Review
  • Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine
  • Lee SJ, Yoo JJ, Atala A
  • 고분자 생체재료와 줄기세포를 이용한 조직공학과 재생의학의 최신 동향
  • 이상진, Yoo JJ, Atala A
Abstract
Tissue engineering and regenerative medicine strategies could offer new hope for patients with serious tissue injuries or end-stage organ failure. Scientists are now applying the principles of cell transplantation, material science, and engineering to create biological substitutes that can restore and maintain normal function in diseased or injured tissues/organs. Specifically, creation of engineered tissue construct requires a polymeric biomaterial scaffold that serves as a cell carrier, which would provide structural support until native tissue forms in vivo. Even though the requirements for scaffolds may be different depending on the target applications, a general function of scaffolds that need to be fulfilled is biodegradability, biological and mechanical properties, and temporal structural integrity. The scaffold's internal architecture should also enhance the permeability of nutrients and neovascularization. In addition, the stem cell field is advancing, and new discoveries in tissue engineering and regenerative medicine will lead to new therapeutic strategies. Although use of stem cells is still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous adult cells have already entered the clinic. This review discusses these tissue engineering and regenerative medicine strategies for various tissues and organs.

Keywords: biomaterials; polymers; extracellular matrix; stem cells; tissue engineering; regenerative medicine.

References
  • 1. Atala A, Curr. Opin. Biotechnol., 20, 575 (2009)
  •  
  • 2. Atala A, Urol. Clin. North Am., 36, 199 (2009)
  •  
  • 3. Atala A, Fertil. Steril., 98, 21 (2012)
  •  
  • 4. Atala A, Kasper FK, Mikos AG, Sci. Transl. Med., 4, 160rv1 (2012)
  •  
  • 5. Chen F, Yoo JJ, Atala A, Urology, 54, 407 (1999)
  •  
  • 6. Chun SY, Lim GJ, Kwon TG, Kwak EK, Kim BW, Atala A, Yoo JJ, Biomaterials, 28, 4251 (2007)
  •  
  • 7. Yoo JJ, Meng J, Oberpenning F, Atala A, Urology, 51, 221 (1998)
  •  
  • 8. Eberli D, Susaeta R, Yoo JJ, Atala A, Int. J. Impot. Res., 19, 602 (2007)
  •  
  • 9. Kim BS, Atala A, Yoo JJ, World. J. Urol., 26, 307 (2008)
  •  
  • 10. Joo S, Ko IK, Atala A, Yoo JJ, Lee SJ, Arch. Pharm. Res., 35, 271 (2012)
  •  
  • 11. Bergsma JE, Rozema FR, Bos RR, Boering G, de Bruijn WC, Pennings AJ, Biomaterials, 16, 267 (1995)
  •  
  • 12. Hynes RO, Cell, 69, 11 (1992)
  •  
  • 13. Deuel TF, Annu. Rev. Cell. Biol., 3, 443 (1987)
  •  
  • 14. Kim BS, Mooney DJ, Trends Biotechnol., 16, 224 (1998)
  •  
  • 15. Pariente JL, Kim BS, Atala A, J. Urol., 167, 1867 (2002)
  •  
  • 16. Lee CH, Singla A, Lee Y, Int. J. Pharm., 221, 1 (2001)
  •  
  • 17. Patino MG, Neiders ME, Andreana S, Noble B, Cohen RE, J. Oral. Implantol., 28, 220 (2002)
  •  
