Article
  • In Situ Photo-crosslinkable Biodegradable Tissue Adhesive for Wound Healing
  • Hyeseon Lee# , Keum-Yong Seong# , Sodam Kim, Ajeesh Chandrasekharan,
    Dae Youn Hwang, Young Ki Hahn*, **, Moon-Chang Baek**, ***, Jun Lee****,† , and
    Seung Yun Yang

  • Department of Biomaterials Science (BK21 Four Program), College of Natural Resources & Life Science, Pusan National University, Miryang 50463, Korea
    *Department of Biomedical Convergence Science and Technology, School of Convergence,
    Kyungpook National University, Daegu 41566, Korea
    **Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41566, Korea
    ***Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41566, Korea
    ****Department of Oral and Maxillofacial Surgery, School of Dentistry, College of Dentistry,
    Wonkwang University, Iksan 54538, Korea

  • 창상 치유를 위한 생체고분자 기반 광가교형 조직접착제 개발
  • 이혜선# · 성금용# · 김소담 · 아지시찬드라세카란 · 황대연 · 한영기*, ** · 백문창**, *** · 이 준****,† · 양승윤

  • 부산대학교 생명자원과학대학 바이오소재과학과, *경북대학교 융합학부 의생명융합공학과, **경북대학교 의과대학 세포·기질연구소,***경북대학교 의과대학 분자의학교실,****원광대학교 치과대학 구강악안면외과학교실

