Article
  • Adhesion Barrier of Methylcellulose Based Thermo-Responsive Sol-Gel
  • Kim J, Cheon SY, Shin DI, Lee CM, Lee KY
  • Methylcellulose 조성 온도 감응성 졸-젤 유착방지제
  • 김진, 천서영, 신동일, 이창문, 이기영
Abstract
Thermo-responsive sol-gel was prepared from methylcellulose (MC) and xanthan gum (XT) for adhesion barrier. The prepared MC/XT sol-gel showed transition temperature and gelation around body temperature (37 °C) within 1 min. In vivo biocompatibility and biodegradability of the MC/XT sol-gel were validated by implantation of the gel in rats. Also, the MC/XT sol-gel was highly effective for the prevention of tissue and organ adhesion. Therefore, the MC/XT sol-gel can be a good candidate material as a tissue adhesion barrier.

유착방지막을 제조하기 위해 methylcellulose(MC)와 xanthan gum(XT) 조성의 온도 감응성 졸-젤을 제조하였다. MC/XT 졸(sol)은 사람의 신체온도(37 °C)에서 1분 안에 젤화(gelation)가 일어나는 것을 보였다. Rat에 온도 감응성 졸-젤을 주입하여 생체적합성 및 생체분해성을 확인하였다. 또한 온도 감응성 졸-젤이 장기 및 조직의 유착방지에 효과가 높은 것을 관찰하였다. 그 결과 MC/XT 졸-젤은 조직 유착방지막의 좋은 후보 물질임을 확인하였다.

Keywords: methylcellulose; xanthan gum; sol-gel; adhesion barrier

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2017; 41(2): 318-323

    Published online Mar 25, 2017

  • 10.7317/pk.2017.41.2.318
  • Received on Nov 12, 2016
  • Accepted on Dec 23, 2016