Article
  • Development of Metformin Hydrochloride-Linagliptin Controlled Release Tablet Using Hydrophilic Polymers for Type 2 Diabetes in Asians

  • Sunjae Park*, Pil Yun Kim*, Na Eun Kim*, Youngeun Song*, Ga Young Jeon*, Nomin-Erdene Tumursukh*, Jeong Eun Song*, and Gilson Khang*, **, ***,†

  • *Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    **Department of Polymer Nano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • 아시아인의 제2형 당뇨병 치료를 위한 친수성 고분자를 사용한 메트포르민 염산염-리나글립틴 방출제어형 정제 개발

  • 박선재* · 김필윤* · 김나은* · 송영은* · 전가영* · 투무르수흐너밍에르덴* · 송정은* · 강길선*, **, ***,†

  • *전북대학교 바이오나노융합공학과, **전북대학교 고분자나노공학과, ***전북대학교 고분자융합소재연구소

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
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  • 2. Li, X.; Zhang, Q.; Zhou, X.; Guo, S.; Jiang, S.; Zhang, Y.; Liao, L. The Different Hypoglycemic Effects Between East Asian and Non-Asian Type 2 Diabetes Patients when Treated with SGLT-2 Inhibitors as an add-on Treatment for Metformin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Aging 2021, 13, 12748
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  • 3. Zinman, B., Initial Combination Therapy for Type 2 Diabetes Mellitus: Is It Ready for Prime Time? Am. J. Med. 2011, 124, S19-S34.
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  • 4. Boer, G. A.; Holst, J. J. Incretin Hormones and Type 2 Diabetes-Mechanistic Insights and Therapeutic Approaches. Biology 2020, 9, 473.
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  • 5. Liu, S. C.; Lee, C. C.; Chuang, S. M.; Sun, F. J.; Zeng, Y. H. Comparison of Efficacy and Safety of Empagliflozin vs Linagliptin Added to Premixed Insulin in Patients with Uncontrolled Type 2 Diabetes: A Randomized, Open-label Study. Diabetes & Metabolism 2021, 47, 101184.
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  • 6. Hadi, M. A.; Babu, V. L.; Pal, N. Formulation and Evaluation of Sustained Release Matrix Tablets of Glimepiride Based on Combination of Hydrophilic and Hydrophobic Polymers. J. Appl. Pharm. Sci. 2012, 2, 101-107.
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  • 7. Deb, P. K.; Kokaz, S. F.; Abed, S. N.; Paradkar, A.; Tekade, R. K. Pharmaceutical and Biomedical Applications of Polymers. In Basic Fundamentals of Drug Delivery. Elsevier: Amsterdam, 2019; pp 203-267.
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  • 8. Shanmugam, S. Granulation Techniques and Technologies: Recent Progresses. BioImpacts: BI 2015, 5, 55.
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  • 9. Hansen, J.; Kleinebudde, P. Improving Flowability and Reducing Storage Agglomeration of Metformin Hydrochloride Through QESD Crystallization. Eur. J. Pharm. Biopharm. 2021, 159, 170-176.
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  • 10. Gumieniczek, A.; Berecka-Rycerz, A.; Mroczek, T.; Wojtanowski, K. Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods. Molecules 2019, 24, 4430.
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  • 11. Ozeki, T.; Yuasa, H.; Kanaya, Y. Controlled Release from Solid Dispersion Composed of Poly(ethylene oxide)-Carbopol® Interpolymer Complex with Various Cross-Linking Degrees of Carbopol®. J. Control. Release 2000, 63, 287-295.
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  • 12. Fliszar, K. A.; Foster, N. Examination of Metformin Hydrochloride in a Continuous Dissolution/HDM System. Int. J. Pharm. 2008, 351, 127-132.
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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(2): 159-164

    Published online Mar 25, 2022

  • 10.7317/pk.2022.46.2.159
  • Received on Oct 13, 2021
  • Revised on Dec 7, 2021
  • Accepted on Dec 14, 2021

Correspondence to

  • Gilson Khang

  • *Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    **Department of Polymer Nano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • E-mail: gskhang@jbnu.ac.kr