Article
  • Formulation Design of pH Adjusted Rebamipide Solid Dispersions for Improved Solubility
  • Byungkwan Moon*,#, Youngjun Son**,#, Seung Jae Kim**, Sunjae Park**, Won Kyung Kim**, Jeong Eun Song**, and Gilson Khang*, **, ***,†

  • *Department of PolymerNano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    **Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • 용해도 개선을 위한 pH가 조절된 레바미피드 고체분산체의 제형 설계
  • 문병관*,# · 손영준**,# · 김승재** · 박선재** · 김원경** · 송정은** · 강길선*, **, ***,†

  • *전북대학교 고분자나노공학과, **전북대학교 바이오나노융합공학과, ***전북대학교 고분자융합소재연구소

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Kobayashi, M.; Takeuchi, M.; Hashimoto, S.; Mizuno, K. I.; Sato, Y.; Narisawa, R.; Aoyagi, Y. Contributing Factors to Gastric Ulcer Healing after Endoscopic Submucosal Dissection Including the Promoting Effect of Rebamipide. Dig. Dis. Sci. 2012, 57, 119-126.
  •  
  • 2. Jeon, J.; Kim, J. Risk of Post-Myocardial Infarction Pneumonia with Proton Pump Inhibitors, H2 Receptor Antagonists and Mucoprotective Agents: A Retrospective Nationwide Cohort Study. J. Pers. Med. 2022, 12, 78.
  •  
  • 3. Deshpande, A.; Pasupuleti, V.; Thota, P.; Pant, C.; Mapara, S.; Hassan, S.; Rolston, D. D. K.; Sferra, T. J.; Hernandez, A. V. Acid-suppressive Therapy is Associated with Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Meta-analysis. J. Gastroenterol. Hepatol. 2013, 28, 235-242.
  •  
  • 4. Rosenberg, K. Acid Suppressants Increase Risk of Colonization with Multidrug-Resistant Microorganisms. AJN Am. J. Nurs. 2020, 120, 57.
  •  
  • 5. Naito, Y.; Yoshikawa, T. Rebamipide : A Gastrointestinal Protective Drug with Pleiotropic Activities. Expert Rev. Gastroenterol. Hepatol. 2010, 4, 261-270.
  •  
  • 6. Arakawa, T.; Kobayashi, K.; Yoshikawa, T.; Tarnawski, A. Rebamipide : Overview of Its Mechanisms of Action and Efficacy in Mucosal Protection and Ulcer Healing. Dig. Dis. Sci. 1998, 43, 5-13.
  •  
  • 7. Zhang, S.; Qing, Q.; Bai, Y.; Mao, H.; Zhu, W.; Chen, Q.; Zhang, Y.; Chen, Y. Rebamipide Helps Defend Against Nonsteroidal Anti-inflammatory Drugs Induced Gastroenteropathy : A Systematic Review and Meta-analysis. Dig. Dis. Sci. 2013, 58, 1991-2000.
  •  
  • 8. Jaafar, M. H.; Safi, S. Z.; Tan, M. P.; Rampal, S.; Mahadeva, S. Efficacy of Rebamipide in Organic and Functional Dyspepsia : a Systematic Review and Metaanalysis. Dig. Dis. Sci. 2018, 63, 1250-1260.
  •  
  • 9. Markovic, M.; Zur, M.; Dahan, A.; Cvijić, S. Biopharmaceutical Characterization of Rebamipide : The Role of Mucus Binding in Regional-dependent Intestinal Permeability. Eur. J. Pharm. Sci. 2020, 152, 105440.
  •  
  • 10. Okawa, S.; Sumimoto, Y.; Masuda, K.; Ogawara, K. I.; Maruyama, M.; Higaki, K. Improvement of Lipid Solubility and Oral Bioavailability of a Poorly Water-and Poorly Lipid -soluble Drug, Rebamipide, by utilizing Its Counter Ion and SNEDDS Preparation. Eur. J. Pharm. Sci. 2021, 159, 105721.
  •  
  • 11. Kalepu, S.; Nekkanti, V. Insoluble Drug Delivery Strategies : Review of Recent Advances and Business Prospects. Acta Pharm. Sin. B. 2015, 5, 442-453.
