Article
  • Characterization of Bioreducible and Cathepsin B Responsive PAMAM Dendrimer Derivative for Gene Delivery System
  • Seulgi Lee# , Jeil Lee# , Le Thi Thuy, and Joon Sig Choi

  • Department of Biochemistry, Chungnam National University, 99 Daehak-ro, Daejeon 34134, Korea

  • 생체환원성 및 카텝신 효소 감응성 PAMAM 덴드리머 유도체의 유전자 전달체 특성 연구
  • 이슬기# · 이제일# · 레티쑤이 · 최준식

  • 충남대학교 자연과학대학 생화학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Baden, L. R.; El Sahly, H. M.; Essink, B.; Kotloff, K.; Frey, S.; Novak, R.; Diemert, D.; Spector, S. A.; Rouphael, N.; Creech, C. B.; McGettigan, J.; Khetan, S.; Segall, N.; Solis, J.; Brosz, A.; Fierro, C.; Schwartz, H.; Neuzil, K.; Corey, L.; Gilbert, P.; Janes, H.; Follmann, D.; Marovich, M.; Mascola, J.; Polakowski, L.; Ledgerwood, J.; Graham, B. S.; Bennett, H.; Pajon, R.; Knightly, C.; Leav, B.; Deng, W.; Zhou, H.; Han, S.; Ivarsson, M.; Miller, J.; Zaks, T.; Group, C. S., Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N. Engl. J. Med, 2021, 384, 403-416.
  •  
  • 2. Zhang, P.; Wagner, E. History of Polymeric Gene Delivery Systems. Top Curr. Chem. 2017, 375, 26.
  •  
  • 3. Mukalel, A. J.; Riley, R. S.; Zhang, R.; Mitchell, M. J. Nanoparticles for Nucleic Acid Delivery: Applications in Cancer Immunotherapy. Cancer Lett. 2019, 458, 102-112.
  •  
  • 4. Ullah, I.; Muhammad, K.; Akpanyung, M.; Nejjari, A.; Neve, A. L.; Guo, J.; Feng, Y.; Shi, C. Bioreducible, Hydrolytically Degradable and Targeting Polymers for Gene Delivery. J. Mater. Chem. B, 2017, 5, 3253-3276.
  •  
  • 5. Peng, L.; Wagner, E. Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions. Biomacromolecules 2019, 20, 3613-3626.
  •  
  • 6. Thomas, T. J.; Tajmir-Riahi, H. A.; Pillai, C. K. S. Biodegradable Polymers for Gene Delivery. Molecules 2019, 24, 3744.
  •  
  • 7. Riley, M. K.; Vermerris, W. Recent Advances in Nanomaterials for Gene Delivery-A Review. Nanomaterials 2017, 7, 94.
  •  
  • 8. Nie, X.; Zhang, Z.; Wang, C. H.; Fan, Y. S.; Meng, Q. Y.; You, Y. Z. Interactions in DNA Condensation: An Important Factor for Improving the Efficacy of Gene Transfection. Bioconjug Chem. 2019, 30, 284-292.
  •  
  • 9. Peeler, D. J.; Sellers, D. L.; Pun, S. H. pH-Sensitive Polymers as Dynamic Mediators of Barriers to Nucleic Acid Delivery. Bioconjug Chem. 2019, 30, 350-365.
  •  
  • 10. Vaidyanathan, S.; Chen, J.; Orr, B. G.; Banaszak Holl, M. M. Cationic Polymer Intercalation into the Lipid Membrane Enables Intact Polyplex DNA Escape from Endosomes for Gene Delivery. Mol. Pharm. 2016, 13, 1967-1978.
  •  
  • 11. Son, S. J.; Yu, G. S.; Choe, Y. H.; Kim, Y.-J.; Lee, E.; Park, J.-S.; Choi, J. S. PAMAM Dendrimers Conjugated with L-arginine and γ-aminobutyric Acid as Novel Polymeric Gene Delivery Carriers. Bulletin Korean Chem. Society 2013, 34, 579-584.
  •  
  • 12. Yang, B. S.; Mallick, S.; Kwon, Y. E.; Kim, Y. J.; Kim, G. H.; Choi, J. S. PAMAM Dendrimer Conjugated with Cell-penetrating Peptide-derived Oligopeptides for Enhanced Cell Uptake and Gene Delivery. Bulletin Korean Chem. Society 2015, 36, 2477-2483.
