Article
  • Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters

  • Rukiye Sevinç Özakar  and Emrah Özakar†

  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

  • 품질관리 향상을 위한 다양한 생체고분자의 영향과 동결건조 부유약제의 특성 분석

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Veronovski, A.; Tkalec, G.; Knez, Z.; Novak, Z. Characterisation of Biodegradable Pectin Aerogels and Their Potential Use as Drug Carriers. Carbohyd. Polym. 2014, 113, 272-278.
  •  
  • 2. Jindal, S.; Jindal, K.; Das Gupta, G.; Garg, R.; Awasthi, R. Gastroretentive Floating Tablets: An Investigation of Excipients Effect on Tablet Properties. Marmara. Pharm. J. 2016, 20, 100-110.
  •  
  • 3. Wang, S.; Wen, H. Y.; Li, P. F.; Cui, M. S.; Sun, W. L.; Wang, H. Y.; Liu, H. F.; Li, S. Y.; Pan, W. S.; Yang, X. G. Formulation and Evaluation of Gastric-Floating Controlled Release Tablets of Ginkgolides. J. Drug. Deliv. Sci. Tec. 2019, 51, 7-17.
  •  
  • 4. Kim, J. Y.; Kim, S. H.; Rhee, Y. S.; Park, C. W.; Park, E. S. Preparation of Hydroxypropylmethyl Cellulose-Based Porous Matrix for Gastroretentive Delivery of Gabapentin Using the Freeze-Drying Method. Cellulose 2013, 20, 3143-3154.
  •  
  • 5. Kim, J. Y.; Seo, J. W.; Rhee, Y. S.; Park, C. W.; Park, E. S. Freeze-Dried Highly Porous Matrix as a New Gastroretentive Dosage Form for Ecabet Sodium: In Vitro and In Vivo Characterizations. J. Pharm. Sci.-Us. 2014, 103, 262-273.
  •  
  • 6. Patil, H.; Tiwari, R. V.; Repka, M. A. Recent Advancements in Mucoadhesive Floating Drug Delivery Systems: A Mini-review. J. Drug. Deliv. Sci. Tec. 2016, 31, 65-71.
  •  
  • 7. Shishu; Gupta, N.; Aggarwal, N. Stomach-specific Drug Delivery of 5-fluorouracil Using Floating Alginate Beads. AAPS Pharmscitech 2007, 8, 48.
  •  
  • 8. Awasthi, R.; Kulkarni, G. T. Decades of Research in Drug Targeting to the Upper Gastrointestinal Tract Using Gastroretention Technologies: Where Do We Stand? Drug. Deliv. 2016, 23, 378-394.
  •  
  • 9. Swain, R. P.; Nagamani, A.; Shankar, P. U. Formulation and Evaluation of Gastro-bilayer Floating Tablets of Ezetimibe as Immediate Release Layer and Atenolol as Sustained Release Layer. Indian. J. Pharm. Educ. 2019, 53, S93-S103.
  •  
  • 10. Tripathi, J.; Thapa, P.; Maharjan, R.; Jeong, S. H. Current State and Future Perspectives on Gastroretentive Drug Delivery Systems. Pharmaceutics 2019, 11, 193.
  •  
  • 11. Arora, S.; Ali, J.; Ahuja, A.; Khar, R. K.; Baboota, S. Floating Drug Delivery Systems: A Review. AAPS Pharmscitech 2005, 6, E372-E390.
  •  
  • 12. Chinthaginjala, H.; Barghav, G. C.; Reddy, C. M.; Pradeepkumar, B.; Ahad, H. A. Formulation and In Vitro Evaluation of Floating Tablets of Dicloxacillin Sodium Using Different Polymers. J. Young Pharm. 2019, 11, 247-253.
  •  
  • 13. Prajapati, V. D.; Jani, G. K.; Khutliwala, T. A.; Zala, B. S. Raft Forming System-An Upcoming Approach of Gastroretentive Drug Delivery System. J. Control. Release. 2013, 168, 151-165.
  •  
  • 14. Singh, B. N.; Kim, K. H. Floating Drug Delivery Systems: An Approach to Oral Controlled Drug Delivery via Gastric Retention. J. Control. Release. 2000, 63, 235-259.
  •  
  • 15. Prajapati, S. T.; Patel, L. D.; Patel, C. N. Polymers for Floating Drug Delivery System. Syst. Rev. Pharm. 2011, 2, 1-7.
  •  
  • 16. Kamel, S.; Ali, N.; Jahangir, K.; Shah, S. M.; El-Gendy, A. A. Pharmaceutical Significance of Cellulose: A Review. Express Polym. Lett. 2008, 2, 758-778.
