Article
  • Characterization and Biocompatibility with Dispersed Solution of PLA-POE-PLA Block Copolymer
  • Lee CW, Kim H, Song KH, Moon SI
  • PLA-POE-PLA 블록공중합체 분산액에 의한 생체적합성의 평가 및 특성
  • 이찬우, 김 홍, 송경헌, 문성일
Abstract
PLLA-POE-PLLA block copolymers were prepared using PLLA and POE with different compositions. Copolymers were obtained in high yield and the polydispersity of the copolymers was very narrow. A dispersed solution of 0.1 g/mL of PLLA-POE-PLLA copolymer was mixed with a dispersed solution of 0.1 g/mL of PDLA-POE-PDLA copolymer. Gel formation was observed from the mixed product obtained at the human body temperature of 37 ℃. The mixed product comprising PDLA-POE-PDLA and PLLA-POE-PLLA was found to have higher cloud points than that of PLLA-POE-PLLA copolymer. The cloud points decreased with increasing the concentration of the mixed copolymer dispersed solution.

조성비가 서로 다른 각종의 PLLA-POE-PLLA와 PDLA-POE-PDLA블록공중합체의 합성을 실시하여 모든 공중합체를 고수율이며 다분산도가 현저하게 작은 생성물을 얻었으며, 그 결과 체온 부근인 37 ℃에서는 0.1 g/mL PLLA-POE-PLLA 분산액과 0.1 g/mL PDLA-POE-PDLA의 혼합분산액에서 겔의 형성이 관찰되었다. 또한 PLLA-POE-PLLA분산액과 비교하여 PLLA-POE-PLLA분산액과 PDLA-POE-PDLA분산액을 혼합한 분산액의 흐림점이 높아지는 것을 확인하였으며 고농도일수록 흐림점이 낮아지는 현상도 확인되었다.

Keywords: block copolymer; polydispersity; dispersed solution; cloud point

References
  • 1. Lee CW, Kimura Y, Bull. Chem. Soc. Jpn., 69, 1787 (1996)
  •  
  • 2. Casey DJ, Huffman KR(Am. Cyanamid Co.) US Patent 4438253 (1948)
  •  
  • 3. Vitalis EA, Chem. Abstr.(Am. cyanamid Co.), US Patent 2917410, 54, 7173d (1960)
  •  
  • 4. Tsuji H, Ikada Y, Macromolecules, 25, 5719 (1992)
  •  
  • 5. Tsuji H, Ikada Y, Macromol. Phys., 197, 3483 (1996)
  •  
  • 6. Ikada Y, Jamshidi K, Tsuji H, Hyon SH, Macromolecules, 20, 904 (1987)
  •  
  • 7. Tsuji H, Ikada Y, Macromolecules, 26, 6918 (1993)
  •  
  • 8. Tsuji H, Horii F, Hyon SH, Ikada Y, Macromolecules, 24, 2719 (1991)
  •  
  • 9. Tsuji H, Hyon SH, Ikada Y, Macromolecules, 24, 5651 (1991)
  •  
  • 10. Tsuji H, Hyon SH, Ikada Y, Macromolecules, 24, 5657 (1991)
  •  
  • 11. Tsuji H, Hyon SH, Ikada Y, Macromolencules, 25, 2940 (1992)
  •  
  • 12. Tsuji H, Horii F, Nakagawa M, Ikada Y, Odani H, Kitamura R, Macromolecules, 25, 2940 (1992)
  •  
  • 13. Tsuji H, Ikada Y, Hyon SH, Kimura Y, Kitao T, J. Appl. Polym. Sci., 51(2), 337 (1994)
  •  
  • 14. Shiraki K, Tsuji H, Hyon SH, Ikada Y, Nakamura T, Shimiizu Y, Polym. Prepr, Jpn., 39, 584 (1990)
  •  
  • 15. Kim BS, Hrkach JS, Langer R, Biomaterials, 21, 259 (2000)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2002; 26(2): 174-178

    Published online Mar 25, 2002

  • Received on Aug 8, 2001
  • Accepted on Feb 11, 2002