2-Hydroxyalkyl methacrylate polymer have been considered as biomaterial for medical applications. These polymers swell in water to become soft hydrogels. The hydrogels are widely used in the preparation of burn dressing, soft contact lens and artificial membranes. The radical copolymerization of 2-hydroxyethyl methacrylate (HEMA) and 2-hydroxypropyl methacrylate (HPMA) with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) has been studied in aqueous solution at 60℃. Azo-bis-isobutyronitrile(AIBN) has been used as an initiator. The compositions of the copolymers were quantitatively determined by the measurement of the unreacted hydroxyl group content by acetylation method. The reactivity ratios were calculated by Kelen-T d s method. The monomer reactivity ratios obtained are as follows: r₁=0.86 and r₂=0.90 for HEMA-AMPS system, r₁=0.89 and r₂=1.03 for HPMA-AMPS system. The calculated Q and e factors by Alfrey-Price method are Q₂=0.97, e₂=0.71 for HEMA-AMPS system and Q₂=0.94, e₂=0.50 for HPMA-AMPS system. The swelling quantities of the copolymer systems were measured at 25℃, 35℃ and 45℃, respectively. The characterization of the copolymer has been investigated by infrared spectroscopy and differential scanning calorimetry.

2-Hydroxyalkyl methacrylate 고분자는 의학용 생체 재료로써 고려되어 왔다. 이 고분자는 물에 팽윤되어 hydrogel이 되며 이러한 hydrogel은 burn dressing, soft contact lens, artificial membrane 등에 널리 사용되고 있다. α,α''-azo-bis-isobutyronitrile(AIBN)을 사용하여 60℃ 수용액 상에서 2-hydroxyethyl methacrylate(HEMA) 및 2-hydroxypropyl methacrylate(HPMA)를 2-acrylamido-2-methylpropane sulfonic acid(AMPS)와 라디칼 중합법에 의해서 공중합을 시켰다. 그 공중합체의 조성은 아세틸화 방법에 의해서 구했다. 그리고 Kelen-T d s 방법에 의해서 반응성비 r₁ 및 r₂를 구하고 Alfrey-Price 방법에 의해서 AMPS의 Q₂, e₂ 값을 구했다. 그 결과의 값은 아래와 같다. HEMA-AMPS에 대해서 r₁=0.86, r₂=0.90, Q₂=0.97, e₂=0.71 HEMA-AMPS에 대해서 r₁=0.89, r₂=1.03, Q₂=0.94, e₂=0.50 또한 그공중합체들의 물에 대한 팽윤성을 25℃, 35℃ 및 45℃에서 각각 측정하였고, 적외선 분광기와 열시차 분석기를 이용하여 그 공중합체의 특성을 조사 연구하였다.

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