Article
  • Drug Delivery System Using Electrospun Nanofiber Mats
  • Yoon H, Park YK, Kim GH
  • 전기방사된 나노파이버 매트를 이용한 약물전달시스템에 관한 연구
  • 윤현, 박윤경, 김근형
Abstract
The nanofibers fabricated by using an electrohydrodynamic process has been used as various applications, such as nano-device, filtering system, protective clothes, wound dressing, and drug delivery system (DDS). Of these applications, the DDS should be needed to minimize side effects of drugs, maximize the properties of medicine, and efficiently deliver the required amount of drugs to the diseased area. In this paper, by using the electrospinning process, which is one of electrohydrodynamic processes, two different types, polycarprolactone and poly(ethylene oxide)/Rhodamine B, of electrospun mats were fabricated layer by layer and the release behavior of Rhodamine B was characterized with time. In addition, to show the feasibility of DDS of this type, we tested release behavior of a peptide of the nanofiber system, a PCL/(Peptide+PEO)/PCL nanofiber mat. The released peptide did not loss biological activities. From these results, we believe that the layered nanofiber mat as a DDS has enough function of a new drug delivery system.

전기방사 공정을 이용하여 제조된 나노파이버는 나노 소자, 필터, 방호복, 항균성 드레싱 및 약물전달 등 다양한 분야에서 이용되고 있다. 약물전달시스템(drug delivery system, DDS)은 기존 의약품의 부작용을 최소화하며 그 효능 및 효과를 극대화할 수 있어야 하고 필요한 양의 약물을 원하는 환부에 효율적으로 전달할 수 있어야 한다. 본 연구에서는 전기유체역학공정의 하나인 전기방사공정을 이용하여, poly(ε-carprolactone)(PCL), poly(ethylene oxide(PEO)를 나노파이버 매트로 만들었으며, 고분자와 동시 방사된 Rhodamine B의 방출량을 측정하였다. PCL/Rhodamine B/PEO/PCL 나노파이버 매트는 전기방사 시간을 통한 두께 조절을 통하여 약물전달 거동이 조절될 수 있음을 확인하였으며, 실제 peptide를 PEO와 동시 전기방사시켜 얻어진 나노파이버 peptide가 방출되는 거동을 확인하였다. PCL/peptide/PEO/PCL시스템에서 방출된 peptide는 약물방출 시험 후에도 약물로서의 활성도를 잃지 않았으며, 이러한 나노파이버를 이용한 peptide 방출메커니즘은 새로운 약물전달시스템으로 적용 및 응용될 수 있을 것으로 예상된다.

Keywords: drug delivery system; nanofiber; electrospinning; PCL; PEO.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2009; 33(3): 219-223

    Published online May 25, 2009

  • Received on Dec 5, 2008
  • Accepted on Jan 28, 2009