Article
  • Evaluation of Gellan Gum/Glycol Chitosan Bioabsorbable Membrane for Guided Bone Regeneration

  • Jin-Woon Jang#, Jin Kim*,#, Min-Suk Kook**, and Ki-Young Lee***,†

  • Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 61186, Korea
    *Research Center for Healthcare-Biomedical Engineering, Chonnam National University, Yeosu 59626, Korea
    **Department of Oral and Maxillofacial Surgery, Chonnam National University School of Dentistry, Gwangju 61186, Korea
    ***School of Chemical Engineering and Biocosmos Co., Chonnam National University, Gwangju 61186, Korea

  • 골유도재생을 위한 젤란검과 글리콜 키토산 조성 흡수성 차폐막의 평가

  • 장진운# · 김 진*,# · 국민석** · 이기영***,†

  • 전남대학교 신화학소재공학과, *헬스케어의공학연구소, **전남대학교 치의학전문대학원 구강악안면외과학교실, ***전남대학교 화학공학부 & ㈜바이오코스모스

Abstract

Bioabsorbable membrane was prepared using gellan gum (GEL)-glycol chitosan (GC) with phosphate-buffered saline (PBS) as a crosslinker for guided bone regeneration (GBR). The GEL/GC membrane was characterized by Fourier transform infrared (FTIR), degradation, contact angle, tensile strength and cell viability. The result showed that by increasing the GC content in GEL membrane, the degradable and mechanical properties were decreased. New bone was observed through micro-CT and histological evaluation of forming a defect in rat calvarial and fixing the membrane. The amount of newbone regeneration was significantly greater in GEL/GC group than the control. The GEL/GC membrane blocked the soft tissue and has effects on the new bone formation.


골유도재생을 위해 젤란검(GEL)과 글리콜 키토산(GC) 조성막을 완충생리식염수(PBS)로 가교시켜 흡수성 차폐막(GBR)을 제조하였다. GEL/GC 조성막의 특성 분석을 위해 푸리에 변환 적외선 분광학, 분해도, 접촉각, 인장강도, 세포생존율을 평가하였다. 결과적으로 GEL 조성막에 GC의 함량이 증가할수록 막의 분해율 및 물리적 특성이 감소하였다. 랫 두개골에 결손부를 형성하여 흡수성 차폐막을 고정시켜 마이크로 CT, 조직학적 평가를 통해 신생골을 관찰하였다. 신생골 재생의 양은 GEL/GC 군이 대조군보다 유의하게 더 컸다. GEL/GC 흡수성 차폐막은 연조직을 차단하고 새로운 골형성에 효과가 있는 것을 확인하였다.


Keywords: gellan gum, glycol chitosan, membrane, guided bone regeneration

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2018; 42(5): 874-881

    Published online Sep 25, 2018

  • 10.7317/pk.2018.42.5.874
  • Received on Apr 24, 2018
  • Revised on May 22, 2018
  • Accepted on May 23, 2018

Correspondence to

  • Ki-Young Lee

  • School of Chemical Engineering and Biocosmos Co., Chonnam National University, Gwangju 61186, Korea

  • E-mail: kilee@jnu.ac.kr