Article
  • A Study on the Degradation of Chitosan-g-Poly(vinyl alcohol) Copolymer Membranes
  • Kweon DK, Kang DW, Chung NJ
  • Chitosan-g-Poly(vinyl alcohol) 공중합체막의 분해에 관한 연구
  • 권동건, 강두환, 정낙진
Abstract
Chitosan-g-PVA copolymer was prepared by grafting poly(vinyl alcohol) (PVA), a water soluble polymer, onto chitosan which has an excellent biocompatibility and biodegradation. Its biodegradation, tensile strength and critical surface tension were studied according to various conditions. The biogradable characteristics of chitosan-g-PVA copolymer were studied using the lysozyme as a degrading enzyme under pH 1.2, 6.7, 7.4, and 8.2. Chitosan-g-PVA copolymer rapidly degraded at pH 6.7, 7.4 and 8.2 within the first week, and the tensile strength decreased. Especially, the most biogradable PH range for chitosan-g-PVA copolymer was 6.7 ~ 7.4. While critical surface tension of chitosan was about 32 dyne/cm, that of chitosan-g-PVA copolymer was a little decreased about 26 ~ 29 dyne/cm.

생체적합성과 생분해성이 뛰어난 키토산에 수용성 고분자인 폴리비닐알콜(PVA)을 그라프트시켜 chitosan-g-PVA 공중합체를 합성한 후 여러 조건 변화에 따른 분해도와 기계적 강도 및 임계표면에너지 변화를 살펴보았다. 분해효소로 lysozyme을 사용하여 chitosan-g-PVA 공중합체막의 분해도를 살펴본 결과, pH 6.7, 7.4, 8.2에서는 초기 1주일내에 급격하게 분해가 일어나 인장강도가 크게 감소하며, pH 6.7과 7.4에서 분해도가 가장 우수함을 알 수 있었다. Chitosan-g-PVA 공중합체막의 임계표면에너지 변화를 측정한 결과, 키토산막의 경우 임계표면에너지는 32 dyne/cm인 반면에 chitosan-g-PVA 공중합체막의 경우 26~29 dyne/cm으로서 키토산에 비해 임계표면에너지가 낮아지게 됨을 알 수 있었다.

Keywords: chitosan-g-poly(vinyl alcohol) copolymer; biodegradation; tensile strength; contact angle; critical surface tension

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1998; 22(5): 786-792

    Published online Sep 25, 1998