Article
  • In Situ Photo-crosslinkable Biodegradable Tissue Adhesive for Wound Healing

  • Hyeseon Lee# , Keum-Yong Seong# , Sodam Kim, Ajeesh Chandrasekharan,
    Dae Youn Hwang, Young Ki Hahn*, **, Moon-Chang Baek**, ***, Jun Lee****,† , and
    Seung Yun Yang†

  • Department of Biomaterials Science (BK21 Four Program), College of Natural Resources & Life Science, Pusan National University, Miryang 50463, Korea
    *Department of Biomedical Convergence Science and Technology, School of Convergence,
    Kyungpook National University, Daegu 41566, Korea
    **Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41566, Korea
    ***Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41566, Korea
    ****Department of Oral and Maxillofacial Surgery, School of Dentistry, College of Dentistry,
    Wonkwang University, Iksan 54538, Korea

  • 창상 치유를 위한 생체고분자 기반 광가교형 조직접착제 개발

  • 이혜선# · 성금용# · 김소담 · 아지시찬드라세카란 · 황대연 · 한영기*, ** · 백문창**, *** · 이 준****,† · 양승윤†

  • 부산대학교 생명자원과학대학 바이오소재과학과, *경북대학교 융합학부 의생명융합공학과, **경북대학교 의과대학 세포·기질연구소,***경북대학교 의과대학 분자의학교실,****원광대학교 치과대학 구강악안면외과학교실

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

Tissue adhesives are widely used in various medical fields for tissue bonding and wound closure. Existing glue-type tissue adhesives have disadvantages such as low biocompatibility or a long reaction time to achieve firm tissue adhesion. Herein we developed photocurable tissue adhesives by introducing photocrosslinkable methacrylate (MA) groups into biodegradable hyaluronic acid (HA) that enables strong tissue adhesion and wound sealing. The photocurable tissue adhesive formed a stable hydrogel layer with good tissue adhesion following short UV exposure (<5 s). By controlling the substitution rate of MA and polymer concentration, the mechanical properties and adhesion strength of the tissue adhesive could be easily manipulated. From the incisional wound animal model, the HA-based tissue adhesive used in this study showed better tissue adhesion and faster wound healing efficacy compared to commercial glues. Considering the high biocompatibility and biodegradability of HA, this photocurable adhesive would be useful in wound healing of various soft tissues.


조직접착제는 조직의 결합 및 상처 봉합의 목적으로 다양한 의료 분야에서 사용되고 있다. 기존의 액상 조직접착제는 생체적합성이 낮거나 우수한 접착력을 달성하기 위해 반응 시간이 오래 걸린다는 단점이 있다. 본 연구에서는 생분해성을 가진 히알루론산(hyaluronic acid, HA)에 광가교성 메타크릴레이트(methacrylate, MA) 그룹을 도입하여, 빛에 의해 빠르게 경화되어 상처 부위를 즉각적으로 봉합할 수 있는 광가교형 조직접착제를 개발하였다. 광경화형 조직접착제는 5초 이내의 짧은 UV 조사 후 조직에 높은 접착력을 보이면서 안정적인 하이드로젤 층을 형성하였다. MA의 치환도 및 고분자의 농도를 변화시켜, 접착제의 기계적 물성과 조직접착력도 손쉽게 조절할 수 있었다. 창상 동물모델 실험에서 HA 기반 조직접착제는 기존 상용 접착제에 비해 우수한 조직접착력 및 빠른 상처 회복을 보였다. HA의 높은 생체적합성과 생분해성을 고려할 때, HA 기반 광가교형 조직접착제는 다양한 연조직의 상처 치료에 활용도가 높을 것으로 예상된다.


Keywords: photo-crosslinking, hyaluronic acid, wound healing, tissue adhesive.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(2): 216-222

    Published online Mar 25, 2022

  • 10.7317/pk.2022.46.2.216
  • Received on Nov 11, 2021
  • Revised on Dec 30, 2021
  • Accepted on Jan 5, 2022

Correspondence to

  • Jun Lee**** , and Seung Yun Yang

  • Department of Biomaterials Science (BK21 Four Program), College of Natural Resources & Life Science, Pusan National University, Miryang 50463, Korea
    ****Department of Oral and Maxillofacial Surgery, School of Dentistry, College of Dentistry,
    Wonkwang University, Iksan 54538, Korea

  • E-mail: omslee@wku.ac.kr, syang@pusan.ac.kr