Article
  • Preparation of Stimuli-Responsive Polymeric Membranes and Their Permeation Characteristics of Drugs : Ⅳ. Functionalization of Polyamide Membranes Prepared by UV Irradiation Method and Their Riboflavin Permeation
  • Ihm SY, Shim JK, Lee YM, Kang DM, Cho CS, Park YH
  • 자극감응성 고분자막의 제조와 약물투과특성 :Ⅳ. UV조사법에 의한 폴리아미드막의 기능화와 리보플라빈의 투과특성
  • 임성윤, 심진기, 이영무, 강덕만, 조종수, 박영훈
Abstract
Acrylic acid, methacrylic acid and N-isopropylacrylamide(NIPAm) were grafted onto the porous polyamide membrane using ultraviolet irradiation method. The riboflavin permeation behaviors through the prepared graft membranes were investigated as a function of the change in pH, temperature and the graft density. Acrylic aicd graft membrane showed a rapid decrease in permeability at pH range between 4 and 5, while methacrylic acid graft membrane showed the pH sensitivity in pH 6∼7. The largest ratio of permeability at pH 7 and 4 is about 1.3 for UA-1 and UM-1 membranes. As NIPAm is grafted onto the polyamide membrane, the permeability increased rapidly at 31 ∼33℃ due to the lower critical solution temperature(LCST). As acrylamide is copolymerized with NIPAm, LCST increased to 40∼50℃. We also compared the permeabilities and the pH sensitivities of membranes prepared from the different initiation methods as reported earlier.

폴리아미드 다공성막표면에 자외선을 조사하여 아크릴산과 메타크릴산 _그리고 N-isopropylacylamide(NIPAm)를 그라프트중합하여 pH와 온도변화 및 그라프트 밀도변화에 따른 리보플라빈의 투과도 변화를 고찰하였다. 아크릴산이 그라프트된 막은 pH 4∼5의 범위에서, 메타크릴산이 그라프트된 막은 pH 6∼7의 범위에서 급격한 투과도 감소를 나타내었다. pH 7과 pH 4에서의 투과도의 비는 큰 경우가 1.3 정도였다. NIPAm이 그라프트되면 lower critical solution temperature(LCST)로 인해 약 31∼33℃부근에서 급격한 투과도 증가가 나타났다. 아크릴아미드가 NIPAm과 공중합되면 LCST 전이온도가 40∼50℃로 높아졌다. 기능성 단량체들의 개시방법들에 따른 투과도 및 pH변화를 살펴보았다.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1994; 18(3): 406-411

    Published online May 25, 1994