Article
  • Polymer-based Sustained Release Tablets of Vitamin C Using Hydroxypropyl Methylcellulose and Ethylcellulose and Their Dissolution Tolerances

  • Hyeon Kyun Kim# , Gi Hyeong Sin# , Yoon Tae Goo, Chang Hyun Kim, Suk Hyung Kwon*, Jae Chul Jung*, and Young Wook Choi†

  • College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul 06974, Korea
    *Novarex Co., Ltd., Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk-do, Korea

  • 히드록시프로필 메틸셀룰로오스와 에틸셀룰로오스를 이용한 고분자 기반 서방형 비타민 C 정제 설계 및 용출 규격 설정

  • 김현균# ·신기형# ·구윤태 ·김창현 ·권석형* ·정재철* ·최영욱†

  • 중앙대학교 약학대학, *주식회사 노바렉스

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Devaki, S. J.; Raveendran, R. L. Vitamin C: Sources, Functions, Sensing and Analysis [Online]; IntechOpen: London, 2017; pp 1-18. https://www.intechopen.com/chapters/56440 (accessed Sep 28, 2021).
  •  
  • 2. Olmedo, J. M.; Yiannias, J. A.; Windgassen, E. B.; Gornet, M. K. Scurvy: A Disease Almost Forgotten. Int. J. Dermatol. 2006, 45, 909-913.
  •  
  • 3. Gordon, B. L.; Galati, J.; Yang, S.; Katz, P. O.; Scherl, E. J. Vitamin C Deficiency: An Under-Recognized Condition in Crohn's Disease. ACG Case Rep. J. 2020, 7, e00424.
  •  
  • 4. McGregor, G. P.; Biesalski, H. K. Rationale and Impact of Vitamin C in Clinical Nutrition. Curr. Opin. Clin. Nutr. Metab. Care 2006, 9, 697-703.
  •  
  • 5. Choi, K. M.; Hoon, K. M.; Won, H. T.; Kim, J. D.; Kim, M. Y.; Jung, Y. R.; Shin, H. S. Comparative Bioavailability of Synthetic Vitamin C and Nutra-C (Calcium Ascorbate) in Korean Healthy Volunteers. Anal. Sci. Technol. 2016, 29, 162-169.
  •  
  • 6. Hill, A.; Wendt, S.; Benstoem, C.; Neubauer, C.; Meybohm, P.; Langlois, P.; Adhikari, N. K. J.; Heyland, D. K.; Stoppe, C. Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach. Nutrients 2018, 10, 974.
  •  
  • 7. Cha, J. H.; Hong, J. K.; Lee, S. W.; Cha, J. U.; Ko, W. H.; Baek, H. H.; Park, H. J. Dissolution Profile Analysis of Hydroxypropyl Methylcellulose-based Vitamin C Tablets. Korean J. Food Sci. Technol. 2012, 44, 274-279.
  •  
  • 8. Perrie, Y.; Rades, T. Controlled-Release Dosage Forms. FASTtrack Pharmaceutics: Drug Delivery and Targeting; Pharmaceutical Press: London, 2012; pp 119-139.
  •  
  • 9. Ray, B.; Gupta, M. M. Formulation and Evaluation of Once Daily Sustained Release Matrix Tablet of Verapamil Hydrochloride. J. Drug Delivery Ther. 2013, 3, 55-58.
  •  
  • 10. Jaimini, M.; Kothari, A. Sustained Release Matrix Type Drug Delivery System: A Review. J. Drug Delivery Ther. 2012, 2, 142-148.
  •  
  • 11. Chae, Y. B.; Kim, S. Y.; Kang, C. Y.; Park, J. B. Effect of Hydrophilic and Hydrophobic Polymers on the Sustained-release Sarpogrelate HCl from Matrix Tablets. Yakhak Hoeji 2020, 64, 446-453.
  •  
  • 12. Shin, T. H.; Ho, M. J.; Kim, S. R.; Im, S. H.; Kim, C. H.; Lee, S.; Kang, M. J.; Choi, Y. W. Formulation and In Vivo Pharmacokinetic Evaluation of Ethyl Cellulose-coated Sustained Release Multiple-unit System of Tacrolimus. Int. J. Biol. Macromol. 2018, 109, 544-550.
  •  
  • 13. Yamada, T.; Onishi, H.; Machida, Y. In Vitro and In Vivo Evaluation of Sustained Release Chitosan-coated Ketoprofen Microparticles. Yakugaku Zasshi 2001, 121, 239-245.
  •  
  • 14. Wadher, K. J.; Kakde, R. B.; Umekar, M. J. Formulation of Sustained Release Metformin Hydrochloride Matrix Tablets: Influence of Hydrophilic Polymers on the Release Rate and In Vitro Evaluation. Int. J. Res. Contr. Rel. 2011, 1, 9-16.
