Article
  • Blood Compatibility of Sulfonated Poly(ethylene oxide)-grafted Polyurethane/Polystyrene IPN(Ⅱ): Surface Properties and in vitro Platelet Adhesion Test
  • Yoon YS, Kim SC
  • 술폰화된 폴리에틸렌옥사이드가 그라프트된 폴리우렌탄/폴리스티렌 IPN의 혈액적합성에 관한 연구 (II) : 표면 특성 및 혈소판 점착 실험
  • 윤여상, 김성철
Abstract
Our research group has investigated the blood compatibility of PU/PS IPN with hydrophilic-hydrophobic microphase separated structure and P대-grafted PU/PS IPN. In this study, the effect of incorporation of ions into PU/PS IPN on blood compatibility was investigated. Ionization was accomplished by quaternizing the tertiary amine of N-MDEA in PU with γ-propane sultone. The fractured surface and surface of PU/PS IPNs all exhibited fonated PU/PS IPNs with ionic sulfonate group were more hydrophilic than the corresponding nonionized materials. In the blood compatibility test, the amount of platelets adsorbed, activated upon the PU/PS IPNs were reduced compared with PU and PS. Sulfonated PU/PS IPNs with ionic sulfonate group showed enhanced blood compatibility compared with the corresponding nonionized PU/PS IPNs due to synergistic effect of microphase separated structure, mobility of PEO side chains and negatively charged sulfonate groups.

친수성/소수성 미세상분리 구조를 갖는 PU/PS IPN은 혈액 적합성을 갖는다. 이러한 PU/PS IPN이 PU부분의 3급 아민 N-MDEA를 γ-propane sultone과 반응시켜 4급화 하여 술폰 이온을 도입한 술폰화PU/PS IPN과 술폰화 P대-grafted PU/PS IPN을 합성하여 재료의 표면 특성과 혈액 적합성을 혈소판 점착 실험을 통해 알아 보았다. 모든 PU/PS IPN은 친수성 PU연속상에 소수성 PS가 분산된 미세상분리 구조를 나타냈다. 술폰 이온과 친수성 P대 사슬의 영향으로 술포화 PEO-grafted PU/PS IPN은 친수성이 상당히 증가하고 물과의 계면 에너지도 감소하였다. 또한 혈소판 점착 실험 결과 PU/PS IPN은 친수성/소수성 미세상분리 구조에 의해 혈소판의 활소수성 미세상분리 구조, 음이온 술폰산기와 유동성 PEO 사슬의 상승작용에 의해 매우 향상된 혈액 적합성을 나타냈다.

Keywords: IPN(interpenetrating polymer newirjd); blood compatibility; phase separated structure; sulfonated PEO

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1999; 23(6): 926-935

    Published online Nov 25, 1999