Article
  • Preparation of Coil-Embolic Material Using Syndiotactic Poly(vinyl alcohol) Gel Spun Fibers
  • Seo YH, Oh YH, Han SS, Joo SW, Khil MS
  • 교대배열 PVA 젤 섬유를 이용한 고분자 색전 코일 제조
  • 서영호, 오태환, 한성수, 주상우, 길명섭
Abstract
The structure, morphology, and physical properties of syndiotatic poly(vinyl alcohol) (s-PVA) gel spun fibers were investigated to prepare polymeric embolization coils. S-PVA was prepared by saponification of the poly(vinyl acetate)/poly(vinyl pivalate)(PVAc/PVPi) copolymer. The viscosity of s-PVA solutions showed shear thinning behavior and the solution formed a homogeneous phase. Based on shear viscosity change with concentration, the optimum dope concentration was selected as 13 wt%, after which s-PVA fibers were spun and the solvent was removed. The fibers were then drawn with a maximum draw ratio of 15. A polymeric embolization coil was made of the s-PVA gel-spun fibers. The fibers were wound densely onto rigid rod and then annealed at different annealing temperatures. The polymeric embolization coil annealed at 200 oC was similar to metallic coils and its shape was maintained well after extension. Overall, gel-spun PVA fibers performed well for the preparation of primary and secondary coils to replace metallic coils.

고분자 색전 코일을 제조하기 위하여 교대배열 PVA(s-PVA) 용액을 제조하고 젤방사 조건의 최적화를 위해 고분자용액의 유변학적 특성을 분석하였다. 현탁중합을 통해 비누화도 99%, 교대배열기 함량 56%인 s-PVA를 제조하였고 고분자 용액의 농도에 따른 점도 변화 측정을 통해 최적의 방사농도를 13 wt%로 선정하였다. S-PVA 젤 섬유의 연신비에 따른 구조, 형태, 인장 특성을 측정하였다. S-PVA 젤 섬유의 연신비가 증가함에 따라 인장강도가 증가하였고, 최대 연신비인 15배 연신하였을 때 인장강도는 580 MPa이었고 절단신도는 연신비가 증가함에 따라 감소하는 경향을 나타냈다. S-PVA 젤 섬유는 연신비에 따라 결정구조가 발달하고 배향도가 증가하는 경향을 나타내었다. 색전 코일 제조 시의 열처리온도에 따른 코일의 형태 안정성을 살펴 본 결과 열처리온도가 높을수록 코일의 형태안정성이 우수하였으며 금속 색전 코일로 제조되는 1차 코일 및 2차 코일 형태를 s-PVA 섬유를 이용해 제조하였고 이를 통해 금속 색전 코일의 고분자로의 대체 가능성을 확인하였다.

Keywords: s-PVA; gel spun fibers; draw ratio; coil; embolization.