  • 18. van Susante JLC, Pieper J, Buma P, van Kuppevelt TH, van Beuningen H, van Der Kraan PM, Veerkamp JH, van den Berg WB, Veth RPH, Biomaterials, 22, 2359 (2001)
  •  
  • 19. Murray MM, Rice K, Wright RJ, Spector M, J. Orthop. Res., 21, 238 (2003)
  •  
  • 20. Coviello T, Matricardi P, Marianecci C, Alhaique F, J. Control. Release, 119, 5 (2007)
  •  
  • 21. Spicer AP, Tien JY, Birth Defects Res. C, 72, 89 (2004)
  •  
  • 22. Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG, Dis. Colon. Rectum., 46, 1310 (2003)
  •  
  • 23. Diamond MP, Fertil. Steril., 66, 904 (1996)
  •  
  • 24. Kemper F, Gebhardt U, Meng T, Murray C, Curr. Med. Res. Opin., 21, 1261 (2005)
  •  
  • 25. Waddell DD, Bricker DC, Hylan GF, J. Surg. Orthop. Adv., 15, 53 (2006)
  •  
  • 26. Waddell DD, Bricker DC, J. Knee Surg., 19, 19 (2006)
  •  
  • 27. Khor E, Lim LY, Biomaterials, 24, 2339 (2003)
  •  
  • 28. Shi C, Zhu Y, Ran X, Wang M, Su Y, Cheng T, J. Surg. Res., 133, 185 (2006)
  •  
  • 29. Tonnesen HH, Karlsen J, Drug Dev. Ind. Pharm., 28, 621 (2002)
  •  
  • 30. Gutowska A, Jeong B, Jasionowski M, Anat. Rec., 263, 342 (2001)
  •  
  • 31. Zimmermann H, Zimmermann D, Reuss R, Feilien PJ, Manz B, Katsen A, Weber M, Ihmig FR, Ehrhart F, Gessner P, Behringer M, Steinbach A, Wegner LH, Sukhorukov VL, Vasquez JA, Schneider S, Weber MM, Volke F, Wolf R, Zimmermann U, J. Mater. Sci. -Mater. Med., 16, 491 (2005)
  •  
  • 32. Jones PL, Schmidhauser C, Bissell MJ, Crit. Rev. Eukaryot. Gene Expr., 3, 137 (1993)
  •  
  • 33. Juliano RL, Haskill S, J. Cell. Biol., 120, 577 (1993)
  •  
  • 34. Reid L, Morrow B, Jubinsky P, Schwartz E, Gatmaitan Z, Ann. N. Y. Acad. Sci., 372, 354 (1981)
  •  
  • 35. Birkedal-Hansen H, Curr. Opin. Cell Biol., 7, 728 (1995)
  •  
  • 36. Lutolf MP, Nat. Biotechnol., 23, 47 (2005)
  •  
  • 37. Hodde J, Tissue Eng., 8, 295 (2002)
  •  
  • 38. Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA, Nat. Med., 14, 213 (2008)
  •  
  • 39. Eberli D, Atala A, Yoo JJ, J. Mater. Sci. -Mater. Med., 22, 741 (2010)
  •  
  • 40. Baptista PM, Siddigui MM, Lozier G, Rodriguez SR, Atala A, Soker S, Hepatology, 53, 604 (2010)
  •  
  • 41. Ott HC, Clippinger B, Conrad C, Schuetz C, Pomerantseva I, Ikonomou L, Kotton D, Vacanti JP, Nat. Med., 16, 927 (2010)
  •  
  • 42. Sullivan DC, Mirmalek-Sani SH, Deegan DB, Baptista PM, Aboushwareb T, Atala A, Yoo JJ, Biomaterials, 33, 7756 (2012)
  •  
  • 43. Sandusky GE, Lantz GC, Badylak SF, J. Surg. Res., 58, 415 (1995)
  •  
  • 44. DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL, PLoS One, 5, e13039 (2010)
  •  
  • 45. Stern MM, Myers RL, Hammam N, Stern KA, Eberli D, Kritchevsky SB, Soker S, van Dyke M, Biomaterials, 30, 2393 (2009)
  •  
  • 46. Gilbert TW, Sellaro TL, Badylak SF, Biomaterials, 27, 3675 (2006)
  •  
  • 47. Serrano MC, Pagani R, Vallet-Regi M, Pena J, Ramila A, Izquierdo I, Portoles MT, Biomaterials, 25, 5603 (2004)
  •  
  • 48. Gunatillake PA, Adhikari R, Eur. Cell Mater., 5, 1 (2003)
  •  