  •  
  • 17. Li, C. L.; Martini, L. G.; Ford, J. L.; Roberts, M. The Use of Hypromellose in Oral Drug Delivery. J. Pharm. Pharmacol. 2005, 57, 533-546.
  •  
  • 18. Iglesias, N.; Galbis, E.; Romero-Azogil, L.; Benito, E.; Lucas, R.; Garcia-Martin, M. G.; de-Paz, M. V. In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations. Pharmaceutics 2020, 12, 636.
  •  
  • 19. Hariyadi, D. M.; Islam, N. Current Status of Alginate in Drug Delivery. Adv. Pharm. Pharm. Sci. 2020, 2020, 8886095.
  •  
  • 20. Siow, C. R. S.; Wan Sia Heng, P.; Chan, L. W. Application of Freeze-Drying in the Development of Oral Drug Delivery Systems. Expert. Opin. Drug. Del. 2016, 13, 1595-1608.
  •  
  • 21. Ahmed, T. A.; El-Say, K. M.; Hosny, K. M.; Aljaeid, B. M. Development of Optimized Self-Nanoemulsifying Lyophilized Tablets (SNELTs) to Improve Finasteride Clinical Pharmacokinetic Behavior. Drug. Dev. Ind. Pharm. 2018, 44, 652-661.
  •  
  • 22. Zhao, S.; Lv, Y.; Zhang, J. B.; Wang, B.; Lv, G. J.; Ma, X. J. Gastroretentive Drug Delivery Systems for the Treatment of Helicobacter pylori. World J. Gastroenterol. 2014, 20, 9321-9329.
  •  
  • 23. Nishi, K. K.; Antony, M.; Jayakrishnan, A. Synthesis and Evaluation of Ampicillin-conjugated Gum Arabic Microspheres for Sustained Release. J. Pharm. Pharmacol. 2007, 59, 485-493.
  •  
  • 24. Prasanthi, N. L.; Harshita, Y.; Manikiran, S. S.; Ramarao, N. Design and Development of Gastroretentive Tablets of Coccinia grandis leaf extract for treating Helicobacter pylori infection. Asian J. Pharm. 2019, 13, 184-191.
  •  
  • 25. Pawar, H. A.; Gharat, P. R.; Dhavale, R. V.; Joshi, P. R.; Rakshit, P. P. Development and Evaluation of gastroretentive Floating Tablets of an Antihypertensive Drug Using Hydrogenated Cottonseed Oil. ISRN Pharm. 2013, 2013, 137238.
  •  
  • 26. Abernethy, D. R; The United States Pharmacopeia-National Formulary (USP30-NF25); The United States Pharmacopeial Convention Inc.: Rockville, 2007; p 1101.
  •  
  • 27. Jagdale, S. C.; Patil, S.; Kuchekar, B. S. Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydro- chloride. Comput. Math. Method M 2013, 2013, 625729.
  •  
  • 28. El-Zahaby, S. A.; Kassem, A. A.; El-Kamel, A. H. Design and Evaluation of Gastroretentive Levofloxacin Floating Mini-Tablets-In-Capsule System for Eradication of Helicobacter pylori. Saudi. Pharm. J. 2014, 22, 570-579.
  •  
  • 29. Ek, M.; the European Pharmacopoeia, 8th Edition; the European Directorate for the Quality of Medicines & HealthCare of the Council of Europe (EDQM): Strasbourg, 2013; pp 357-359.
  •  
  • 30. Pawar, H. A.; Dhavale, R. Development and Evaluation of Gastroretentive Floating Tablets of an Antidepressant Drug by Thermoplastic Granulation Technique. Beni Suef Univ. J. Basic Appl. Sci. 2014, 3, 122-132.
  •  
  • 31. Costa, P.; Manuel, J.; Lobo, S. Modeling and Comparison of Dissolution Profiles. Eur. J. Pharm. Sci. 2001, 13, 123-133.
  •  
  • 32. Sreedharan, S. M.; Singh, R. Ciprofloxacin Functionalized Biogenic Gold Nanoflowers as Nanoantibiotics Against Pathogenic Bacterial Strains. Int. J. Nanomed. 2019, 14, 9905-9916.
  •  
  • 33. Vo, A. Q.; Feng, X.; Morott, J. T.; Pimparade, M. B.; Tiwari, R. V.; Zhang, F.; Repka, M. A. A Novel Floating Controlled Release Drug Delivery System Prepared by Hot-Melt Extrusion. Eur. J. Pharm. Biopharm. 2016, 98, 108-121.
