Article
  • Thermosensitive Chitosan-based Hydrogel with Growth Factor as Adhesion Barrier
  • Park JK, Nah JW, Choi C
  • 성장인자/키토산이 담지된 온도감응성 하이드로젤의 유착방지제로서의 응용
  • 박준규, 나재운, 최창용
Abstract
The adhesion of tissue and organ occur with frequency after surgery. Theomosensitive hydrogel was prepared from poloxamer/chitosan/epidermal growth factor as adhesion barrier agent. The prepared hydrogel showed sol-gel transition temperatures around human temperature and gelation temperature was the faster within 1 min. The hydrogel sustained the release of epidermal grow factor during 7 days. The hydrogel was highly effective for the prevention of tissue and organ adhesion in rat model. The thermosensitive and antibacterial chitosan hydrogel can be useful to consider the anti-adhesion barrier with increased adhesion of organ and sustained release of epidermal growth factor.

조직과 장기 유착은 외과적 수술 후 부작용으로 자주 발생된다. 이러한 조직 유착을 방지하기 위하여 유착부위에 장벽을 형성하여 장기 유착을 방지할 수 있는 온도감응성 하이드로젤 유착방지제를 제조하고자하였다. 폴록사머, 키토산과 표피성장인자를 가지고 온도감응성 키토산 하이드로젤을 제조하였다. 제조한 키토산 하이드로젤은 인체 내 온도와 유사한 35 oC에서 졸-젤 전이현상을 보였고, 1분 이내에 빠르게 젤화되었다. 키토산 하이드로젤은 표피성장인자를 7일 동안 천천히 방출하였고, 마우스모델에서 평가한 결과 조직 유착 방지를 효과적으로 하는 것을 확인하였다. 온도 감응성과 항균성을 갖는 키토산 하이드로젤이 장기 부착의 증가와 표피성장인자를 천천히 방출하는 유착방지제로서 유용하게 사용될 수 있다.

Keywords: poloxamer; chitosan; tissue anti-adhesion; hydrogel; epidermal growth factor

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This Article

  • 2015; 39(3): 480-486

    Published online May 25, 2015

  • 10.7317/pk.2015.39.3.480
  • Received on Oct 13, 2014
  • Accepted on Nov 19, 2014