  • 49. Galaev IY, Mattiasson B, Trends Biotechnol., 17, 335 (1999)
  •  
  • 50. Hoffman AS, Stayton PS, Bulmus V, Chen G, Chen J, Cheung C, Chilkoti A, Ding Z, Dong L, Fong R, Lackey CA, Long CJ, Miura M, Morris JE, Murthy N, Nabeshima Y, Park TG, Press OW, Shimoboji T, Shoemaker S, Yang HJ, Monji N, Nowinski RC, Cole CA, Priest JH, , J. Biomed. Mater. Res., 52, 577 (2000)
  •  
  • 51. Cilento BG, Freeman MR, Schneck FX, Retik AB, Atala A, J. Urol., 152, 665 (1994)
  •  
  • 52. Liebert M, Hubbel A, Chung M, Wedemeyer G, Lomax MI, Hegeman A, Yuan TY, Brozovich M, Wheelock MJ, Grossman HB, Differentiation, 61, 177 (1997)
  •  
  • 53. Puthenveettil JA, Burger MS, Reznikoff CA, Adv. Exp. Med. Biol., 462, 83 (1999)
  •  
  • 54. Solomon LZ, Jennings AM, Sharpe P, Cooper AJ, Malone PS, J. Lab. Clin. Med., 132, 279 (1998)
  •  
  • 55. Brivanlou AH, Gage FH, Jaenisch R, Jessell T, Melton D, Rossant J, Science, 300, 913 (2003)
  •  
  • 56. Richards M, Fong CY, Chan WK, Wong PC, Bongso A, Nat. Biotechnol., 20, 933 (2002)
  •  
  • 57. Amit M, Margulets V, Segev H, Shariki K, Laevsky I, Coleman R, Itskovitz-Eldor J, Biol. Reprod., 68, 2150 (2003)
  •  
  • 58. Ludwig TE, Bergendahl V, Levenstein ME, Yu J, Probasco MD, Thomson JA, Nat. Methods, 3, 637 (2006)
  •  
  • 59. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM, Science, 282(5391), 1145 (1998)
  •  
  • 60. Reubinoff BE, Itsykson P, Turetsky T, Pera MF, Reinhartz E, Itzik A, Ben-Hur T, Nat. Biotechnol., 19, 1134 (2001)
  •  
  • 61. Schuldiner M, Eiges R, Eden A, Yanuka O, Itskovitz-Eldor J, Goldstein RS, Benvenisty N, Brain Res., 913, 201 (2001)
  •  
  • 62. Mummery CL, Zhang J, Ng ES, Elliott DA, Elefanty AG, Kamp TJ, Circ. Res., 111, 344 (2012)
  •  
  • 63. Cheung C, Sinha S, J. Mol. Cell. Cardiol., 51, 651 (2011)
  •  
  • 64. Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomsons JA, Proc. Natl. Acad. Sci., 98, 10716 (2001)
  •  
  • 65. Kehat I, Kenyagin-Karsenti D, Snir M, Segev H, Amit M, Gepstein A, Livne E, Binah O, Iskovitz-Eldor J, Gepstein L, J. Clin. Invest., 108, 407 (2001)
  •  
  • 66. Levenberg S, Golub JS, Amit M, Itskovitz-Eldor J, Langer R, Proc. Natl. Acad. Sci., 99, 4391 (2002)
  •  
  • 67. Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M, Diabetes, 50, 1691 (2001)
  •  
  • 68. Lie KH, Tuch BE, Sidhu KS, Pancreas, 41, 54 (2012)
  •  
  • 69. Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, Soreq H, Benvenisty N, Mol. Med., 6, 88 (2000)
  •  
  • 70. Takahashi K, Yamanaka S, Cell, 126, 663 (2006)
  •  
  • 71. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R, Nature, 448, 318 (2007)
  •  
  • 72. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S, Cell, 131, 861 (2007)
  •  
  • 73. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA, Science, 318, 1917 (2007)
  •  
  • 74. Okita K, Ichisaka T, Yamanaka S, Nature, 448, 313 (2007)
  •  
  • 75. Meissner A, Wernig M, Jaenisch R, Nat. Biotechnol., 25, 1177 (2007)