  •  
  • 34. Koca, M.; Özakar, E.; Sevinç Özakar, R. Triiyodoanilin’in Sentezlenmesi, Nanosüspansiyonlarının Hazırlanması, İn Vitro Karakterizasyonu ve Radyokontrast Özelliklerinin İncelenmesi. J. Fac. Pharm. Ankara 2021, 45, 264-283.
  •  
  • 35. Gulen, B.; Demircivi, P. Synthesis and Characterization of Montmorillonite/ciprofloxacin/TiO2 Porous Structure for Controlled Drug Release of Ciprofloxacin Tablet with Oral Administration. Appl. Clay Sci. 2020, 197.
  •  
  • 36. Shoukri, R. A.; Ahmed, I. S.; Shamma, R. N. In Vitro and In Vivo Evaluation of Nimesulide Lyophilized Orally Disintegrating Tablets. Eur. J. Pharm. Biopharm. 2009, 73, 162-171.
  •  
  • 37. Rahamathulla, M.; Hani, U.; Alqahtani, A.; Gangadharappa, H. V.; Begum, M. Y.; Jaffer, M.; Osmani, R. A. M.; Chidambaram, K.; Moin, A.; Shankar, S. J. 23 Factorial Design and Optimization of Effervescent Floating Matrix Tablet of Neratinib. J. Pharm. Innov. [Online early access]. DOI: 10.1007/s12247-021-09569-y. Published Online: June 1, 2021. https://doi.org/10.1007/s12247-021-09563-4 (accessed Jan 28, 2022)
  •  
  • 38. Williams, B. B.; Gidley, J. L.; Guin, J. A.; Schechter, R. S. Characterization of Liquid-Solid Reactions. Hydrochloric Acid-Calcium Carbonate Reaction. Ind. Eng. Chem. Fundamen. 1970, 9, 589-596.
  •  
  • 39. Berardi, A.; Bauhuber, S.; Sawafta, O.; Warnke, G. Alginates as Tablet Disintegrants: Understanding Disintegration Mechanisms and Defining Ranges of Applications. Int. J. Pharmaceut. 2021, 601.
  •  
  • 40. Del Gaudio, P.; Colombo, P.; Colombo, G.; Russo, P.; Sonvico, F. Mechanisms of Formation and Disintegration of Alginate Beads Obtained by Prilling. Int. J. Pharmaceut. 2005, 302, 1-9.
  •  
  • 41. Mandal, S.; Basu, S. K.; Sa, B. Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method. AAPS Pharmscitech 2009, 10, 1348-1356.
  •  
  • 42. Jin, S. G.; Yousaf, A. M.; Kim, K. S.; Kim, D. W.; Kim, D. S.; Kim, J. K.; Yong, C. S.; Youn, Y. S.; Kim, J. O.; Choi, H. G. Influence of Hydrophilic Polymers on Functional Properties and Wound Healing Efficacy of Hydrocolloid Based Wound Dressings. Int. J. Pharmaceut. 2016, 501, 160-166.
  •  
  • 43. Hou, L.; Wu, P. Exploring the Hydrogen-bond Structures in Sodium Alginate Through Two-Dimensional Correlation Infrared Spectroscopy. Carbohydr. Polym. 2019,205, 420-426.
  •  
  • 44. Ciolacu, D. E. Structure-Property Relationships in Cellulose-Based Hydrogels. In Cellulose-Based Superabsorbent Hydrogels; Mondal, I. H., Ed.; Springer: Cham, 2018; pp 1-32.
  •  
  • 45. Raza, A.; Shen, N.; Li, J. H.; Chen, Y. S.; Wang, J. Y. Formulation of Zein Based Compression Coated Floating Tablets for Enhanced Gastric Retention and Tunable Drug Release. Eur. J. Pharm. Sci. 2019, 132, 163-173.
  •  
  • 46. Arza, R. A. K.; Gonugunta, C. S. R.; Veerareddy, P. R. Formulation and Evaluation of Swellable and Floating Gastroretentive Cipro- floxacin Hydrochloride Tablets. AAPS Pharmscitech 2009, 10, 220-226.
  •  
  • 47. Wongsasulak, S.; Puttipaiboon, N.; Yoovidhya, T. Fabrication, Gastromucoadhesivity, Swelling, and Degradation of Zein-Chitosan Composite Ultrafine Fibers. J. Food Sci. 2013, 78, N926-N935.
  •  
  • 48. Vanitha, K.; Varma, M.; Ramesh, A. Floating Tablets of Hydralazine Hydrochloride: Optimization and Evaluation. Braz J. Pharm. Sci. 2013, 49, 811-819.
