Article
  • Dissolution Properties of Lercanidipine Solid Dispersion Manufactured Water . Soluble Polymer PVP K-30
  • Jeong HK, Park JY, Kim SY, Cha SR, Lee SE, Jang NK, Lee WT, Lee JP, Song JE, Khang G
  • 수용성 고분자 PVP K-30로 제조된 레르카니디핀 고체분산체의 용출 특성
  • 정현기, 박진영, 김수영, 차세롬, 이선의, 장나금, 이원택, 이진표, 송정은, 강길선
Abstract
Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine, which opens the blood vessels for allowing the blood to circulate more freely around the body. Lercanidipine is a poorly water soluble drug and quite difficult to deliver. Taking this into account, in the study, we have designed lercanidipine loaded water soluble polymer PVP K-30 via solid dispersion method using spray drying and rotary evaporation to improve the dissolution properties. Further, the dissolution behavior of the materials were evaluated by in vitro assays. Results showed that solid dispersion has increased the dissolution properties of the materials owing to the change in the drug chemical structure.

레르카니디핀 염산염은 디하이드로 피리딘의 칼슘채널 차단제로서 혈액이 체내에서 더 자유롭게 순환할 수 있도록 혈관을 확장시켜주는 고혈압 치료제이다. 레르카니디핀은 난용성 약물로 약물 전달 시스템에 적용하는데에 어려움이 많다. 이번 연구에 있어서 우리는 레르카니디핀에 수용성 고분자인 PVP K-30을 첨가하여 용출률을 개선시키기 위한 방법으로 분무건조와 회전증발법을 이용한 고체 분산체를 제조하였다. 또한 물질의 방출 거동은 invitro로 평가하였으며 재료의 용출 거동 결과에서 고체분산체는 약물의 화학 구조 변화로 인하여 물질의 용해도가 증가되는 것으로 나타났다.

Keywords: lercanidipine; PVP K30; solid dispersion; spray drying; rotary evaporation

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2016; 40(1): 33-41

    Published online Jan 25, 2016

  • 10.7317/pk.2016.40.1.33
  • Received on Jul 14, 2015
  • Accepted on Sep 9, 2015