  •  
  • 76. Langer R, Vacanti JP, Science, 260, 920 (1993)
  •  
  • 77. Atala A, Rejuvenation Res., 7, 15 (2004)
  •  
  • 78. Lee SJ, Van Dyke M, Atala A, Yoo JJ, Rejuvenation Res., 11, 747 (2008)
  •  
  • 79. Jopling C, Boue S, Belmonte JCI, Nat. Rev. Mol. Cell. Biol., 12, 79 (2011)
  •  
  • 80. Bartsch G, Yoo JJ, De Coppi P, Siddiqui MM, Schuch G, Pohl HG, Fuhr J, Perin L, Soker S, Atala A, Stem. Cells Dev., 14, 337 (2005)
  •  
  • 81. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A, Nat. Biotechnol., 25, 100 (2007)
  •  
  • 82. Pan GJ, Chang ZY, Scholer HR, Pei D, Cell Res., 12, 321 (2002)
  •  
  • 83. Moorefield EC, McKee EE, Solchaga L, Orlando G, Yoo JJ, Walker S, Furth ME, Bishop CE, PLoS One, 6, e26535 (2011)
  •  
  • 84. Bach AD, Beier JP, Stern-Staeter J, Horch RE, J. Cell Mol. Med., 8, 413 (2004)
  •  
  • 85. DiEdwardo CA, Petrosko P, Acarturk TO, DiMilla PA, LaFramboise WA, Johnson PC, Clin. Plast. Surg., 26, 647 (1999)
  •  
  • 86. Cossu G, Biressi S, Semin. Cell Dev. Biol., 16, 623 (2005)
  •  
  • 87. Cao B, Deasy BM, Pollett J, Huard J, Phys. Med. Rehabil. Clin. N Am., 16, 889 (2005)
  •  
  • 88. Wernig A, Zweyer M, Irintchev A, J. Physiol., 522, 233 (2000)
  •  
  • 89. Cesar M, Roussanne-Domergue S, Coulet B, Gay S, Micallef JP, Chammas M, Reyne Y, Bacou F, Muscle Nerve, 37, 219 (2008)
  •  
  • 90. DeRosimo JF, Washabaugh CH, Ontell MP, Daood MJ, Watchko JF, Watkins SC, Ameredes BT, Ontell M, Cell Transplant., 9, 369 (2000)
  •  
  • 91. Payumo FC, Kim HD, Sherling MA, Smith LP, Powell C, Wang X, Keeping HS, Valentini RF, Vandenburgh HH, Clin. Orthop. Relat. Res., 403, s228 (2002)
  •  
  • 92. Powell CA, Smiley BL, Mills J, Vandenburgh HH, Am. J. Physiol. Cell Physiol., 283, C1557 (2002)
  •  
  • 93. Choi JS, Lee SJ, Christ GJ, Atala A, Yoo JJ, Biomaterials, 29, 2899 (2008)
  •  
  • 94. Wakelam MJ, Biochem. J., 228, 1 (1985)
  •  
  • 95. Zhao W, Ju YM, Christ G, Atala A, Yoo JJ, Lee SJ, Biomaterials, 34, 8235 (2013)
  •  
  • 96. Koning M, Harmsen MC, van Luyn MJ, Werker PM, J. TissJ. Tissue. Eng. Regen. Med., 3, 407 (2009)
  •  
  • 97. Kingham PJ, Terenghi G, J. Anat., 209, 511 (2006)
  •  
  • 98. Bian W, Bursac N, Faseb J., 26, 955 (2012)
  •  
  • 99. Kummer TT, Misgeld T, Sanes JR, Curr. Opin. Neurobiol., 16, 74 (2006)
  •  
  • 100. Wu H, Xiong WC, Mei L, Development, 137, 1017 (2010)
  •  
  • 101. Bach AD, Beier JP, Stark GB, Cell Tissue Res., 314, 263 (2003)
  •  
  • 102. Bentzinger CF, Barzaghi P, Lin S, Ruegg MA, Faseb J., 19, 934 (2005)
  •  
  • 103. Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR, Shah S, Mattsson K, Burden SJ, DiStefano PS, Valenzuela DM, DeChiara TM, Yancopulos GD, Cell, 85, 513 (1996)
  •  
  • 104. Lin S, Landmann L, Ruegg MA, Brenners HR, J. Neurosci., 28, 3333 (2008)
  •  
  • 105. DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, Kinetz E, Compton DL, Rojas E, Park JS, Smith C, DiStefano PS, Glass DJ, Burden SJ, Yancopoulos GD, Cell, 85, 501 (1996)
