Review
  • Biodegradable Nanoparticles for Nanomedicines
  • Kim MS, Park SJ, Gu BK, Kim CH
  • 나노의학용 생분해성 나노입자
  • 김민섭, 박상준, 구본강, 김천호
Abstract
Biodegradable polymeric nanoparticles (NPs) have shown significant therapeutic potential as nanomedicines for delivery of pharmaceutical agents. NPs made of biodegradable polymers can efficiently deliver drugs for sustained, controlled and targeted release, enhancing the stability of hydrophilic bioactive molecules, thereby improving their therapeutic efficacy while reducing their side effects. This paper reviews candidate biodegradable materials for NPs, including proteins and polysaccharides, and their methods of NP fabrication for nanomedicines.

최근 들어 나노의학에 사용되는 생분해성 나노입자는 치료용 제제를 효과적으로 전달하기 위한 전달체로 큰 주목을 받고 있다. 특히, 생분해성 고분자를 기반으로 제조한 나노입자는 친수성 담지 약물의 안정성 유지한 상태로 약물을 전달하고자 하는 부위로 찾아가 약물의 서방형 방출거동을 통해 약물의 효과를 극대화하며 약물에 의한 부작용을 최소화해야 할 것이다. 따라서 본 고에서는 나노의학에 응용이 가능한 생분해성 물질인 단백질과 다당류 등과 같은 천연고분자에 대한 소개와 이를 이용한 나노입자의 제조 방법에 대해 소개하였다.

Keywords: biodegradable nanoparticles; polymeric nanoparticles; nanomedicine; drug delivery; tissue engineering

