PVA/CNC/BaSO₄ scaffolds for tissue regeneration were manufactured via a freeze-drying method. The BaSO₄ was mixed to make radiopaque scaffolds. The effect of BaSO₄ on the compressive strength and radiopacity was investigated. The CNC was added to increase a compressive stress of the scaffolds. The presence of BaSO₄ in PVA/CNC/BaSO₄ scaffold was revealed by a wide angle X-ray scattering and SEM-EDX. Compressive strength of the scaffold increased by approximately 20% with the help of CNC and little change with respect to BaSO₄ content was observed. Radiopacity was achieved by adding BaSO₄ of 5 wt%, revealed by X-ray imaging. MTT assay test confirmed the biocompatibility of PVA/CNC/BaSO₄ scaffolds.

PVA/CNC/BaSO₄ 조직 재생용 지지체를 동결건조법을 통해 제조하였으며, CNC 첨가로 인한 강도 향상 연구 및 BaSO₄ 첨가로 인한 방사선불투과성을 가져 조직 내 이식시 재료의 식별성 향상 연구를 진행한 결과, CNC 첨가로 인한 지지체의 강도는 약 20% 가량 높아졌으며, X-ray 촬영을 통해 BaSO₄ 5 wt% 첨가시 방사선불투과성을 가져 지지체의 뚜렷한 식별이 가능하였다. 또한, MTT 측정 결과, 실험기간동안 지지체의 세포 독성은 없는 것을 통해 생체적합성을 가지는 것을 확인하였다.

Keywords: polyvinyl alcohol, cellulose-nanocrystal, barium sulfate, scaffold, compressive strength, radiopacity.