Article
  • Design of Naproxen Sodium Formulations with Improved Solubility by Wet Granulation

  • Seong Won Lee# , Hun Hwi Cho# , Jin Woo Kim, Nam Yeong Kim, Pil Yun Kim, Cheol Ui Song, Won Chan Lee, Jeong Min Choi, Jeong Eun Song, and Gilson Khang†

  • Department of Bionanotechnology and Bio-Convergence Engineering, Department of PolymerNano Science & Technology and Polymer Materials Fusion Research Center, Chonbuk National University,
    567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • 습식 과립을 통해 용해도가 개선된 나프록센 나트륨 제형 설계

  • 이성원# · 조훈휘# · 김진우 · 김남영 · 김필윤 · 송철의 · 이원찬 · 최정민 · 송정은 · 강길선†

  • 전북대학교 바이오나노융합공학과, 고분자나노공학과, 고분자융합소재연구소

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Wolfe, F.; King, S. X.; Watson, D. J. Gastrointestinal Symptoms and Health-related Quality of Life in Patients with Arthritis. J. Rheumatol. 2000, 27, 1373-1378.
  •  
  • 2. Dewitt, D. L.; Meade, E. A.; Smith, W. L. PGH Synthase Isoenzyme Selectivity: The Potential for Safer Nonsteroidal Antiinflammatory Drugs. Am. J. Med. 1993, 95, 40S-44S.
  •  
  • 3. Vane, J. Towards a Better Aspirin. Nature 1994, 367, 215-216.
  •  
  • 4. Pairet, M.; Engelhardt, G. Distinct Isoforms (COX-1 and COX-2) of Cyclooxygenase: Possible Physiological and Therapeutic Implications. Fundam. Clin. Pharmacol. 1996, 10, 1-17.
  •  
  • 5. Sarkar, K.; Sadat, S. M. A.; Islam, M. S.; Jalil, R. Study of Ethyl Cellulose Based Sustained Release Microspheres of Naproxen Sodium. Dhaka Univ. J. Pharm. Sci. 2011, 10, 123-129.
  •  
  • 6. Savaroglu, G.; Caglar, M.; Ildaser, A. C.; Hur, E.; Ildaser, S. The Effect of Sonication Time on the Surface Morphology and Dissolubility of Naproxen Sodium Powders. Appl. Surf. Sci. 2019, 492, 66-72.
  •  
  • 7. Shah, S. U.; Shah, K. U.; Jan, S. U.; Ahamad, K.; Rehman, A. U.; Hussain, A.; Khan, G. M. Formulation and In Vitro Evaluation of Ofloxacin-Ethocel Controlled Release Matrix Tablets Prepared by Wet. Pak. J. Pharm. Sci. 2011,24, 255-261.
  •  
  • 8. Mandal, S.; Basu, S. K.; Sa, B. Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method. AAPS PharmSciTech. 2009, 10, 1348-1356.
  •  
  • 9. Martino, P. D.; Malaj, L.; Censi, R.; Martelli, S. Physico-Chemical and Technological Properties of Sodium Naproxen Granules Prepared in a High-Shear Mixer-Granulator. J. Pharm. Sci. 2008, 97, 5263-5273.
  •  
  • 10. Suzuki, H.; Sunada, H. Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers. Chem. Pharm. Bull. 1998, 46, 482-487.
  •  
  • 11. Kirk, J. H.; Dann, S. E.; Blatchford, C. G. Lactose: A Definitive Guide to Polymorph Determination. Int. J. Pharm. 2007, 334, 103-114.
  •  
  • 12. Sharma, P.; Chawla, A.; Pawar, P. Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen. Sci. World J. 2013, 2013, 654829.
  •  
  • 13. Tang, B.; Wang, J.; Wang, Q.; Xiao, Y.; Huang, Y.; Liao, X.; Li, H. Calcium(II)-Naproxen Complex: Synthesis, Characterization, and Interaction with Human Serum Albumin. Spectrosc. Lett. 2016, 49, 404-412.
  •  
  • 14. Omkaram, I.; Chakradhar, R. P. S.; Rao, J. L. EPR, Optical, Infrared and Raman Studies of VO2+ Ions in Polyvinylalcohol Films. Physica B 2007, 388, 318-325.
  •  
  • 15. Olshavsky, M. A.; Allcock, H. R. Synthesis of CdS Nanoparticles in Solution and in a Polyphosphazene Matrix. Chem. Mater. 1997, 9, 1367-1376.
  •  
  • 16. Goddeeris, C.; Mooter, G. V. D. Free Flowing Solid Dispersions of the Anti-HIV Drug UC 781 with Poloxamer 407 and a Maximum Amount of TPGS 1000: Investing the Relationship between Physicochemical Characteristics and Dissolution Behaviour. Eur. J. Pharm. Sci. 2008, 35, 104-113.
  •  
  • 17. Chen, Y.; Liu, S.; Wang, G. Kinetics and Adsorption Behavior of Carboxymethyl Starch on α-Alumina in Aqueous Medium. J. Colloid Interface Sci. 2006, 303, 380-387.
  •  
  • 18. Tan, J.; Balasubramanian, B. M. Particle Size Measurements and Scanning Electron Microscopy (SEM) of Cocoa Particles Refined/Conched by Conical and Cylindrical Roller Stone Melangers. J. Food Eng. 2017, 212, 146-153.
  •  
  • 19. Roth, G. A.; Neu-Baker, N. M.; Brenner, S. A. SEM Analysis of Particle Size During Conventional Treatment of CMP Process Wastewater. Sci. Total Environ. 2015, 508, 1-6.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2021; 45(3): 346-352

    Published online May 25, 2021

  • 10.7317/pk.2021.45.3.346
  • Received on Sep 14, 2020
  • Revised on Dec 5, 2020
  • Accepted on Jan 25, 2021

Correspondence to

  • Gilson Khang

  • Department of Bionanotechnology and Bio-Convergence Engineering, Department of PolymerNano Science & Technology and Polymer Materials Fusion Research Center, Chonbuk National University,
    567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • E-mail: gskhang@jbnu.ac.kr