Article
  • Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters
  • Rukiye Sevinç Özakar  and Emrah Özakar

  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

  • 품질관리 향상을 위한 다양한 생체고분자의 영향과 동결건조 부유약제의 특성 분석
  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

Conventional oral drug systems are unable to keep drug concentration within the therapeutic range, and administration of the dosage form several times a day can cause significant fluctuations in plasma drug concentration. Therefore, floating drug delivery systems are being developed. In this study, floating tablets with a model drug (ampicillin sodium-Amp.Na) were successfully prepared using different polymers by the lyophilization technique. This study aims to prepare and characterize floating lyophilized tablets to understand the effect of different biopolymers on quality control parameters more clearly. Within the scope of characterization studies, many parameters were evaluated successfully. All tablets showed 24-hour release and had a mesoporous structure, as understood from the Brunauer-Emmett-Teller (BET) analysis. It has been determined from the Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses that Amp.Na doesn’t interact with excipients and is an amorphous form. These formulations can be used for other drugs in the future, and optimum properties can be easily characterized.


Keywords: floating tablet, lyophilization, polymers, release kinetics, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2020 Impact Factor : 0.493
  • Indexed in SCIE

This Article

  • 2022; 46(2): 145-158

    Published online Mar 25, 2022

  • 10.7317/pk.2022.46.2.145
  • Received on Oct 5, 2021
  • Revised on Nov 24, 2021
  • Accepted on Dec 19, 2021

Correspondence to

  • Rukiye Sevinç Özakar, and Emrah Özakar
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

  • E-mail: emrahozakar@atauni.edu.tr