Article
  • Biodegradable Polyurethane Scaffolds with Hard and Soft Compartments for Potential Bone-to-tendon Regeneration

  • Kangho Choi*, **,#, Young-Hyun Ryu*, **,#, Minju Song*, **,#, Soo Kyung Han*, **, Hana Lim***, Hyun-Jong Kim***, and Sung-Wook Choi*, **,†

  • *Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu,
    Bucheon-si, Gyeonggi-do 14662, Korea
    **Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Korea
    ***Surface Technology Group, Korea Institute of Industrial Technology (KITECH), Incheon 21999, Korea

  • 뼈-인대 재생을 위한 경질 및 연질 구획을 갖는 생분해성 폴리우레탄 지지체

  • 최강호*, **,# · 류영현*, **,# · 송민주*, **,# · 한수경*, ** · 임하나*** · 김현종*** · 최성욱*, **,†

  • *가톨릭대학교 바이오메디컬화학공학과, **가톨릭대학교 생명공학과, ***한국생산기술연구원 표면처리기술 연구그룹

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Loh, Q. L.; Choong, C. Three-dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size. Tissue Eng. Part B Rev. 2013, 19, 485-502.
  •  
  • 2. Ga, D.-H.; Lim, C.-M.; Jang, Y.; Son, T. I.; Han, D. K.; Joung, Y. K. Surface-modifying Effect of Zwitterionic Polyurethane Oligomers Complexed with Metal Ions on Blood Compatibility. Tissue Eng. Regen. Med. 2021.
  •  
  • 3. Choi, S. Y.; Li, M. X.; Kang, J. H.; Yang, D. H.; Joung, Y. K. Anti-thrombotic Polymer Surfaces Modified with Zwitterionic and Fluorinated Surface-migrating Oligomers. Surf. Interfaces 2021, 25, 101280.
  •  
  • 4. Casarrubios, L.; Gómez-Cerezo, N.; Sánchez-Salcedo, S.; Feito, M. J.; Serrano, M. C.; Saiz-Pardo, M.; Ortega, L.; de Pablo, D.; Díaz-Güemes, I.; Fernández-Tomé, B.; Enciso, S.; Sánchez-Margallo, F. M.; Portolés, M. T.; Arcos, D.; Vallet-Regí, M. Silicon Substituted Hydroxyapatite/VEGF Scaffolds Stimulate Bone Regeneration in Osteoporotic Sheep. Acta Biomater. 2020, 101, 544-553.
  •  
  • 5. Ghosh, M.; Halperin-Sternfeld, M.; Grigoriants, I.; Lee, J.; Nam, K. T.; Adler-Abramovich, L. Arginine-Presenting Peptide Hydrogels Decorated with Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration. Biomacromolecules 2017, 18, 3541-3550.
  •  
  • 6. Tits, A.; Ruffoni, D. Joining Soft Tissues to Bone: Insights from Modeling and Simulations. Bone Rep. 2021, 14, 100742.
  •  
  • 7. Lowen, J. M.; Leach, J. K. Functionally Graded Biomaterials for Use as Model Systems and Replacement Tissues. Adv. Funct. Mater. 2020, 30, 1909089.
  •  
  • 8. Spalazzi, J. P.; Boskey, A. L.; Pleshko, N.; Lu, H. H. Quantitative Mapping of Matrix Content and Distribution Across the Ligament-to-bone Insertion. PLoS ONE 2013, 8, e74349-e74349.
  •  
  • 9. Reddy, M. S.; Ponnamma, D.; Choudhary, R.; Sadasivuni, K. K. A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds. Polymers 2021, 13.
  •  
  • 10. Abe, M. M.; Martins, J. R.; Sanvezzo, P. B.; Macedo, J. V.; Branciforti, M. C.; Halley, P.; Botaro, V. R.; Brienzo, M. Advantages and Disadvantages of Bioplastics Production from Starch and Lignocellulosic Components. Polymers 2021, 13.
  •  
  • 11. George, A.; Sanjay, M. R.; Srisuk, R.; Parameswaranpillai, J.; Siengchin, S. A Comprehensive Review on Chemical Properties and Applications of Biopolymers and Their Composites. Int. J. Biol. Macromol. 2020, 154, 329-338.
  •  
  • 12. Li, X.; Xie, J.; Lipner, J.; Yuan, X.; Thomopoulos, S.; Xia, Y. Nanofiber Scaffolds with Gradations in Mineral Content for Mimicking the Tendon-to-bone Insertion Site. Nano Lett. 2009, 9, 2763-2768.
