Department of Chemistry, Dankook University, Chungnam 31116, Korea
*Department of Chemistry, Chosun University, Gwangju 61452, Korea
단국대학교 화학과, *조선대학교 화학과
In this work, we prepared antioxidant hydrogel contact lenses through the copolymerization of a synthesized dopamine monomer, 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC). Three contact lenses were made by varying the weight ratio (0.1%, 0.3%, 0.5%) of dopamine monomer at a 5 wt% of MPC. The prepared lenses exhibited visible light transmittance values higher than 90%. In addition, they exhibited high water contents of about 50% and low contact angles (55o-63o), which indicated excellent hydrophilicity. The antioxidant activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The antioxidant lenses removed most of DPPH radicals within 1 h. The measured antioxidant activities are comparable to 98% of ascorbic acid. Consequently, the prepared antioxidant contact lenses showed excellent antioxidant activities, although a small amount of dopamine group was employed.
도파민 단량체를 합성한 후, 2-hydroxyethyl methacrylate(HEMA), ethylene glycol dimethacrylate(EGDMA), 2-methacryloyloxyethyl phosphorylcholine(MPC)과의 공중합을 통해 항산화 콘택트렌즈를 제조하였다. 렌즈 합성 시, 도파민 무게%를 0.1, 0.3, 0.5%로 조절하였고, MPC는 5%로 고정하여, 3종의 렌즈를 준비하였다. 제조된 렌즈들은 90% 이상의 가시광선 투과율을 보였다. 50% 정도의 함수율과 낮은 접촉각(55o-63o)을 통해 렌즈 친수성이 향상됨을 알 수 있었다. 라디칼 소거 분석법을 이용하여 항산화 특성을 확인한 결과, 0.1% 도파민 그룹을 포함하는 렌즈의 경우에도 반응 1시간만에 소거율이 90%까지 증가함을 알 수 있었다. 본 결과는 아스코빅산의 항산화 기능대비 98%에 해당하는 것으로, 제조된 콘택트렌즈의 우수한 항산화 능력을 나타낸다.
Keywords: hydrogel, contact lenses, antioxidant, dopamine, radical scavenging assay
2019; 43(5): 787-792
Published online Sep 25, 2019
Department of Chemistry, Dankook University, Chungnam 31116, Korea