  •  
  • 49. Shinde, A. J.; Patil, M. S.; More, H. N. Formulation and Evaluation of an Oral Floating Tablet of Cephalexin. Indian J. Pharm. Educ. 2010, 44, 243-252.
  •  
  • 50. Raza, A.; Bukhari, N. I.; Karim, S.; Hafiz, M. A.; Hayat, U. Floating Tablets of Minocycline Hydrochloride: Formulation, In-Vitro Evaluation and Optimization. Futur. J. Pharm. Sci. 2017, 3, 131-139.
  •  
  • 51. Patel, V. R.; Amiji, M. M. pH-Sensitive Swelling and Drug-Release Properties of Chitosan Poly(ethylene oxide) Semi-Interpenetrating Polymer Network. Acs Sym. Ser. 1996, 627, 209-220.
  •  
  • 52. Marchais, H.; Cayzeele, G.; Legendre, J. Y.; Skiba, M.; Arnaud, P. Cross-linking of Hard Gelatin Carbamazepine Capsules: Effect of Dissolution Conditions on In Vitro Drug Release. Eur. J. Pharm. Sci. 2003, 19, 129-132.
  •  
  • 53. Abou Youssef, N. A. H.; Kassem, A. A.; El-Massik, M. A. E.; Boraie, N. A. Development of Gastroretentive Metronidazole Floating Raft System for Targeting Helicobacter pylori. Int. J. Pharmaceut. 2015, 486, 297-305.
  •  
  • 54. Young, C. R.; Dietzsch, C.; McGinity, J. W. Compression of Controlled-Release Pellets Produced by a Hot-Melt Extrusion and Spheronization Process. Pharm. Dev. Technol. 2005, 10, 133-139.
  •  
  • 55. Bizarro, M.; Rodil, S. E. Physicochemical Characterization of Photocatalytic Materials. In Photocatalytic Semiconductors: Synthesis,Characterization, and Environmental Applications, Medina-Ramírez, A.; Hernández.-Ramírez, A. Ed. Springer: Cham, 2015; p 127.
  •  
  • 56. Gandolpho Tótoli, E.; Regina Nunes Salgado, H. Development and Validation of the Quantitative Analysis of Ampicillin Sodium in Powder for Injection by Fourier-transform Infrared Spectroscopy (FTIR). Physical Chemistry 2013, 2, 103-108.
  •  
  • 57. Queiroz, A. C.; Santos, J. D.; Monteiro, F. J. Development of a System to Adsorb Drugs Onto Calcium Phosphate Materials. J. Mater Sci. Mater Med. 2005, 16, 641-646.
  •  
  • 58. Murei, A.; Ayinde, W. B.; Gitari, M. W.; Samie, A. Functionalization and Antimicrobial Evaluation of Ampicillin, Penicillin and Vancomycin with Pyrenacantha grandiflora Baill and Silver Nanoparticles. Sci. Rep. 2020, 10, 11596.
  •  
  • 59. Rogowska, A.; Rafinska, K.; Pomastowski, P.; Walczak, J.; Railean-Plugaru, V.; Buszewska-Forajta, M.; Buszewski, B. Silver Nanoparticles Functionalized with Ampicillin. Electrophoresis 2017, 38, 2757-2764.
  •  
  • 60. Awasthi, R.; Kulkarni, G. T.; Pawar, V. K.; Garg, G. Optimization Studies on Gastroretentive Floating System Using Response Surface Methodology. AAPS Pharmscitech 2012, 13, 85-93.
  •  
  • 61. Bajpai, S. K.; Shah, F. F.; Bajpai, M.; Jadaun, M.; Jyotishi, P. Dynamic Release of Amoxicillin from Orally Dissolving Film (ODF) Composed of Casein and Sodium alginate. J. Drug. Res. Dev. 2017, 3, DOI: 10.16966/2470-1009.134.
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  • Polymer(Korea) 폴리머
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This Article

  • 2022; 46(2): 145-158

    Published online Mar 25, 2022

  • 10.7317/pk.2022.46.2.145
  • Received on Oct 5, 2021
  • Revised on Nov 24, 2021
  • Accepted on Dec 19, 2021

Correspondence to

  • Rukiye Sevinç Özakar, and Emrah Özakar

  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

  • E-mail: emrahozakar@atauni.edu.tr