Copolymerizations of 1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU) with vinyl acetate. methyl methacrylate, and styrene were carried out with 2,2'-azobisisobutyronitrile in tetrahydrofuran at 50℃. The copolymer compositions were determined by quantitative infrared(IR) analysis. The monomer reactivity ratios, r₁ and r₂ were determined by the Kelen-Tudos method. The values of r₁ and r₂ for each monomer pair were as follows; r₁(CMAFU)=0.04 and r₂(VAc)=0.19 ; r₁ (CMAFU)=0.01 and r₂(MMA)=32.11 ; r₁(CMAFU)=0.01 and r₂(St)=7.65. These values imply that the copolymerizations were significantly affected by the steric hindrance of CMAFU. Toxicity of 5-fluorouracil(5-FU), CMAFU and its copolymers obtained for this work was tested in Drosophila melanogaster. It was observed that the toxicity decreased in the order of 5-FU> copolymer>CMAFU.

1-(2-Carbomethoxyacryloyl)-5-fluorouracil(CMAFU)과 초산비닐(VAc), 메틸메타크릴레이트(MMA) 및 스티렌을 tetrahydrofuran을 용매로 사용하여 50℃에서 라디칼 공중합을 하였다. 공중합체내의 단량체조성은 공중합체의 IR 스펙트럼으로부터 정량분석하여 구하였다. Kelen-Tudos법에 의해 구한 각각의 단량체 반응성비의 값은 r₁(CMAFU)= 0.04 r₂(VAc)=0.19 ; r₁ (CMAFU)=0.01 r₂ (MMA)=32.11 ; r₁(CMAFU)=0.01과 r₂(St)=7.65이었다. 얻어진 단량체 반응성비의 값들로부터 CMAFU와 VAc, MMA 및 St 공중합에서 CMAFU의 입체장애 효과가 큰 영향을 미치는 것을 알 수 있었다. 노랑초파리(Drosophila melanogaster)를 이용하여 5-플루오르우라실(5-FU), 합성한 CMAFU 단량체 및 공중합체들의 독성을 조사한 결과, 5-FU>공중합체>CMAFU순으로 독성이 감소하였다.

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