The applicability of chitin and chitosan for prolonged-release preparations of a water soluble drug was examined. In this study, the dissolution behavior of physical and ground mixtures of p-aminosalicylic acid(PAS), a water soluble drug, with chitin and chitosan was investigated. The intensity of powder X-ray diffraction pattern in a ground mixture (GM) was smaller than that of a physical mixture (PM), suggesting a relative decrease in the size of the crystals of PAS in the ground mixture. The dissolution rate of PAS from the ground mixtures was significantly slower than that from the physical mixtures or from pure PAS powder. Particularly, the ground mixture with chitosan showed the slowest dissolution. These results indicated that the 1:2 ground mixing ratio of PAS-chitosan mixture might be suitable and the results obtained at this ratio could be practically useful, because of the amount of excipient should be small for formulation.

수용성 약물의 방출 지연성에 대하여 키틴과 키토산의 적용성을 검토하였다. 본 연구에서는 수용성 약물인 p-aminosalicylic acid (PAS)와 키틴, 키토산의 용해거동에 대하여 연구하였다. X-ray 회절에서 본 PAS 결정의 회절세기는 ground mixture 가 physical mixture 보다 적었다. 결정 크기가 작기 때문에 용출 속도는 ground mixture가 physical mixture나 순수한 PAS 분말보다는 훨씬 느렸으며, 특히 chitosan 에 ground mixture한 것이 가장 느렸다. 실제로 약물에 부형제를 적게 넣는 점을 고려한다면. PAS-chitosan(1:2) ground 혼합물이 실제적으로 약물에 사용할 수 있음을 지적해 준다.

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