Article
  • Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing
  • Panichpakdee J, Pavasant P, Supaphol P
  • Asiaticoside/2-Hydroxypropyl-β-cyclodextrin 포접화합물 함유 셀룰로오스 아세테이트 섬유 매트의 전기방사: 창상피복제로서 사용가능성과 방출특성
  • Panichpakdee J, Pavasant P, Supaphol P
Abstract
Cellulose acetate (CA) fiber mats containing inclusion complexes of asiaticoside (AC) in 2-hydroxypropyl-β-cyclodextrin (HPβCD) for potential usage as wound dressings were developed. The AC/HPβCD complex-loaded CA fibers at various HPβCD to AC molar ratios of 0.5, 1, and 2 were prepared in 90:10 v/v mixture of 80% (v/v) acetic acid and N,N-dimethylacetamide (DMAc) via electrospinning. The maximum released amounts of AC depended on the HPβCD content and were much greater than those released from the AC-loaded CA fiber mat. In the in vitro study, indirect cytotoxic evaluation with human dermal fibroblasts (HDFa) showed that these materials released no substances in the levels that were harmful to the cells and the cells appeared to attach and proliferate well on these substrates. However, only the CA fiber mats containing AC/HPβCD complexes at the HPβCD to AC molar ratio of 0.5 was effective in upregulating the production of collagen of the cultured cells.

Keywords: asiaticoside; 2-hydroxypropyl-β-cyclodextrin; cellulose acetate; wound dressings; electrospinning.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
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This Article

  • 2014; 38(3): 338-350

    Published online May 25, 2014

  • Received on Nov 12, 2013
  • Accepted on Feb 12, 2014