Article
  • Norfloxacin-Incorporated Polymeric Micelle Composed of Poly(ε-caprolactone)/Poly(ethylene glycol) Diblock Copolymer
  • Jeong YI, Jang MK, Nah JW
  • Norfloxacin이 담지된 Poly(ε-caprolactone)/Poly(ethylene glycol) 이중블록공중합체 미셀의 제조
  • 정영일, 장미경, 나재운
Abstract
We prepared norfloxacin (NFX)-incorporated polymeric micelle using poly(ε-caprolactone)/ poly(ethylene glycol) (PCL/PEG, CE) diblock copolymers. Particle size was from 60 to 200 nm according to the PCL block length. Their critical association concentration (CAC) was decreased according to the increase of PCL block length. 1H-NMR study showed core-shell type micelle structures of CE diblock copolymers in the aqueous environment. Drug release from polymeric micelle was continued over 2 days. Duration of drug release was varied according to the PCL block length and drug contents. At antimicrobial activity test, polymeric micelle showed almost similar cytotoxicity compared to NFX itself.

이 연구에서 norfloxacin(NFX)이 담지된 poly(ε-caprolactone)/poly(ethylene glycol)(PCL/PEG, abbreviated as CE) 이중블록공중합체로 구성된 고분자 미셀을 제조하였다. 입자크기는 PCL블록길이에 따라 60∼200nm사이였다. 임계회합농도는 소수성 PCL 블록길이가 증가함에 따라 감소하는 경향을 보였다. 1H-NMR 연구에서 PCL 블록은 내핵, PEG는 외피를 형성한 미셀구조로 형성되었음을 확인하였다. 약물의 방출은 약 2일간 지속되었으며 PCL 블록길이와 약물함량이 증가함에 따라 감소하는 경향을 보였다. 항미생물 성능 실험에서 고분자 미셀은 기존의 NFX와 비슷한 독성을 보였다.

Keywords: polymeric micelle; norfloxacin; biodegradable polymer; antimicrobial agent; diblock copolymer.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2009; 33(2): 137-143

    Published online Mar 25, 2009

  • Received on Oct 15, 2008
  • Accepted on Nov 24, 2008