References
  • 1. Parveen S, Misra R, Sahoo SK, Nanomedicine: NBM, 8, 147 (2012)
  •  
  • 2. Chow EKH, Ho D, Sci. Transl. Med., 5, 216rvs (2013)
  •  
  • 3. Kompella UB, Amrite AC, Ravi RP, Durazo SA, Prog. Retin. Eye Res., 36, 172 (2013)
  •  
  • 4. Chacko RT, Ventura J, Zhuang J, Thayumanavan S, Adv. Drug Deliv. Rev., 64, 836 (2012)
  •  
  • 5. Mahapatro A, Singh DK, J. Nanobiotechnology, 9, 1 (2011)
  •  
  • 6. Nishimura Y, Ishii J, Ogino C, Kondo A, J. Biomed. Nanotechnol., 10, 2063 (2014)
  •  
  • 7. Nitta SK, Numata K, Int. J. Mol. Sci., 14, 1629 (2013)
  •  
  • 8. Arshady R, J. Control. Release, 14, 111 (1990)
  •  
  • 9. Munshi N, De TK, Maitra A, J. Colloid Interface Sci., 190(2), 387 (1997)
  •  
  • 10. Troster S, Muller U, Kreuter J, Int. J. Pharm., 61, 85 (1990)
  •  
  • 11. Couvreur P, Kante B, Grislain L, Roland M, Speiser P, J. Pharm. Sci., 71, 790 (1982)
  •  
  • 12. Govender T, Stolnik S, Garnett MC, Illum L, Davis SS, J. Control. Release, 57, 171 (1999)
  •  
  • 13. Yoo HS, Lee KH, Oh JE, Park TG, J. Control. Release, 68, 419 (2000)
  •  
  • 14. Langer R, Tirrell DA, Nature, 428, 487 (2004)
  •  
  • 15. Hu J, Zhang G, Liu S, Chem. Soc. Rev., 41, 5933 (2012)
  •  
  • 16. Bamrungsap S, Zhao Z, Chen T, Wang L, Li C, Fu T, Tan W, Nanomedicine, 7, 1253 (2012)
  •  
  • 17. Vashist A, Vashist A, Gupta Y, Ahmad S, J. Mater. Chem. B, 2, 147 (2014)
  •  
  • 18. Hosseinkhani H, He WJ, Chiang CH, Hong PD, Yu DS, Domb AJ, Ou KL, J. Nanopart. Res., 15, 1 (2013)
  •  
  • 19. Yewale C, Baradia D, Vhora I, Misra A, Expert Opin. Drug Del., 10, 1429 (2013)
  •  
  • 20. Glenn GM, Smith G, Fries L, Raghunandan R, Lu H, Zhou B, Thomas DN, Hickman SP, Kpamegan E, Boddapati S, Vaccine, 31, 524 (2013)
  •  
  • 21. Subia B, Kundu S, Nanotechnology, 24, 035103 (2013)
  •  
  • 22. Forbes BA, Hicks KE, J. Clin. Microbiol., 34, 2125 (1996)
  •  
  • 23. Kouchakzadeh H, Shojaosadati SA, Tahmasebi F, Shokri F, Int. J. Pharm., 447, 62 (2013)
  •  
  • 24. Li M, McAuley E, Zhang Y, Kong L, Yang F, Zhou Z, Wu X, Liang H, Chem. Biol. Drug Des., 83, 576 (2014)
  •  
  • 25. Jiang Y, Liang M, Svejkar D, Hart-Smith G, Lu H, Scarano W, Stenzel MH, Chem. Commun., 50, 6394 (2014)
  •  
  • 26. Langiu M, Dadparvar M, Kreuter J, Ruonala MO, PLOS ONE, 9, e10760 (2015)
  •  
  • 27. Peluffo H, Unzueta U, Negro-Demontel MLND, Xu Z, Vaquez E, Ferrer-Miralles N, Villaverde A, Biotechnol. Adv., 33, 277 (2015)
  •  
  • 28. Cha SR, Jeong HK, Kim SY, Kim EY, Song JE, Park CH, Kwon SY, Khang G, Polym.(Korea), 39(3), 493 (2015)
  •  
  • 29. Lee JH, El-Fiqi A, Han CM, Kim HW, Tissue Eng. Regen. Med., 12, 90 (2015)
  •  
  • 30. Kasoju N, Ali SS, Dubey VK, Bora U, J. Proteins & Proteomics, 1, 9 (2010)
  •  
  • 31. Ernsting MJ, Murakami M, Roy A, Li SD, J. Control. Release, 172, 782 (2013)
  •  
  • 32. Ahn G, Moon JY, Lee I, Yoon S, Lee D, Macromol. Res., 22(9), 1024 (2014)
  •  
  • 33. Elzoghby AO, J. Control. Release, 172, 1075 (2013)
  •  
  • 34. Kim MK, Lee KH, Polym.(Korea), 38(1), 98 (2014)
  •  
  • 35. Jeong L, Cho D, Kwon OH, Min BM, Park WH, Macromol. Res., 22(7), 796 (2014)
  •  
  • 36. Ju HW, Lee OJ, Moon BM, Sheikh FA, Lee JM, Kim JH, Park HJ, Kim DW, Lee MC, Kim SH, Tissue Eng. Regen. Med., 11, 203 (2014)