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Cimador, M.; Castagnetti, M.; Milazzo, M.; Sergio, M.; De Grazia, E. Suture Materials: Do They Affect Fistula and Stricture Rates in Flap Urethroplasties? Urol. Int. 2004, 73, 320-324.
  •  
  • 2. Vote, B. J.; Elder, M. J. Cyanoacrylate Glue for Corneal Perforations: A Description of a Surgical Technique and a Review of the Literature. Clin. Exp. Ophthalmol. 2000, 28, 437-442.
  •  
  • 3. Al-Mubarak, L.; Al-Haddab, M. Cutaneous Wound Closure Materials: An Overview and Update. J. Cutan. Aesthet. Surg. 2013, 6, 178-188.
  •  
  • 4. Artzi, N. Sticking with the Pattern for a Safer Glue. Sci. Transl. Med. 2013, 5, 205ec161.
  •  
  • 5. Edmiston, C. E., Jr.; Krepel, C. J.; Marks, R. M.; Rossi, P. J.; Sanger, J.; Goldblatt, M.; Graham, M. B.; Rothenburger, S.; Collier, J.; Seabrook, G. R. Microbiology of Explanted Suture Segments from Infected and Noninfected Surgical Patients. J. Clin. Microbiol. 2013, 51, 417-421.
  •  
  • 6. Ge, L.; Chen, S. Recent Advances in Tissue Adhesives for Clinical Medicine. Polymers (Basel) 2020, 12, 939.
  •  
  • 7. Bouten, P. J. M.; Zonjee, M.; Bender, J.; Yauw, S. T. K.; van Goor, H.; van Hest, J. C. M.; Hoogenboom, R. The Chemistry of Tissue Adhesive Materials. Prog. Polym. Sci. 2014, 39, 1375-1405.
  •  
  • 8. Edmonson, M. B. Foreign Body Reactions to Dermabond. Am. J. Emerg. Med. 2001, 19, 240-241.
  •  
  • 9. Mehdizadeh, M.; Yang, J. Design Strategies and Applications of Tissue Bioadhesives. Macromol. Biosci. 2013, 13, 271-288.
  •  
  • 10. Anema, J. G.; Morey, A. F.; Harris, R.; MacPhee, M.; Cornum, R. L. Potential Uses of Absorbable Fibrin Adhesive Bandage for Genitourinary Trauma. World J. Surg. 2001, 25, 1573-1577.
  •  
  • 11. Bitton, R.; Josef, E.; Shimshelashvili, I.; Shapira, K.; Seliktar, D.; Bianco-Peled, H. Phloroglucinol-based Biomimetic Adhesives for Medical Applications. Acta Biomater. 2009, 5, 1582-1587.
  •  
  • 12. Lang, N.; Pereira, M. J.; Lee, Y.; Friehs, I.; Vasilyev, N. V.; Feins, E. N.; Ablasser, K.; O’Cearbhaill, E. D.; Xu, C.; Fabozzo, A.; Padera, R.; Wasserman, S.; Freudenthal, F.; Ferreira, L. S.; Langer, R.; Karp, J. M.; Nido, P. J. del. A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects. Sci. Transl. Med. 2014, 6, 218ra6.
  •  
  • 13. Wang, T.; Nie, J.; Yang, D. Dextran and Gelatin Based Photo- crosslinkable Tissue Adhesive. Carbohydr. Polym. 2012, 90, 1428-1436.
  •  
  • 14. Soucy, J. R.; Shirzaei, S. E.; Portillo, L. R.; Diaz, D.; Dias, F.; Weiss, A. S.; Koppes, A. N.; Koppes, R. A.; Annabi, N. Photo- crosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair. Tissue Eng. Part A 2018, 24, 1393-1405.
  •  
  • 15. Shirzaei, S. E.; Kheirkhah, A.; Rana, D.; Sun, Z.; Foulsham, W.; Sheikhi, A.; Khademhosseini, A.; Dana, R.; Annabi, N. Sutureless Repair of Corneal Injuries Using Naturally Derived Bioadhesive Hydrogels. Sci. Adv. 2019, 5, eaav1281.
  •  
  • 16. Taboada, G. M.; Yang, K.; Pereira, M. J. N.; Liu, S. S.; Hu, Y.; Karp, J. M.; Artzi, N.; Lee, Y. Overcoming the Translational Barriers of Tissue Adhesives. Nat. Rev. Mater. 2020, 5, 310-329.
  •  
  • 17. Chandrasekharan, A.; Seong, K.-Y.; Yim, S.-G.; Kim, S.; Seo, S.; Yoon, J.; Yang, S. Y. In situ Photocrosslinkable Hyaluronic Acid-based Surgical Glue with Tunable Mechanical Properties and High Adhesive Strength. J. Polym. Sci. A Polym. Chem. 2019, 57, 522-530.
  •  
  • 18. Kim, S.; Yim, S.-G.; Chandrasekharan, A.; Seong, K.-Y.; Lee, T. W.; Kim, B.; Kim, K.; Choi, S.; Yang, S. Y. On-site Fabrication of Injectable 131I-labeled Microgels for Local Radiotherapy. J. Control Release. 2020, 322, 337-345.
  •  
  • 19. Zhou, M.; Lee, B. H.; Tan, Y. J.; Tan, L. P. Microbial Transglutaminase Induced Controlled Crosslinking of Gelatin Methacryloyl to Tailor Rheological Properties for 3D Printing. Biofabrication. 2019, 11, 025011.
  •  
  • 20. Hong, Y.; Zhou, F.; Hua, Y.; Zhang, X.; Ni, C.; Pan, D.; Zhang, Y.; Jiang, D.; Yang, L.; Lin, Q.; Zou, Y.; Yu, D.; Arnot, D.; Zou, X.; Zhu, L.; Zhang, S.; Ouyang, H. A Strongly Adhesive Hemostatic Hydrogel for the Repair of Arterial and Heart Bleeds. Nat. Commun. 2019, 10, 2060.
  •  
  • 21. Higham, A. K.; Bonino, C. A.; Raghavan, S. R.; Khan, S. A. Photo-activated Ionic Gelation of Alginate Hydrogel: Real-time Rheological Monitoring of the Two-step Crosslinking Mechanism. Soft Matter. 2014, 10, 4990-5002.
  •  
  • 22. Annabi, N.; Zhang, Y.-N.; Assmann, A.; Sani, E. S.; Cheng, G.; Lassaletta, A. D.; Vegh, A.; Dehghani, B.; Ruiz-Esparza, G. U.; Wang, X.; Gangadharan, S.; Weiss, A. S.; Khademhosseini, A. Engineering a Highly Elastic Human Protein-based Sealant for Surgical Applications. Sci. Transl. Med. 2017, 9, eaai7466.
  •  
  • 23. Peng, B.; Lai, X.; Chen, L.; Lin, X.; Sun, C.; Liu, L.; Qi, S.; Chen, Y.; Leong, K. W. Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability. ACS Omega. 2017, 2, 6053-6062.
  •  
  • 24. Moon, Y. J.; Yoon, S.-J.; Koo, J.-H.; Yoon, Y.; Byun, H. J.; Kim, H. S.; Khang, G.; Chun, H. J.; Yang, D. H. β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive. Int. J. Mol. Sci. 2021, 22, 700.
  •  
  • 25. Guo, Y.; Wang, Y.; Zhao, X.; Li, X.; Wang, Q.; Zhong, W.; Mequanint, K.; Zhan, R.; Xing, M.; Luo, G. Snake Extract-laden Hemostatic Bioadhesive Gel Cross-linked by Visible Light. Sci. Adv. 2021, 7, eabf9635.
  •  
  • 26. Bellare, A.; Epperly, M. W.; Greenberger, J. S.; Fisher, R.; Glowacki, J. Development of Tensile Strength Methodology for Murine Skin Wound Healing. MethodsX 2018, 5, 337-344.
  •  
  • 27. Selvaraj, T. K. R.; Thiruselvi, T.; Sailakshmi, G.; Shanmugam, G.; Gnanamani, A. Rejoining of Cut Wounds by Engineered Gelatin-keratin Glue. Biochim. Biophys. Acta. 2013, 1830, 4898.
  •  
  • 28. Snyder, T.; Madhavan, K.; Intrator, I.; Dregalla, R.; Park, D. A Fibrin/Hyaluronic Acid Hydrogel for the Delivery of Mesenchymal Stem Cells and Potential for Articular Cartilage. J. Biol. Eng. 2014, 8, 10.
  •  
  • 29. Zhu. Z.; Wang, Y.-M.; Yang, J.; Luo, X.-S. Hyaluronic Acid: A Versatile Biomaterial in Tissue Engineering. Plast Aesthet Res. 2017, 4, 219-227.
  •  
  • 30. Collins, M. N.; Birkinshaw, C. Hyaluronic Acid Based Scaffolds for Tissue Engineering-A Review. Carbohydr. Polym. 2013, 92, 1262-1279.
  •  
  • 31. Rao, N. V. 22-Hyaluronic Acid-Based Hydrogels for Tissue Engineering. In Biomaterials for Organ and Tissue Regeneration; Vrana, N. E.; Knopf-Marques, H.; Barthes, J.; Woodhead Publishing: Cambridge, 2020; pp 551-565.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(2): 216-222

    Published online Mar 25, 2022

  • 10.7317/pk.2022.46.2.216
  • Received on Nov 11, 2021
  • Revised on Dec 30, 2021
  • Accepted on Jan 5, 2022

Correspondence to

  • Jun Lee**** , and Seung Yun Yang
  • Department of Biomaterials Science (BK21 Four Program), College of Natural Resources & Life Science, Pusan National University, Miryang 50463, Korea
    ****Department of Oral and Maxillofacial Surgery, School of Dentistry, College of Dentistry,
    Wonkwang University, Iksan 54538, Korea

  • E-mail: omslee@wku.ac.kr, syang@pusan.ac.kr