Blood compatibility has been studied for copoly(urethane-g-γ-benzyl-L-glutamate) which was synthesized by ring opening anionic polymerization of N-carboxyanhydride of γ-benzyl-L-glutamate(γ-BLG NCA) with polyurethane. Polyurethane was dissolved in dehydrated dimethylformamide and added sodium hydride under nitrogen atmosphere at 0℃. After the hydrogens of urethane bonds were substituted by sodium, p-bromoaniline was added and then γ-benzyl-L-glutamate was graftcopolymerized on the amine substituted urethane bonos. In order to adjusts the grafted chain length the amount of γ-BLG NCA added was controlled. The microsphere column method was used for the evaluation of blood compatibility. Human blood was passed through the glass column packed with glass beads precoated with polymers and the behavior of platelet on the polymer surfaces was investigated by scanning electron microscope and average number of eluted platelets was also measured. The contact angle and the clotting time of samples were investigated in order to examine the thromboresistant property of copolymers.

폴리우레탄에 γ-benzyl-L-glutamate(γ-BLG)를 그라프트시켜 공중합체의 혈액적 합성을 검토하였다. 그라프트 공중합체는 음이온중합으로 합성하였다. 폴리우레탄을 dimethylformamide에 녹이고 0℃항온으로 유지시켜 질소기류하에서 sodium hydride를 넣어 우레탄결합의 수소를 나트륨으로 치환시킨 다음 다시 p-bromoaniline으로 치환하여 아민기를 도입한 후 이 아민기를 개시제로 γ-BLG를 그라프트공중합시켰다. 그라프트쇄의 길이는 γ-BLG N-carboxyanhydride양으로 조절하였다. 혈액적합성을 검토하기 위해 microsphere column법을 이용하였다. 합성한 공중합체를 코팅한 유리구슬을 충진시킨 코팅된 유리관에 혈액을 유출시켜 유리구슬표면에 코팅된 폴리머에 흡착된 혈소판의 모폴로지를 주사전자현미경으로 관찰하였으며 유출된 혈액으로부터 미흡착 혈소판의 수를 측정하였다. 또한 폴리머의 접촉각과 혈액응고시간을 측정하여 항혈전성을 검토하였다.

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