Article
  • Improved Dissolution Behavior of Aceclofenac Loadings with Kollidon VA 64 Using Spray Drying and Rotary Evaporation Process
  • Yang J, Park JY, Lee CJ, Kim HM, Lee HG, Jang NG, Ko HA, Cho SA, Yang DH, Khang G
  • 분무건조와 용매증발을 이용한 Kollidon VA 64에 포접된 아세클로페낙의 개선된 용출 거동
  • 양재원, 박진영, 이천중, 김혜민, 이현구, 장나금, 고현아, 조선아, 양대혁, 강길선
Abstract
In order to improve the poor water solubility of aceclofenac, it was loaded into solid Kollidon VA 64 dispersion prepared by spray drying and rotary evaporation methods using different drug and polymer ratios. Morphology and physicochemical behavior of the aceclofenac loaded solid dispersions was analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and differential scanning calorimetry (DSC). Encapsulation efficiency and dissolution behavior in a simulated intestinal juice of aceclofenac in the solid dispersions was measured using HPLC and the latter was compared with that of the active pharmaceutical ingredient (API) and Airtal®. It was demonstrated that two methods could significantly improve the dissolution behavior of aceclofenac.

난용성 약물인 아세클로페낙의 용해도를 개선하기 위해 약물과 고분자의 다른 비율을 사용하여 분무건조와 용매증발의 방법으로 Kollidon VA 64의 고체분산체를 제조하였다. 아세클로페낙을 포접하는 고체분산체의 형태학적, 물리화학적 분석을 하기 위해, 전자주사현미경(SEM), 푸리에변환 적외선분광법 (FTIR), 시차주사 열량측정법 (DSC) 등이 사용되었다. 포접률과 인공장액에서의 용출 거동은 HPLC를 사용하여 측정하였고, 비교를 위해 원약물과 시판제 Airtal®이 사용되었다. 이것은 두 가지 방법에 따라 개선된 용출 거동을 나타내었다.

Keywords: aceclofenac; dissolution rate; rotary evaporation; solid dispersion; spray drying.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2015; 39(1): 6-12

    Published online Jan 25, 2015

  • Received on Feb 6, 2014
  • Accepted on Jul 12, 2014