Article
  • Transdermal Therapeutic System of Narcotic Analgesics Using Nonporous Membrane(I): Effect of the Ethanol Permeability on Vinyacetate Content of EVA Membrane
  • Kwon H, Khang G, Song HY, Lee HB
  • 바다공성 막을 이용한 마취제의 경피투여 치료 시스템(I) : Vinylacetate 함량에 따른 EVA 막의 에탄올 투과 효과
  • 권현, 강길선, 송해영, 이해방
Abstract
The fundamental properties of transdermal therapeutic patch as narcotic analgesics agent has been investigated. From the study of drug and ethanol release patterns from the fentanyl base(FB) patches through diffusion cell and hairless mouse skin, it was observed that the FB release patterns were largely affected by the content of vinyl acetate (VA) of ethylene-co-vinyl acetate(EVA) membrane, and volume fraction of ethanolic solution. Additionally, a variety of control mombrane as a function of VA content were examined for swelling following equilibration with ethanolic solutions. Generally, ethanol was incorporated into a transdermal therapeutic device to enable the controlled delivery of enhancer and drug to the skin surface. In vitro skin permeation analysis of the control mombrane showed that ethanol flux was lineraly related to the ethanol volume fraction. This result was shown that drug permeability increased with increasing as the content of VA. But, the FB flux from saturated aqueous ethanol solutions increases until 80% ethanol volume fraction. Over 80% ethanol volume fraction, the FB flux through skin samples is independent of ethanol volume. These results showed that the decrease in skin permeation due to dehydration is the dominant effect.

현재 마취제로 많이 사용되는 fentanyl base (FB)을 이용한 경피투여용 패취의 기본 물성을 알아보았다. 확산 셀과 hairless mouse 피부를 이용하여 제조된 FB 패취로부터 약물과 에탄올의 방출특성을 조사한 결과 ethylene-co-vinyl acetate (EVA)막의 vinyl acetate(VA)함량, gelling agent의 에탄올 함량에 영향을 받는 것으로 나타났다. 또한 에탄올 용액 하에서 VA 함량에 따른 조절막의 평형 팽윤특성을 조찰하여 보았다. 일반적으로 에탄올은 경피 치료 장치내에서 피부표면에 약과 enhancer의 전달 속도를 조절할 수 있다. In vitro 상태에서 조절막의 피부 투과 분석은 에탄올 flux가 에탄올 부피에 직접적으로 영향을 받음을 보여준다. 이러한 결과로 약물의 투과도는 VA 함량이 증가할수록 증가함을 보여준다. 그러나 수화된 에탄올 용액에서의 FV flux는 에탄올 부피비 80%까지 증가하나 80%를 넘어서는 피부를 통한 FB flux는 에탄올 부피에 영향을 받지 않는다. 이러한 결과는 dehydration에 기인한 피부 투과의 감소가 주된 효과임을 보여준다.

Keywords: fentanyl base; EVA membrane; ethanol; permeability; transdermal therapeutic device

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1999; 23(3): 421-426

    Published online May 25, 1999