Article
  • Synthesis of Dendrimer with PEG Core by Click Chemistry
  • Han SC, Jin SH, Lee JW
  • 클릭 화학에 의한 PEG 핵을 갖는 덴드리머의 합성
  • 한승철, 진성호, 이재욱
Abstract
Efficient stitching methods for the synthesis of Frechet-type dendrimers with linear PEG units at a core were elaborated. The synthetic strategy involved an inexpensive 1,3-dipolar cycloaddition reaction between an alkyne and an azide in the presence of Cu(I) species which is known as the best example of click chemistry. The linear core building blocks, two diazido-PEG units, were chosen to serve as the azide functionalities for dendrimer growth via click reactions with the alkyne-dendrons. These two building blocks were employed together with the alkyne-functionalized Frechet-type dendrons in a convergent strategy to synthesize two kinds of Frechet-type dendrimers with different linear core units.

선형 PEG단위를 덴드리머의 중심에 갖는 덴드리머의 합성을 위한 효율적인 연결 방법이 개발되었다. 합성 전략은 알카인과 아자이드기 사이의 반응을 구리(1)촉매의 존재하에서 진행하는 클릭화학을 이용하였다. 덴드리머의 핵으로 작용할 수 있는 단위체인 옥타(에틸렌글리콜)디아자이드와 도데카(에틸렌글리콜)디아자이드를 합성하였고, 이 두 화합물의 아자이드기는 덴드리머의 형성에 이용되었다. 두 디아자이드화합물을 알카인 덴드론과 클릭 반응을 통해서 덴드리머의 핵의 선형 길이가 다른 두 종류의 덴드리머 제조에 대한 수렴형 합성법을 완성하였다.

Keywords: alkyne; azide; click chemistry; dendrimers.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2012; 36(3): 295-301

    Published online May 25, 2012

  • Received on Aug 28, 2011
  • Accepted on Nov 12, 2011