Article
  • Loading Behavior of pH-Responsive P(MAA-co-EGMA) Hydrogel Microparticles for Intelligent Drug Delivery Applications
  • Shin Y, Kim KS, Kim B
  • 지능형 약물전달시스템을 위한 pH 감응형 P(MAA-co-EGMA) 수화젤 미세입자의 탑재거동
  • 신영찬, 김규식, 김범상
Abstract
pH-responsive P(MAA-co-EGMA) hydrogel microparticles were synthesized via dispersion photopolymerization and the feasibility of the particles as the cosmetic formulation was investigated. Rh-B and the functional materials for the cosmetic application such as ascorbic acid, adenosine, EGCG, and arbutin were loaded in the P(MAA-co-EGMA) hydrogel microparticles in order to examine the interaction between the hydrogel and the loaded materials. In the loading experiments, Rh-B showed the highest loading efficiency to the P(MAA-co-EGMA) hydrogels due to the electrostatic attraction between the negative charge of the hydrogels and the positive charge of Rh-B at the ionized states. However, the functional materials showed relatively low loading efficiencies because of the electrostatic repulsions between the negative charges of both the hydrogels and the materials at the ionized states. In addition, P(MAA-co-EGMA) hydrogel microparticles showed pH-responsive release behavior of Rh-B according to the external pH changes.

pH 감응형 P(MAA-co-EGMA) 수화젤을 분산 광중합을 이용하여 마이크로 크기의 미세입자로 합성하고 화장품 제형으로서의 응용 가능성을 평가하기 위하여 모델 탑재물질인 Rh-B와 화장품 분야에서 기능성 물질로 사용되는 ascorbic acid, adenosine, EGCG, arbutin을 이용하여 탑재 및 방출 거동을 조사하였다. Rh-B 탑재의 경우, pH 6.5인 수용액에서 이온화에 의한 P(MAA-co-EGMA) 수화젤의 음전하와 Rh-B의 양전하 사이의 정전기적 인력으로 인하여 가장 높은 탑재효율을 나타내었다. 그러나 화장품 기능성 물질들의 경우, pH 6.5 수용액에서 이온화된 P(MAA-co-EGMA) 수화젤의 음전하와 기능성 물질들이 나타내는 음전하 사이의 정전기적 반발력 때문에 상대적으로 낮은 탑재효율을 나타내었다. Rh-B를 사용한 방출실험 결과, P(MAA-co-EGMA) 수화젤 미세입자는 높은 pH에서는 다량의 Rh-B를 그리고 낮은 pH에서는 소량의 Rh-B를 방출하는 pH 감응성 방출거동을 나타내었다.

Keywords: pH-responsive; hydrogel microparticles; pKa of hydrogel; cosmetic materials; loading efficiency

References
  • 1. Kanjickal D, Lopina S, Evancho-Chapman MM, Schmidt S, Donovan D, Springhetti S, J. Biomed. Mater. Res., 68A, 489 (2003)
  •  
  • 2. Heller J, J. Control. Release(125), 8, 111
  •  
  • 3. Creasy GW, Jaffe ME, Adv. Drug Deliv. Rev., 6, 51 (1991)
  •  
  • 4. Kwon IC, J. Korean Fiber Society, 33, 912 (1996)
  •  
  • 5. Khang G, Kim MS, Cho SH, Lee HB, Chang JH, Kim KJ, Polym. Sci. Technol., 14(4), 431 (2003)
  •  
  • 6. Qiu Y, Park KN, Adv. Drug Deliv. Rev., 53, 321 (2001)
  •  
  • 7. Kim B, News Inf. Chem. Eng., 24(6), 612 (2006)
  •  
  • 8. Lee YW, Hwang YI, Lee SC, Koeran J. Food Sci. Technol., 31, 280 (1999)
  •  
  • 9. Muth GW, Ortoleva-Donnelly L, Strobe SA, Science, 289, 947 (2000)
  •  
  • 10. Hagerman AE, Dean RT, Davies MJ, Arch. Biochem. Biophys., 414, 115 (203)
  •  
  • 11. Bian SJ, Choi MK, Lin HX, Chung SJ, Shim CK, Kim DD, Zheng JM, J. Kor. Pharm.Sci., 36, 299 (2006)
  •  
  • 12. Kim B, Peppas NA, Int. J. Pharm., 266, 29 (2003)
  •  
  • 13. Kim B, Peppas NA, Polymer, 44(13), 3701 (2003)
  •  
  • 14. Kim B, Peppas NA, Macromolecules, 35(25), 9545 (2002)
  •  
  • 15. Beyer P, Nordmeier E, Eur. Polym. J., 35, 1351 (1999)
  •  
  • 16. Kim KC, Lee SJ, Yakhak Hoehi, 33, 372 (1989)
  •  
  • 17. Mchedlov-Petrossyan NO, Vodolazkaya NA, Doroshenko AO, J. Fluorescence, 13, 235 (2003)
  •  
  • 18. Merck 13th Edition, 8266.
  •  
  • 19. Holder AA, Brown1 RFG, Marshall1 SC, Payne VCR, Cozier MD, Alleyne WA, Bovell CO, Transit. Met. Chem., 25, 605 (2000)
  •  
  • 20. Merck 13th Edition, 837.
  •  
  • 21. Merck 13th Edition, 154.
  •  
  • 22. Merck 13th Edition, 3557.
  •  
  • 23. Merck 13th Edition, 778.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2008; 32(5): 421-426

    Published online Sep 25, 2008

  • Received on Apr 2, 2008
  • Accepted on Jun 9, 2008