  •  
  • 106. Ko IK, Lee BK, Lee SJ, Andersson KE, Atala A, Yoo JJ, Biomaterials, 34, 3246 (2013)
  •  
  • 107. Ross R, Nature, 362, 801 (1993)
  •  
  • 108. Bujan J, Garcia-Honduvilla N, Bellon JM, Biotechnol. Appl. Biochem., 39, 17 (2004)
  •  
  • 109. Edelman ER, Circ. Res., 85, 115 (1999)
  •  
  • 110. Gong Z, Niklason LE, Trends Cardiovasc. Med., 16, 153 (2006)
  •  
  • 111. Greenwald SE, Berry CL, J. Pathol., 190, 292 (2000)
  •  
  • 112. Swain TW, 3rd, Calligaro KD, Dougherty MD, Vasc. Endovascular. Surg., 38, 75 (2004)
  •  
  • 113. Ju YM, Choi JS, Atala A, Yoo JJ, Lee SJ, Biomaterials, 31, 4313 (2010)
  •  
  • 114. Amiel GE, Komura M, Shapira O, Yoo JJ, Yazdani S, Berry J, Kaushal S, Bischoff J, Atala A, Soker S, Tissue Eng., 12, 2355 (2006)
  •  
  • 115. Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE, Nat. Med., 7, 1035 (2001)
  •  
  • 116. Drilling S, Gaumer J, Lannutti J, J. Biomed. Mater. Res., 88, 923 (2009)
  •  
  • 117. Lee SJ, Lim GJ, Lee JW, Atala A, Yoo JJ, Biomaterials, 27, 3466 (2006)
  •  
  • 118. Lee SJ, Yoo JJ, Lim GJ, Atala A, Stitzel J, J. Biomed. Mater. Res. A, 83, 999 (2007)
  •  
  • 119. Stitzel J, Liu J, Lee SJ, Komura M, Berry J, Soker S, Lim G, Van Dyke M, Czerw R, Yoo JJ, Atala A, Biomaterials, 27, 1088 (2006)
  •  
  • 120. Baguneid MS, Seifalian AM, Salacinski HJ, Murray D, Hamilton G, Walker MG, Br. J. Surg., 93, 282 (2006)
  •  
  • 121. Tillman BW, Yazdani SK, Lee SJ, Geary RL, Atala A, Yoo JJ, Biomaterials, 30, 583 (2009)
  •  
  • 122. Salgado AJ, Coutinho OP, Reis RL, Macromol. Biosci., 4, 743 (2004)
  •  
  • 123. Zaidi N, Nixon AJ, Ann. N. Y. Acad. Sci., 1117, 62 (2007)
  •  
  • 124. Rodrigues MT, Lee BK, Lee SJ, Gomes ME, Reis RL, Atala A, Yoo JJ, Biomaterials, 33, 6069 (2012)
  •  
  • 125. Rodrigues MT, Lee SJ, Gomes ME, Reis RL, Atala A, Yoo JJ, Tissue Eng. Part A, 18, 2518 (2012)
  •  
  • 126. Rodrigues MT, Lee SJ, Gomes ME, Reis RL, Atala A, Yoo JJ, Acta Biomaterialia, 8, 2795 (2012)
  •  
  • 127. Luo X, Yang J, Yang Q, Wang X, J. Craniofac. Surg., 23, 654 (2012)
  •  
  • 128. Yamada A, Imai K, Nomachi T, Fujimoto T, Morimoto K, Burns, 33, 112 (2007)
  •  
  • 129. Zhang Q, Quan Y, Su Y, Shi L, Xie Y, Liu X, Ann. Plast. Surg., 64, 428 (2010)
  •  
  • 130. Tanzer RC, Plast. Reconstr. Surg., 23, 1 (1959)
  •  
  • 131. Suutarla S, Rautio J, Klockars T, Facial Plast. Surg., 25, 164 (2009)
  •  
  • 132. Wilkes GH, Facial Plast. Surg., 25, 158 (2009)
  •  
  • 133. Siegert R, Magritz R, Facial Plast. Surg., 25, 169 (2009)
  •  
  • 134. Siegert R, Weerda H, Magritz R, Facial Plast. Surg., 25, 149 (2009)
  •  
  • 135. Sevin K, Askar I, Saray A, Yormuk E, Br. J. Oral Maxillofac. Surg., 38, 44 (2000)
  •  
  • 136. Williams JD, Romo T, 3rd, Sclafani AP, Cho H, Arch. Otolaryngol. Head Neck Surg., 123, 578 (1997)
  •  
  • 137. Cenzi R, Farina A, Zuccarino L, Carinci F, J. Craniofac. Surg., 16, 526 (2005)