  •  
  • 37. Mottaghitalab F, Farokhi M, Shokrgozar MA, Atyabi F, Hosseinkhani H, J. Control. Release, 206, 161 (2015)
  •  
  • 38. Tamayol A, Akbari M, Annabi N, Paul A, Khademhosseini A, Juncker D, Biotechnol. Adv., 31, 669 (2013)
  •  
  • 39. Gopinath H, Venugopal KS, Shanmugasundaram S, Shanmugam D, Elixir Appl. Chem., 58, 14551 (2013)
  •  
  • 40. Khosa MA, Shah SS, Feng XS, Chem. Eng. J., 244(-), 446 (2014)
  •  
  • 41. Kundu B, Kurland NE, Bano S, Patra C, Engel FB, Yadavalli VK, Kundu SC, Prog. Polym. Sci, 39, 251 (2014)
  •  
  • 42. Lee H, Noh K, Lee SC, Kwon IK, Han DW, Lee IS, Hwang YS, Tissue Eng. Regen. Med., 11, 255 (2104)
  •  
  • 43. Vasconcelos A, Cavaco-Paulo A, Curr. Drug Targets, 14, 612 (2013)
  •  
  • 44. Ganguly K, Chaturvedi K, More UA, Nadagouda MN, Aminabhavi TM, J. Control. Release, 193, 162 (2014)
  •  
  • 45. Croisier F, Jerome C, Eur. Polym. J., 49, 780 (2013)
  •  
  • 46. Park JK, Choi C, Nam JP, Park SC, Park YH, Jang MK, Nah JW, Polym.(Korea), 38(1), 85 (2014)
  •  
  • 47. Hsu LW, Ho YC, Chuang EY, Chen CT, Juang JH, Su FY, Hwang SM, Sung HW, Biomaterials, 34, 784 (2013)
  •  
  • 48. Skop NB, Calderon F, Levison SW, Gandhi CD, Cho CH, Acta Biomater., 9, 6834 (2013)
  •  
  • 49. Park JK, Nah JW, Choi C, Polym.(Korea), 39(3), 480 (2015)
  •  
  • 50. de Britto D, de Moura MR, Aouada FA, Pinola FG, Lundstedt LM, Assis OBG, Mattoso LHC, Macromol. Res., 22(12), 1261 (2014)
  •  
  • 51. Kim H, Lee E, Lee IH, Lee J, Kim J, Kim S, Lee Y, Kim D, Choi M, Kim YC, Jon S, Macromol. Res., 22(8), 805 (2014)
  •  
  • 52. Alva E, Turan SO, Kabasakal L, Alan S, Ozkan N, Eren F, Akbuga J, J. Pharm. Sci., 103, 785 (2014)
  •  
  • 53. Bidarra SJ, Barrias CC, Granja PL, Acta Biomater., 10, 1646 (2014)
  •  
  • 54. Lee SH, Chung HY, Shin HI, Park DJ, Choi JH, Tissue Eng. Regen. Med., 11, 106 (2014)
  •  
  • 55. Kim HM, Park JY, Kim EY, Song JE, Kwon SY, Chung JW, Khang G, Polym.(Korea), 38(3), 278 (2014)
  •  
  • 56. Ma Y, Coombes AG, J. Biomed. Mater. Res. Part A, 102, 3167 (2014)
  •  
  • 57. Guo H, Lai Q, Wang W, Wu Y, Zhang C, Liu Y, Yuan Z, Int. J. Pharm., 451, 1 (2013)
  •  
  • 58. Lepeltier E, Bourgaux C, Couvreur P, Adv. Drug Deliv. Rev., 71, 86 (2014)
  •  
  • 59. Zhang Y, Chan HF, Leong KW, Adv. Drug Deliv. Rev., 65, 104 (2013)
  •  
  • 60. Campardelli R, Cherain M, Perfetti C, Iorio C, Scognamiglio M, Reverchon E, Della Porta G, J. Supercrit. Fluids, 82(-), 34 (2013)
  •  
  • 61. Sripriyalakshmi S, Jose P, Ravindran A, Anjali C, Cell Biochem. Biophys., 70, 17 (2014)
  •  
  • 62. Battaglia L, Gallarate M, Peira E, Chirio D, Solazzi I, Giordano SMA, Gigliotti CL, Riganti C, Dianzani C, Nanotechnology, 26, 255102 (2015)
  •  
  • 63. Hudson D, Margaritis A, Crit. Rev. Biotechnol., 34, 161 (2014)
  •  
  • 64. Sridhar R, Lakshminarayanan R, Madhaiyan K, Barathi VA, Lim KHC, Ramakrishna S, Chem. Soc. Rev., 44, 790 (2015)
  •  
  • 65. Kim BJ, Cheong H, Hwang BH, Cha HJ, Angew. Chem.-Int. Edit., 127, 7426 (2015)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2015; 39(6): 831-836

    Published online Nov 25, 2015

  • 10.7317/pk.2015.39.6.831
  • Received on Jun 10, 2015
  • Accepted on Jun 18, 2015