References
  • 1. Brown KT, Brody LA, Decorato DR, Getrajdman GI, J. Vasc. Interv. Radiol., 12, 882 (2001)
  •  
  • 2. Ito Y, Hasuda H, Kamitakahara H, Ohtsuki C, Tanihara M, Kang IK, Kwon OH, J. Biosci. Bioeng., 100(1), 43 (2005)
  •  
  • 3. Staudinger H, Frey K, Stark W, Ber. Dtsch. Chem. Ges., 60, 1782 (1927)
  •  
  • 4. Bryant SJ, Nettelman CR, Anseth KS, Biomed. Sci.Instrum., 35, 309 (1999)
  •  
  • 5. Rehman I, Bonfield W, J. Mater. Sci.: Mater. Med., 8, 1 (1999)
  •  
  • 6. Aldenhoff Y, Kruft M, Pijpers P, Veen FH, Bulstra SK, Kuijer R, Koole LH, Biomaterials., 23, 881 (2002)
  •  
  • 7. Dalby MJ, Di Silvio L, Gurav N, Annaz B, Kayser MV, Bonfield W, Tissue Eng., 8, 453 (2002)
  •  
  • 8. Nakano T, Uasa YH, Kanaya Y, Pharm. Res., 16, 1616 (1999)
  •  
  • 9. Kato K, Eika Y, Ikada Y, J. Biomed. Mater. Res., 32, 687 (1996)
  •  
  • 10. Serizawa T, Tateishi T, Akashi M, J. Biomater. Sci. Polym.Ed., 14, 653 (2003)
  •  
  • 11. Schmidt KH, Patel R, Meisel D, J. Am. Chem. Soc., 110, 4882 (1988)
  •  
  • 12. Tamai H, Sakurai H, Suzawa T, Yasuda H, J. Appl. Polym. Sci., 51(7), 1277 (1994)
  •  
  • 13. Luzar A, Chandler D, J. Chem. Phys., 98, 8160 (1993)
  •  
  • 14. Nozakura S, Murahashi MS, J. Polym. Sci., Polym. Chem.Ed., 11, 279 (1973)
  •  
  • 15. Do Ghim H, Kim JP, Kwon IC, Lee CJ, Lee J, Kim SS, Lee SM, Yoon WS, Lyoo WS, J. Appl. Polym. Sci., 87(9), 1519 (2003)
  •  
  • 16. Lyoo WS, Kim JH, Choi JH, Kim BC, Blackwell J, Macromolecules, 34(12), 3982 (2001)
  •  
  • 17. Nakajima N, Kobunshi Kagaku., 11, 142 (1954)
  •  
  • 18. Lyoo WS, Kim BC, Ha WS, Polym. Eng. Sci., 37(7), 1259 (1997)
  •  
  • 19. Lyoo WS, Ha WS, Polymer, 40(2), 497 (1999)
  •  
  • 20. Lyoo WS, Ha WS, Polymer, 37(14), 3121 (1996)
  •  
  • 21. Arruda K, Caniello TM, Queiroz AAA, Mater. Sci. Eng.C., 24, 697 (2004)
  •  
  • 22. Chung YS, Choi CY, Lee KW, Choa YH, Pak PK, J. Korean Fiber Soc., 39, 383 (2002)
  •  
  • 23. Granqvist B, Helmnen A, Vehvilainen M, Aaritalo V, Seppala J, Linden M, Colloid Polym. Sci., 282, 495 (2004)
  •  
  • 24. Lanman TH, Martin NA, Vinters HV, Neuoradiol., 33, 1 (1998)
  •  
  • 25. Tomashefski JF, Cohen AM, Doershuk CF, Human Pathology., 19, 555 (1998)
  •  
  • 26. Lyoo WS, Seo IS, Yeum JH, Yoon WS, Ji BC, Kim BS, Lee SS, Kim BC, J. Appl. Polym. Sci., 86(2), 463 (2002)
  •  
  • 27. Choi JH, Ko SW, Kim BC, Blackwell J, Lyoo WS, Macromolecules, 34(9), 2964 (2001)
  •  
  • 28. Yamamoto T, Seki S, Fukae R, Sangen O, Kamachi M, Polym. J., 22, 567 (1990)
  •  
  • 29. Yamamoto T, Seki S, Hirota M, Kamachi M, Polym. J., 22, 1417 (1987)
  •  
  • 30. Song SI, Seoung YJ, Kim BC, Theories and Applications of Rheology., 7, 135 (2003)
  •  
  • 31. Lee EJ, Kim NH, Kim BC, Korean J. Rheol., 9(3), 118 (1997)
  •  
  • 32. Watase M, Nishinari K, Polym. J., 21, 567 (1989)
  •  
  • 33. Yamaura K, Itoh M, Tanigami T, Matsuzawa S, J. Appl.Polym. Sci., 37, 2709 (1989)
  •  
  • 34. Hanaya M, Osawa I, Watanabe K, J. Therm. Anal.Calorim., 76, 529 (2004)
  •  
  • 35. Hyon SH, Cha WI, Ikada Y, Polym. Bull., 22, 119 (1989)
  •  
  • 36. Packer KJ, Tomlinson DJ, Trans. Faraday Soc., 67, 1302 (1971)
  •  
  • 37. Safford GT, Schaffer PC, Leung P, Doebbler GF, Brady GW, Lyden EFX, J. Chem. Phys., 50, 3140 (1969)
  •  
  • 38. Prokopova E, Stern P, Quadrat O, Colloid Polym. Sci., 263, 899 (1985)
  •  
  • 39. Cacace MG, Landau EM, Ramsden J, J. Rev. Biophys., 30, 241 (1997)
  •  
  • 40. Watase M, Nishinari K, Polym. J., 21, 567 (1989)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2013; 37(4): 486-493

    Published online Jul 25, 2013

  • Received on Feb 6, 2013
  • Accepted on Apr 29, 2013