  •  
  • 138. Sterodimas A, de Faria J, Correa WE, J. Plast. Reconstr. Aesthet. Surg., 62, 447 (2009)
  •  
  • 139. Lee SJ, Broda C, Atala A, Yoo JJ, Biomacromolecules, 12(2), 306 (2011)
  •  
  • 140. Auchincloss H, Bonventre JV, Nat. Biotechnol., 20, 665 (2002)
  •  
  • 141. Amiel GE, Yoo JJ, Atala A, World J. Urol., 18, 71 (2000)
  •  
  • 142. Aebischer P, Ip TK, Panol G, Galletti PM, Life Support Syst., 5, 159 (1987)
  •  
  • 143. Humes HD, Buffington DA, MacKay SM, Funke AJ, Weitzel WF, Nat. Biotechnol., 17, 451 (1999)
  •  
  • 144. Joki T, Machluf M, Atala A, Zhu J, Seyfried NT, Dunn IF, Abe T, Carroll RS, Black PM, Nat. Biotechnol., 19, 35 (2001)
  •  
  • 145. Lanza RP, Hayes JL, Chick WL, Nat. Biotechnol., 14, 1107 (1996)
  •  
  • 146. Lanza RP, Chung HY, Yoo JJ, Wettstein PJ, Blackwell C, Borson N, Hofmeister E, Schuch G, Soker S, Moraes CT, West MD, Atala A, Nat. Biotechnol., 20, 689 (2002)
  •  
  • 147. Bazeed MA, Thuroff JW, Schmidt RA, Tanagho EA, Urology, 21, 53 (1983)
  •  
  • 148. Olsen L, Bowald S, Busch C, Carlsten J, Eriksson I, Scand J. Urol. Nephrol., 26, 323 (1992)
  •  
  • 149. Atala A, Vacanti JP, Peters CA, Mandell J, Retik AB, Freeman MR, J. Urol., 148, 658 (1992)
  •  
  • 150. Sievert KD, Bakircioglu ME, Nunes L, Tu R, Dahiya R, Tanagho EA, J. Urol., 163, 1958 (2000)
  •  
  • 151. Atala A, Guzman L, Retik AB, J. Urol., 162, 1148 (1999)
  •  
  • 152. De Filippo RE, Yoo JJ, Atala A, J. Urol., 168, 1789 (2002)
  •  
  • 153. le Roux PJ, J. Urol., 173, 140 (2005)
  •  
  • 154. Raya-Rivera A, Esquiliano DR, Yoo JJ, Lopez-Bayghen E, Soker S, Atala A, Lancet, 377, 1175 (2011)
  •  
  • 155. Oberpenning F, Meng J, Yoo JJ, Atala A, Nat. Biotechnol., 17, 149 (1999)
  •  
  • 156. Atala A, Bauer SB, Soker S, Yoo JJ, Retik AB, Lancet, 367, 1241 (2006)
  •  
  • 157. Folkman J, Hochberg M, J. Exp. Med., 138, 745 (1973)
  •  
  • 158. Nomi M, Atala A, Coppi PD, Soker S, Mol. Aspects. Med., 23, 463 (2002)
  •  
  • 159. De Coppi P, Delo D, Farrugia L, Udompanyanan K, Yoo JJ, Nomi M, Atala A, Soker S, Tissue Eng., 11, 1034 (2005)
  •  
  • 160. Schuch G, Machluf M, Bartsch G, Nomi M, Richard H, Atala A, Soker S, Blood, 100, 4622 (2002)
  •  
  • 161. Ennett AB, Kaigler D, Mooney DJ, J. Biomed. Mater. Res. A, 79, 176 (2006)
  •  
  • 162. Kaigler D, Wang Z, Horger K, Mooney DJ, Krebsbach PH, J. Bone Miner. Res., 21, 735 (2006)
  •  
  • 163. Borselli C, Cezar CA, Shvartsman D, Vandenburgh HH, Mooney DJ, Biomaterials, 32, 8905 (2011)
  •  
  • 164. Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA, Mulligan RC, D’Amore PA, Langer R, Nat. Biotechnol., 23, 879 (2005)
  •  
  • 165. Moon JJ, Saik JE, Poche RA, Leslie-Barbick JE, Lee SH, Smith AA, Dickinson ME, West JL, Biomaterials, 31, 3840 (2010)
  •  
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This Article

  • 2014; 38(2): 113-128

    Published online Mar 25, 2014

  • Received on Dec 16, 2013
  • Accepted on Jan 3, 2014