Article
  • Mixture Density Measurement of Biodegradable Poly(lactide-co-glycolide) Copolymer in Supercritical Solvents
  • Byun HS
  • 초임계 용매내에서 생분해성 Poly(lactide-co-glycolide)공중합체의 혼합물 밀도 측정
  • 변헌수
Abstract
The mixture density dara for poly(lactide-co-glycolide) [PLGA] with supercritical CO2. CHF3 and CHCIF2 were obtained in the temperature range of 27 to 100℃ and at pressures as high as 3000bar(PLGAx, where the molar concentration of glycolide in the backbone, x, range from 0 to 50mol%). The PLA-CO2, PLA-CHF 3, and PLA-CHClF 2 systems dissolve in the pressure less than 1430, below 700, and below 100bar, respectively. The mixture density shows from 1.084 to 1.334g/cm3 at temperatures from 27 to 93℃. The PLGA15-CO2 mixture dissolves at pressures of below 1900 bar and the mixture density is in the range of 1.158 to 1.247g/cm3 at temperatures between 37 and 92℃. The solubilities of the PLGA25 for CO2, CHF3, and CHCIF2 are shown to pressure as high as 2390,1470, and 118bar, respectively, and the mixture density exhibits from 1.154 to 1.535g/cm3 at temperatures from 29 to 81 ℃. The PLGA50-CO2 system does not dissolve at 240℃ and 3000bar while the PLGA50-CHCIF2 does easily at 50℃ and 100 bar. The mixture density for the PLGA-CHCIF2 system increases even at low pressures as the glycolide molar concentration increases.

본 연구는 초임계 용매인 CO2, CHF3 및 CHCIF2내에서 poly(lactic-co-glycolide)[PLGA] 용액과의 혼합물 밀도를 측정하였다. 초임계 용매와 poly(lactic acid) [PLA] 및 PLGA간의 혼합물 밀도는 온도 27∼100℃와 압력 3000bar까지 실험하여 나타내었다. [PLGAx의 X는 0∼50mol% 범위에 대한 glycolide의 몰농도이다]. PLA-CO2 혼합물은 약 1430 bar 이내에서, PLA-CHF3계는 700 bar이하에서, PLA-CHCIF3계는 100bar이하에서 각각 용해되었다 이때 온도범위는 27∼93℃이며, 혼합물 밀도는 1.084∼1.334g/cm3 범위에서 나타났다. PLGA15 공중합체-CO2 혼합물은 약 1900 bar 이하에서 용해되었으며, 이때 혼합물 밀도는 37∼92℃에서 1.158∼1.247g/cm3으로 나타났다. PLGA25공중합체-CO2계는 약 2390 bar이하에서, PLGA25-CIF3계에 대해서는 1470 bar이하에서, PLGA25-CIF3계에 대해서는 118 bar 이하에서 각각 용해되었으며, 혼합물 밀도는 29∼81℃사이에서 1.154∼1.535g/cm3로 나타났다. PLGA50-CO2계는 240℃, 3000 bar내에서는 용해되지 않았으며, 반면 PLGA50과 CHCIF2계는 glycolide농도가 증가함에 따라 혼합물 밀도가 증가하였다.

Keywords: poly(lactide-co-glycolide) copolymer; mixture density; supercritical solvents

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  • Polymer(Korea) 폴리머
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This Article

  • 2000; 24(4): 505-512

    Published online Jul 25, 2000