Article
  • Preparation of Antioxidant Hydrogel Contact Lenses via Copolymerization of Dopamine Monomer
  • Jung-Min Yang#, Ho-Joong Kim*,#, and Byoung-Ki Cho

  • Department of Chemistry, Dankook University, Chungnam 31116, Korea
    *Department of Chemistry, Chosun University, Gwangju 61452, Korea

  • 도파민 단량체 공중합을 기반으로 하는 항산화 콘택트렌즈 제조
  • 양정민# · 김호중*,# · 조병기

  • 단국대학교 화학과, *조선대학교 화학과

Abstract

In this work, we prepared antioxidant hydrogel contact lenses through the copolymerization of a synthesized dopamine monomer, 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC). Three contact lenses were made by varying the weight ratio (0.1%, 0.3%, 0.5%) of dopamine monomer at a 5 wt% of MPC. The prepared lenses exhibited visible light transmittance values higher than 90%. In addition, they exhibited high water contents of about 50% and low contact angles (55o-63o), which indicated excellent hydrophilicity. The antioxidant activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The antioxidant lenses removed most of DPPH radicals within 1 h. The measured antioxidant activities are comparable to 98% of ascorbic acid. Consequently, the prepared antioxidant contact lenses showed excellent antioxidant activities, although a small amount of dopamine group was employed.


도파민 단량체를 합성한 후, 2-hydroxyethyl methacrylate(HEMA), ethylene glycol dimethacrylate(EGDMA), 2-methacryloyloxyethyl phosphorylcholine(MPC)과의 공중합을 통해 항산화 콘택트렌즈를 제조하였다. 렌즈 합성 시, 도파민 무게%를 0.1, 0.3, 0.5%로 조절하였고, MPC는 5%로 고정하여, 3종의 렌즈를 준비하였다. 제조된 렌즈들은 90% 이상의 가시광선 투과율을 보였다. 50% 정도의 함수율과 낮은 접촉각(55o-63o)을 통해 렌즈 친수성이 향상됨을 알 수 있었다. 라디칼 소거 분석법을 이용하여 항산화 특성을 확인한 결과, 0.1% 도파민 그룹을 포함하는 렌즈의 경우에도 반응 1시간만에 소거율이 90%까지 증가함을 알 수 있었다. 본 결과는 아스코빅산의 항산화 기능대비 98%에 해당하는 것으로, 제조된 콘택트렌즈의 우수한 항산화 능력을 나타낸다.


Keywords: hydrogel, contact lenses, antioxidant, dopamine, radical scavenging assay

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2019; 43(5): 787-792

    Published online Sep 25, 2019

  • 10.7317/pk.2019.43.5.787
  • Received on Jun 13, 2019
  • Revised on Jul 15, 2019
  • Accepted on Jul 16, 2019

Correspondence to

  • Byoung-Ki Cho
  • Department of Chemistry, Dankook University, Chungnam 31116, Korea

  • E-mail: chobk@dankook.ac.kr