Article
  • Copolymerization of 1-(2-Carbomethoxy acryloyl)-5-fluorouracil with Vinyl Acetate, Methyl Methacrylate, and Styrene
  • Lee NJ, Ha CS, Cho WJ
  • 1-(2-카르보메톡시아크릴로일)-5-플루오르우라실과 초산비닐, 메틸메타크릴레이트 및 스티렌과의 공중합
  • 이능주, 하창식, 조원제
Abstract
Copolymerizations of 1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU) with vinyl acetate. methyl methacrylate, and styrene were carried out with 2,2'-azobisisobutyronitrile in tetrahydrofuran at 50℃. The copolymer compositions were determined by quantitative infrared(IR) analysis. The monomer reactivity ratios, r1 and r2 were determined by the Kelen-Tudos method. The values of r1 and r2 for each monomer pair were as follows; r1(CMAFU)=0.04 and r2(VAc)=0.19 ; r1 (CMAFU)=0.01 and r2(MMA)=32.11 ; r1(CMAFU)=0.01 and r2(St)=7.65. These values imply that the copolymerizations were significantly affected by the steric hindrance of CMAFU. Toxicity of 5-fluorouracil(5-FU), CMAFU and its copolymers obtained for this work was tested in Drosophila melanogaster. It was observed that the toxicity decreased in the order of 5-FU> copolymer>CMAFU.

1-(2-Carbomethoxyacryloyl)-5-fluorouracil(CMAFU)과 초산비닐(VAc), 메틸메타크릴레이트(MMA) 및 스티렌을 tetrahydrofuran을 용매로 사용하여 50℃에서 라디칼 공중합을 하였다. 공중합체내의 단량체조성은 공중합체의 IR 스펙트럼으로부터 정량분석하여 구하였다. Kelen-Tudos법에 의해 구한 각각의 단량체 반응성비의 값은 r1(CMAFU)= 0.04 r2(VAc)=0.19 ; r1 (CMAFU)=0.01 r2 (MMA)=32.11 ; r1(CMAFU)=0.01과 r2(St)=7.65이었다. 얻어진 단량체 반응성비의 값들로부터 CMAFU와 VAc, MMA 및 St 공중합에서 CMAFU의 입체장애 효과가 큰 영향을 미치는 것을 알 수 있었다. 노랑초파리(Drosophila melanogaster)를 이용하여 5-플루오르우라실(5-FU), 합성한 CMAFU 단량체 및 공중합체들의 독성을 조사한 결과, 5-FU>공중합체>CMAFU순으로 독성이 감소하였다.

Keywords:

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1991; 15(2): 211-217

    Published online Apr 25, 1991

  • 10.7317/pk.
  • Received on Nov 30, -0001
  • Revised on Nov 30, -0001
  • Accepted on Nov 30, -0001

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