Article
  • Development of Shark Cartilage Extracts Loaded Hydrogel for the Stomatitis Treatment

  • Eun-Jee Park#, Min-Suk Kook*,#, Jin Kim**,† , and Ki-Young Lee***,†

  • Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 61186, Korea
    *Department of Oral and Maxillofacial Surgery, Chonnam National University School of Dentistry, Gwangju 61186, Korea
    **Department of Oral and Maxillofacial Surgery, College of Dentistry, Chosun University & Institute of Dental Science,
    Chosun University, Gwangju 61452, Korea
    ***School of Chemical Engineering, Chonnam National University, Gwangju 61186, Korea

  • 상어 연골 추출물이 함유된 구내염 치료용 하이드로젤의 개발

  • 박은지# · 국민석*,# · 김 진**,† · 이기영***,†

  • 전남대학교 신화학소재공학과, *전남대학교 치의학 전문대학원 구강악안면외과학교실, **조선대학교 치과대학 구강악안면외과학교실 & 조선대학교 치의학연구원, ***전남대학교 화학공학부

Abstract

oly(vinyl alcohol) (PVA) hydrogel containing shark cartilage extract was prepared by freezing-thawing method for the treatment of stomatitis. The properties of hydrogel were evaluated by FTIR (Fourier transform infrared spectroscopy), EDS (energy-dispersive X-ray spectroscopy), surface pH, contact angle, and bio-adhesive strength. PVA/SCE hydrogel was found to have adhesion in the oral mucous membrane. PVA/SCE (shark cartilage extracts) hydrogel was attached to a hamster with oral ulcers. We have identified a higher ulcer healing effect with the treatment of the PVA/SCE hydrogel than the control group.


구내염 치료를 위해 상어 연골 추출물(SCE)을 포함하는 poly(vinyl alcohol)(PVA) 하이드로젤을 동결-융해 방법으로 제조하였다. 하이드로젤의 특성은 FTIR(Fourier transform infrared spectroscopy), EDS(energy-dispersive X-ray spectroscopy), 표면 pH, 접촉각, 생체점착강도를 통해 평가하였다. PVA/SCE 하이드로젤은 PVA 하이드로젤보다 구강점막에 대해 점막점착력이 있는 것을 확인하였다. 시리안 햄스터에 구강궤양을 유발한 후 PVA/SCE(shark cartilage extracts) 하이드로젤을 처치했을 때 대조군 그룹보다 높은 궤양 치유 효과를 확인하였다.


Keywords: poly(vinyl alcohol), hydrogel, shark cartilage, stomatitis, oral delivery system

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2019; 43(3): 365-371

    Published online May 25, 2019

  • 10.7317/pk.2019.43.3.365
  • Received on Jan 7, 2019
  • Revised on Feb 11, 2019
  • Accepted on Feb 12, 2019

Correspondence to

  • Jin Kim**, and Ki-Young Lee***

  • Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 61186, Korea
    **Department of Oral and Maxillofacial Surgery, College of Dentistry, Chosun University & Institute of Dental Science,
    Chosun University, Gwangju 61452, Korea
    ***School of Chemical Engineering, Chonnam National University, Gwangju 61186, Korea

  • E-mail: cream4251@chosun.ac.kr, kilee@jnu.ac.kr