Article
  • A New Concept Oral Care Patch with an Easily Removable Brush-off Film for More Convenient and Comfortable Use
  • Kim JY, Bang SE, Ahn JH, PArk JW, Jung YJ
  • 사용자 편의성 향상을 위한 새로운 개념의 브러쉬-오프 필름 기반 구강 케어 패치
  • 김지영, 방성은, 안재현, 박종원, 정용주
Abstract
As the first study to develop a brush-off type oral care patch, the polymer-blended films composed of ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC) were prepared by a solvent casting method. Contact angle measurements, tensile strength tests and optical topography measurements were performed to assess the suitability of the polymer blends as a brush-off patch film. The physicochemical properties of the polymer films were dependent profoundly on their composition. The morphologies of the blended polymer film were significantly altered upon contact with water over time. In terms of mechanical strength and hydration property, the polymer-blended films of EC and HPMC with a mass ratio of 1:1 or 2:1 were found to be highly suitable for a 30 min brush-off patch. We believe that this study can provide a new and versatile methodology of both designing and evaluating a brush-off film patch for oral care substance delivery.

브러쉬-오프 타입 구강 케어 패치 개발에 관한 최초의 연구로서, 에틸 셀룰로오스(EC)와 하이드록시프로필메틸셀룰로오스(HPMC)로 구성된 고분자 블렌드 필름을 solvent casting 방법으로 제조하였다. 고분자 블렌드 필름의 브러쉬-오프 패치로서의 적합성을 평가하기 위해 접촉각 측정, 인장강도 시험 및 광학현미경을 이용한 수화 시간에 따른 표면 형상 변화 측정 등을 수행하였다. 본 연구에서 측정된 표면 특성, 인장강도 및 수화 특성 등과 같은 필름의 물리화학적 특성은 고분자 조성에 크게 의존하는 것으로 나타났다. 무엇보다도, 기계적 물성과 수화 특성 측면에서 EC와 HPMC가 1:1 또는 2:1의 비율로 제조된 고분자 블렌드 필름이 30분 브러쉬-오프 패치로서 가장 적합한 것으로 나타났다. 이 연구는 브러쉬-오프 필름 패치를 디자인하고 평가하는 구강 케어 성분 전달 관련 연구분야에 새로운 방법론을 제시할 것으로 기대한다.

Keywords: brush-off film; oral care patch; polymer blend; ethyl cellulose; hydroxypropyl methylcellulose

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2017; 41(5): 784-789

    Published online Sep 25, 2017

  • 10.7317/pk.2017.41.5.784
  • Received on Feb 17, 2017
  • Accepted on May 1, 2017