법이 실제로 구현 가능함을 입증하였고, 또한 휘발성 용매를 이용하여 단량체의 농도를 조절함으로써 미키마우스 형태 입자에서 패치의 크기를 15에서 31 μm까지 제어할 수 있었다. 더 나아가, 물리적, 화학적 특성 이방성을 동시에 가지는 정전기적 이방성 입자를 제조하였고, 수용액 상에서 전하를 가지는 형광염료를 통해 선택적인 염색을 하고 이를 형광 분석을 통해 입증하였다. 본 연구에서 제시한 마이크로 몰딩 기술은 간단한 방법으로 이방성 입자를 제조하는 것이 가능하며 이러한 방법은 자기조립 구조체를 제조하는 방법에 널리 이용이 가능할 것으로 판단한다.

Keywords: anisoptropy; patchy; microparticle; micromolding; Mickey mouse

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2015; 39(5): 814-819

    Published online Sep 25, 2015

  • 10.7317/pk.2015.39.5.814
  • Received on Mar 18, 2015
  • Accepted on Apr 25, 2015