  •  
  • 13. Yu, G. S.; Bae, Y. M.; Choi, H.; Kong, B.; Choi, I. S.; Choi, J. S. Synthesis of PAMAM Dendrimer Derivatives with Enhanced Buffering Capacity and Remarkable Gene Transfection Efficiency. Bioconjug Chem. 2011, 22, 1046-1055.
  •  
  • 14. Gu, J.; Chen, X.; Ren, X.; Zhang, X.; Fang, X.; Sha, X. CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery. Bioconjug Chem. 2016, 27, 1723-1736.
  •  
  • 15. Hu, H.; Wang, H.; Liang, S.; Li, X.; Wang, D. Synthesis and Characterization of a PAMAM Dendrimer Nanocarrier Functionalized by HA for Targeted Gene Delivery Systems and Evaluation In Vitro. J. Biomater Sci. Polym. Ed., 2021, 32, 205-228.
  •  
  • 16. Erel-Akbaba, G.; Carvalho, L. A.; Tian, T.; Zinter, M.; Akbaba, H.; Obeid, P. J.; Chiocca, E. A.; Weissleder, R.; Kantarci, A. G.; Tannous, B. A. Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy. ACS Nano, 2019, 13, 4028-4040.
  •  
  • 17. Lee, J.; Kwon, Y. E.; Kim, Y.; Choi, J. S. Enhanced Transfection Efficiency of Low Generation PAMAM Dendrimer Conjugated with the Nuclear Localization Signal Peptide Derived from Herpesviridae. J. Biomater Sci. Polym. Ed., 2021, 32, 22-41.
  •  
  • 18. Smith, R. J.; Gorman, C.; Menegatti, S. Synthesis, Structure, and Function of Internally Functionalized Dendrimers. J. Polym. Sci. 2021, 59, 10-28.
  •  
  • 19. Song, S. J.; Choi, J. S. Enzyme-Responsive Amphiphilic Peptide Nanoparticles for Biocompatible and Efficient Drug Delivery. Pharmaceutics 2022, 14, 143.
  •  
  • 20. Lee, S.; Son, S. J.; Song, S. J.; Ha, T. H.; Choi, J. S. Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene Delivery. Polymers 2017, 9, 224.
  •  
  • 21. Gondi, C. S.; Rao, J. S. Cathepsin B as a Cancer Target. Expert Opinion on Therapeutic Targets 2013, 17, 281-291.
  •  
  • 22. Terasawa, Y.; Hotani, T.; Katayama, Y.; Tachibana, M.; Mizuguchi, H.; Sakurai, F. Activity Levels of Cathepsins B and L in Tumor Cells are a Biomarker for Efficacy of Reovirus-mediated Tumor Cell Killing. Cancer Gene Ther 2015, 22, 188-197.
  •  
  • 23. Isidro-Llobet, A.; Alvarez, M.; Albericio, F. Amino Acid-protecting Groups. Chem Rev 2009, 109, 2455-2504.
  •  
  • 24. Park, H. W.; Yu, G. S.; Song, S. J.; Choi, J. S. Conjugation of Peptide to Cystamine Core Polyamidoamine with γ-aminobutyric Acid for Gene Delivery. Polymer-Korea 2015, 39, 727-732.
  •  
  • 25. Lee, S.; Song, S. J.; Lee, J.; Ha, T. H.; Choi, J. S. Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells. Pharmaceutics 2020, 12, 876.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2023; 47(3): 340-347

    Published online May 25, 2023

  • 10.7317/pk.2023.47.3.340
  • Received on Jan 10, 2023
  • Revised on Feb 21, 2023
  • Accepted on Mar 13, 2023

Correspondence to

  • Joon Sig Choi
  • Department of Biochemistry, Chungnam National University, 99 Daehak-ro, Daejeon 34134, Korea

  • E-mail: joonsig@cnu.ac.kr