  •  
  • 15. Mughal, M. A.; Iqbal, Z.; Neau, S. H. Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride. AAPS PharmSciTech 2011, 12, 77-87.
  •  
  • 16. Siepmann, F.; Hoffmann, A.; Leclercq, B.; Carlin, B.; Siepmann, J. How to Adjust Desired Drug Release Patterns from Ethylcellulose-coated Dosage Forms. J. Controlled Release 2007, 119, 182-189.
  •  
  • 17. Siepmann, F.; Siepmann, J.; Walther, M.; MacRae, R. J.; Bodmeier, R. Polymer Blends for Controlled Release Coatings. J. Controlled Release 2008, 125, 1-15.
  •  
  • 18. Nerdy, N. Determination of vitamin C in various colours of bell pepper (Capsicum annuum L.) by Titration Method. ALCHEMY Jurnal Penelitian Kimia 2018, 14, 164-177.
  •  
  • 19. Fontannaz, P.; Kilinç, T.; Heudi, O. HPLC-UV Determination of Total Vitamin C in a Wide Range of Fortified Food Products. Food Chem. 2006, 94, 626-631.
  •  
  • 20. Xie, F.; Ji, S.; Cheng, Z. In Vitro Dissolution Similarity Factor (f2) and In Vivo Bioequivalence Criteria, How and When Do They Match? Using a BCS Class II Drug as a Simulation Example. Eur. J. Pharm. Sci. 2015, 66, 163-172.
  •  
  • 21. Shoaib, M. H.; Tazeen, J.; Merchant, H. A.; Yousuf, R. I. Evaluation of Drug Release Kinetics from Ibuprofen Matrix Tablets Using HPMC. Pak. J. Pharm. Sci. 2006, 19, 119-124.
  •  
  • 22. Padayatty, S. J.; Levine, M. New Insights into the Physiology and Pharmacology of Vitamin C. Can. Med. Assoc. J. 2001, 164, 353-355.
  •  
  • 23. Wechtersbach, L.; Cigić, B. Reduction of Dehydroascorbic Acid at Low pH. J. Biochem. Biophys. Methods. 2007,70,767-772.
  •  
  • 24. Klimczak, I.; Gliszczyńska-Świgło, A. Comparison of UPLC and HPLC Methods for Determination of Vitamin C. Food Chem. 2015,175, 100-105.
  •  
  • 25. Sung, K. C.; Nixon, P. R.; Skoug, J. W.; Ju, T. R.; Gao, P.; Topp, E. M.; Patel, M. V. Effect of Formulation Variables on Drug and Polymer Release from HPMC-based Matrix Tablets. Int. J. Pharm. 1996, 142, 53-60.
  •  
  • 26. Bourne, D. W.; Banker, G. S.; Rhodes, C. T. Principles of Drug Absorption. Modern Pharmaceutics; CRC Press: Florida, 2002; pp 67-92.
  •  
  • 27. Dash, S.; Murthy, P. N.; Nath, L.; Chowdhury, P. Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems. Acta Pol. Pharm. 2010, 67, 217-223.
  •  
  • 28. Singhvi, G.; Singh, M. In-vitro Drug Release Characterization Models. Int. J. Pharm. Stud. Res. 2011, 2, 77-84.
  •  
  • 29. Kiortsis, S.; Kachrimanis, K.; Broussali, T.; Malamataris, S. Drug Release from Tableted Wet Granulations Comprising Cellulosic (HPMC or HPC) and Hydrophobic Component. Eur. J. Pharm. Biopharm. 2005, 59, 73-83.
  •  
  • 30. Jeong, K. H.; Woo, H. S.; Kim, C. J.; Lee, K. H.; Jeon, J. Y.; Lee, S. Y.; Kang, J. H.; Lee, S.; Choi, Y. W. Formulation of a Modified-release Pregabalin Tablet Using Hot-melt Coating with Glyceryl Behenate. Int. J. Pharm. 2015, 495, 1-8.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(2): 229-237

    Published online Mar 25, 2022

  • 10.7317/pk.2022.46.2.229
  • Received on Nov 17, 2021
  • Revised on Dec 23, 2021
  • Accepted on Dec 28, 2021

Correspondence to

  • oung Wook Choi

  • College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul 06974, Korea

  • E-mail: ywchoi@cau.ac.kr