  •  
  • 13. Venkatesan, J.; Vinodhini, P. A.; Sudha, P. N.; Kim, S.-K. Chapter Five - Chitin and Chitosan Composites for Bone Tissue Regeneration. Adv. Food Nutr. Res. 2014, 73, 59-81.
  •  
  • 14. Ameer, J. M.; Pr, A. K.; Kasoju, N. Strategies to Tune Electrospun Scaffold Porosity for Effective Cell Response in Tissue Engineering. J. Funct. Biomater. 2019, 10, 30.
  •  
  • 15. Mooney, D. J.; Baldwin, D. F.; Suh, N. P.; Vacanti, J. P.; Langer, R. Novel Approach to Fabricate Porous Sponges of Poly(d,l-lactic-co-glycolic acid) without the Use of Organic Solvents. Biomaterials 1996, 17, 1417-1422.
  •  
  • 16. Sin, D.; Miao, X.; Liu, G.; Wei, F.; Chadwick, G.; Yan, C.; Friis, T. Polyurethane (PU) Scaffolds Prepared by Solvent Casting/Particulate Leaching (SCPL) Combined with Centrifugation. Mater. Sci. Eng.: C 2010, 30, 78-85.
  •  
  • 17. Lee, S. B.; Kim, Y. H.; Chong, M. S.; Hong, S. H.; Lee, Y. M. Study of Gelatin-containing Artificial Skin V: Fabrication of Gelatin Scaffolds Using a Salt-leaching Method. Biomaterials 2005, 26, 1961-1968.
  •  
  • 18. Wu, X.; Liu, Y.; Li, X.; Wen, P.; Zhang, Y.; Long, Y.; Wang, X.; Guo, Y.; Xing, F.; Gao, J. Preparation of Aligned Porous Gelatin Scaffolds by Unidirectional Freeze-drying Method. Acta Biomater. 2010, 6, 1167-1177.
  •  
  • 19. Ma, P. X.; Zhang, R. Microtubular Architecture of Biodegradable Polymer Scaffolds. J. Biomed. Mater. Res. 2001, 56, 469-477.
  •  
  • 20. Khorshidi, S.; Solouk, A.; Mirzadeh, H.; Mazinani, S.; Lagaron, J. M.; Sharifi, S.; Ramakrishna, S. A Review of Key Challenges of Electrospun Scaffolds for Tissue-engineering Applications. J. Regen. Med. Tissue Eng. 2016, 10, 715-738.
  •  
  • 21. Yan, R.; Jin, B.; Luo, Y.; Li, X. Optically Healable Polyurethanes with Tunable Mechanical Properties. Polym. Chem. 2019, 10, 2247-2255.
  •  
  • 22. Jang, J. Y.; Jhon, Y. K.; Cheong, I. W.; Kim, J. H. Effect of Process Variables on Molecular Weight and Mechanical Properties of Water-based Polyurethane Dispersion. Colloids Surf. A: Physicochem. Eng. Asp. 2002, 196, 135-143.
  •  
  • 23. Santamaria-Echart, A.; Arbelaiz, A.; Saralegi, A.; Fernández-d’Arlas, B.; Eceiza, A.; Corcuera, M. A. Relationship Between Reagents Molar Ratio and Dispersion Stability and Film Properties of Waterborne Polyurethanes. Colloids Surf. A: Physicochem. Eng. Asp. 2015, 482, 554-561.
  •  
  • 24. Athawale, V. D.; Kulkarni, M. A. Effect of Dicarboxylic Acids on the Performance Properties of Polyurethane Dispersions. J. Appl. Polym. Sci. 2010, 117, 572-580.
  •  
  • 25. García-Pacios, V.; Iwata, Y.; Colera, M.; Miguel Martín-Martínez, J. Influence of the Solids Content on the Properties of Waterborne Polyurethane Dispersions Obtained with Polycarbonate of Hexanediol. Int. J. Adhes. Adhes. 2011, 31, 787-794.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(2): 171-178

    Published online Mar 25, 2022

  • 10.7317/pk.2022.46.2.171
  • Received on Oct 20, 2021
  • Revised on Nov 23, 2021
  • Accepted on Dec 6, 2021

Correspondence to

  • Sung-Wook Choi

  • *Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu,
    Bucheon-si, Gyeonggi-do 14662, Korea
    **Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Korea

  • E-mail: choisw@catholic.ac.kr