Blood compatibility have been studied for copoly (urethane-g-γ-methyl-L- gluta-mate). Copolymer was synthesized by ring opening anionic polymerization of γ- MLG NCA with amine substituted polyurethane. Amine substituted polyurethane was made from sodium hydride and p-bromoaniline in dimethylformamide at 0℃. Reaction site of polyurethane was controlled by sodium hydride. In order to adjust the grafted chain length, the amount cf γ-MLG NCA added was controlled. Microsphere column, Lee-White and film depositing methods were used for the evaluation of blood compatibility. The behavior of platelet on the polymer surfaces was investigated by scanning electron microscope and average number of platelet was measured by Coulter Counter. The contact angle and the clotting time of samples were investigated in order to examine the blood compatibility of copolymer.

Copoly(urethane-g-γ-methyl-L-glutamate)에 대한 혈액적합성을 검토하였다. 공중합체는 γ-methyl-L-glutamate N-carboxyanhydride(γ-MLG NCA)를 아민기가 치환된 폴리우레탄으로 개환중합하여 합성하였다. 아민치환폴리우레탄은 dimethylformamide (DMF)용매, 0℃에서 NaH와 p-bromoaniline으로 합성하였다. 폴리우레탄의 반응부분의 수는 NaH양으로 조절하였다. 그라프트쇄의 길이는 γ-MLG NCA양으로 조절하였다. 혈액적합성 평가는 microsphere column법, Lee-White법 그리고 film depositing법으로 하였다. 고분자표면에서의 혈소판의 점착거동은 주사전자현미경으로 조사하였고, 유출된 잔유혈소판 수는 Coulter Counter로 측정하였다. 공중합체의 혈액적합성을 검토하기 위해 접촉각과 혈액응고시간을 측정하였다.

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