Article
  • Drug Release Properties of Montelukast Imprinted Starch-based Biomaterials Adding Melanin as Photo-stabilizing Agent

  • Kyeong-Jung Kim# , Ji Yoon Kim*,# , Wang-Geun Shim**,† , and Soon-Do Yoon†

  • Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu, Jeollanam-do 59626, Korea
    *Korea basic science institute gwangju center, Gwangju, 61186, Korea
    **Department of Chemical Engineering, Sunchon National University, Suncheon, Jeollanam-do 57922, Korea

  • 광안정제로 멜라닌이 첨가된 Montelukast 각인 전분 기반 바이오 소재의 약물 방출 특성

  • 김경중# · 김지윤*,# · 심왕근**,† · 윤순도†

  • 전남대학교 화공생명공학과, *한국기초과학지원연구원 광주센터, **순천대학교 화학공학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

In this study, montelukast (MTL) imprinted starch-based biomaterials using mungbean starch (MS), polyvinyl alcohol (PVA), melanin (MEL) as a light stabilizer, and plasticizers were synthesized by the casting method and heat curing process. MTL release properties were evaluated at different temperatures and pH 5.5. Biomaterials were characterized using FE-SEM and FTIR. In addition, physical properties such as mechanical and water resistance properties for biomaterials were investigated. Results of MTL release properties in the buffer solution indicated that MTL was released about 36.74% within 120 min. In addition, MTL release from MEL-added biomaterials was increased about 1.30-1.43 times by the light stabilizer. In case of MTL release using the artificial skin, MTL was released continuously for 12 h, and the MTL release from MEL-added biomaterials was increased by about 1.54 times. MTL release in buffer solution followed the pseudo-Fickian diffusion mechanism, whereas the MTL release in artificial skin followed the non-Fickian diffusion mechanism.


본 연구에서는 montelukast(MTL), mungbean starch(MS), polyvinyl alcohol(PVA)과 광안정제로 melanin(MEL), 가소제들을 이용하여 MTL 각인 전분 기반 바이오 소재를 casting 방법과 열경화 공정을 이용하여 제조하고, pH 5.5에서 온도 변화에 따른 MTL 방출 특성을 평가하였다. 바이오 소재의 특성은 FE-SEM과 FTIR으로 분석하였다. 바이오 소재에 대한 기계적 특성, 내수성 같은 물리적 특성을 역시 조사하였다. 완충 용액에서 MTL은 120분 동안 약 36.74% 방출되었으며, MEL이 첨가된 바이오 소재는 MTL 방출이 1.30-1.43배 증가하였다. 인공피부에서 MTL은 12시간 동안 지속적으로 방출되었으며 MEL이 첨가된 경우 MTL의 방출량이 약 1.54배 증가하였다. 완충 용액에서 MTL의 방출 거동은 pseudo-Fickian 메커니즘을 따랐고, 반면에 인공피부에서 MTL의 방출 거동은 non-Fickian 메커니즘을 따랐다.


Keywords: starch-based biomaterials, montelukast, melanin, drug release mechanism, transdermal drug delivery system.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2024; 48(1): 10-19

    Published online Jan 25, 2024

  • 10.7317/pk.2024.48.1.10
  • Received on Jul 12, 2023
  • Revised on Aug 7, 2023
  • Accepted on Oct 20, 2023

Correspondence to

  • Wang-Geun Shim** , and Soon-Do Yoon

  • Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu, Jeollanam-do 59626, Korea
    **Department of Chemical Engineering, Sunchon National University, Suncheon, Jeollanam-do 57922, Korea

  • E-mail: wgshim@sunchon.ac.kr, yunsd03@chonnam.ac.kr