  •  
  • 12. Zuccari, G.; Russo, E.; Villa, C.; Zorzoli, A.; Marimpietri, D.; Marchitto, L.; Alfei, S. Preparation and Characterization of Amorphous Solid Dispersions for the Solubilization of Fenretinide. Pharmaceuticals. 2023, 16, 388.
  •  
  • 13. Vo, C. L. N.; Park, C.; Lee, B. J. Current Trends and Future Perspectives of Solid Dispersions Containing Poorly Watersoluble Drugs. Eur. J. Pharm. Biopharm. 2013, 85, 799-813.
  •  
  • 14. Frizon, F.; de Oliveira Eloy, J.; Donaduzzi, C. M.; Mitsui, M. L.; Marchetti, J. M. Dissolution Rate Enhancement of Loratadine in Polyvinylpyrrolidone K-30 Solid Dispersions by Solvent Methods. Powder Technol. 2013, 235, 532-539.
  •  
  • 15. Tekade, A. R.; Yadav, J. N. Yadav. A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs. Adv. Pharm. Bull. 2020, 10, 359-369.
  •  
  • 16. Adibkia, K.; Barzegar-Jalali, M.; Maheri-Esfanjani, H.; Ghanbarzadeh, S.; Shokri, J.; Sabzevari, A.; Javadzadeh, Y. Physicochemical Characterization of Naproxen Solid Dispersions Prepared Via Spray Drying Technology. Powder Technol. 2013, 246, 448-455.
  •  
  • 17. Pradhan, R.; Tran, T. H.; Choi, J. Y.; Choi, I. S.; Choi, H. G.; Yong, C. S.; Kim, J. O. Development of A Rebamipide Solid Dispersion System with Improved Dissolution and Oral Bioavailability. Arch. Pharm. Res. 2015, 38, 522-533.
  •  
  • 18. Ha, E. S.; Lee, S. K.; Jeong, J. S.; Sim, W. Y.; Yang, J. I.; Kim, J. S.; Kim, M. S. Solvent Effect and Solubility Modeling of Rebamipide in Twelve Solvents at Different Temperatures. J. Mol. Liq. 2019, 288, 111041.
  •  
  • 19. Chaudhari, S. P.; Dugar, R. P. Application of Surfactants in Solid Dispersion Technology for Improving Solubility of Poorly Water Soluble Drugs. J. Drug Deliv. Sci. Technol. 2017, 41, 68-77.
  •  
  • 20. Tung, N. T.; Park, C. W.; Oh, T. O.; Kim, J. Y.; Ha, J. M.; Rhee, Y. S.; Park, E. S. Formulation of Solid Dispersion of Rebamipide Evaluated in a Rat Model for Improved Bioavailability and Efficacy. J. Pharm. Pharmacol. 2011, 63, 1539-1547.
  •  
  • 21. Tran, P. H. L.; Tran, T. T. D.; Lee, K. H.; Kim, D. J.; Lee, B. J. Dissolution-modulating Mechanism of pH Modifiers in Solid Dispersion Containing Weakly Acidic or Basic Drugs with Poor Water Solubility. Expert Opin. Drug Deliv. 2010, 7, 647-661.
  •  
  • 22. Qi, S.; Roser, S.; Edler, K. J.; Pigliacelli, C.; Rogerson, M.; Weuts, I.; Dycke, F. V.; Stokbroekx, S. Insights into the Role of Polymersurfactant Complexes in Drug Solubilisation / stabilisation During Drug Release from Solid Dispersions. Pharm. Res. 2013, 30, 290-302.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2024; 48(3): 299-304

    Published online May 25, 2024

  • 10.7317/pk.2024.48.3.299
  • Received on Nov 30, 2023
  • Revised on Feb 23, 2024
  • Accepted on Mar 11, 2024

Correspondence to

  • Gilson Khang
  • *Department of PolymerNano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    **Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • E-mail: gskhang@jbnu.ac.kr