To evaluate the physical properties and antioxidant duration of contact lenses by room temperature polymerization of hydrogel contact lenses containing lutein, a natural antioxidant, and layer by layer (LBL) coating with seaweed polysaccharide. A contact lenses containing lutein was coated with alginate and carrageenan. Drug release was calculated by measuring absorbance. To evaluate the physical properties of contact lenses, water content, contact angle, and oxygen permeability were measured, and surface analysis was conducted. LBL coating with seaweed polysaccharide on contact lenses containing lutein improved water contents, wettability, and oxygen transmissilility. It was found that the antioxidant duration increased as the LBL layer by seaweed polysaccharide was formed, and the duration increased further as the metal ion was added. It was confirmed that the antioxdant duration and physical properties were improved by forming the LBL coating layer with seaweed polysaccharide containing lutein.

천연 항산화제인 루테인이 포함된 하이드로젤 콘택트렌즈를 상온중합으로 제작하고, 해조다당류로 다층코팅층을 만들어서 콘택트렌즈의 물리적 특성 및 항산화 지속시간을 평가하고자 한다. 루테인이 포함된 하이드로젤 콘택트렌즈에 알지네이트와 카라기난으로 표면코팅하였다. 약물 방출농도는 흡광도로 측정하였으며 콘택트렌즈의 물리적 특성 평가와 표면 분석을 진행하였다. 루테인이 포함된 콘택트렌즈에 해조다당류로 코팅함으로써 함수율, 습윤성, 그리고 산소전달률이 향상되었다. 항산화 지속시간은 해조다당류에 의한 layer by layer(LBL)층이 형성될수록 증가하였으며 금속이온을 첨가할수록 더욱 증가하였다. 루테인이 포함되고 해조다당류로 LBL 코팅층을 형성함으로써 항산화 지속시간과 물리적 특성이 향상되는 것을 확인하였다.

Keywords: contact lenses, lutein, antioxidant, alginate, carrageenan.