Article
  • Preparation of PNIPAM Hydrogel Containing Lipoic Acid
  • Yoon H, Lee J
  • 리포익산을 함유한 PNIPAM 하이드로젤의 제조
  • 윤혜리, 이종휘
Abstract
Poly(N-isopropylacrylamide) (PNIPAM) hydrogel has been studied as an important drug delivery system due to its volume transition or temperature-responsive swelling properties, whose phase separation temperature is similar to the body temperature. However, because of hydrophilic PNIPAM, hydrophobic drugs are difficult to be uniformly loaded in the networks. Antioxidant alpha-lipoic acid (LA) can be prepared as a polymer(polylipoic acid, PLA) by ring opening polymerization, which is hardly developed as a material due to its low molecular weight and easy depolymerization. To overcome this limitation, a hydrophobic active ingredient, LA was reacted with NIPAM into stable hydrogels. Simple thermal radical reaction successfully resulted in a hydrogel (PNIPAM/PLA), which was confirmed by DSC, FTIR, and Raman spectroscopy. The PNIPAM/PLA showed temperature-responsive properties, and their volume swelling decreased with an increase in lipoic acid content. These hydrogels can carry hydrophobic drugs with PNIPAM and the hydrogels could be useful as final drug delivery systems having lipoic acid as an antioxidant.

Poly(N-isopropylacrylamide)(PNIPAM)는 체온과 비슷한 온도에서 부피상 변화 혹은 온도 감응성 팽윤 거동의 특성을 보여 약물전달시스템에서 중요하게 연구되고 있다. 그러나 PNIPAM의 친수성 특징 때문에 소수성 약물을 그 네트워크 안에 고르게 넣기는 쉽지 않다. 항산화제인 알파 리포익산은 개환중합으로 고분자화(polylipoic acid, PLA) 될 수는 있으나, 분자량이 낮고 분해되기 쉬워 고분자 재료로 사용되기에는 어려움이 많다. 이러한 결점들을 극복하기 위해 소수성 활성성분인 알파 리포익산을 NIPAM과 반응시켜 안정적인 하이드로젤을 만들었다. 단순한 혼합과 가열에 의한 라디칼 반응으로 하이드로젤(PNIPAM/PLA)이 성공적으로 만들어졌고, 이를 DSC, FTIR, Raman spectroscopy를 통해서 확인하였다. PNIPAM/PLA는 온도 감응성 특성을 보여주며, 리포익산의 함량이 증가 할수록 부피팽창 정도는 감소하였다. 이러한 하이드로젤을 사용하여 PNIPAM에 소수성 약물을 쉽게 담지할 수 있고 리포익산은 항산화제로 효과가 있어, 본 하이드로젤은 최종 약물전달체로서도 유용하다.

Keywords: alpha-lipoic acid; poly(N-isopropylacrylamide); hydrogel; temperature-responsive; drug delivery.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2012; 36(4): 455-460

    Published online Jul 25, 2012

  • Received on Dec 27, 2011
  • Accepted on Feb 20, 2012