Article
  • Chitosan-based Skin Substitute ; Ⅰ. Synthesis and Properties of Polyelectrolyte Complex Consisting of Sulfonated Chitosan and Chitosan
  • Kim KY, Min DS, Chung HS
  • Chitosan계 인공피부의 개발 ; Ⅰ. Chitosan과 Sulfon화 Chitosan으로 된 고분자 전해질 복합체의 합성과 성질
  • 김계용, 민동선, 정호삼
Abstract
The possibility of polyelectrolyte complex. which wart prepared from chitosan and sulfonated chitosat as a skin substitute was evaluated by measuring the tensile strength and elongation under wet state, water content, water vapor transmittance rate, permeability of oxygen and biodegradability. The polyelectrolyte complex was dissolved in a quaternary solvent mixture(NaBr/water/DMF/DMSO=10:33:20:37). Water vapor transmittance rate was 400-450g/m2day like that of the normal skin, the coefficient of oxygen permeability was 1.3-6.2×10cm3(STP)cm/cm2sec cmHg. The water absorption was 94-150%, and the tensile strength of 0.4-0.6 kg/mm2 was lower than that of the normal skin. From the result of the biodegradability by lysozyme, the biodegradation rate was fast at the initial state but it was slow after 10-12 days. The critical surface tension was 25.7-27.5dyne/cm. From the results obtained in this study, polyelectrolyte complex which was prepared from chitosan and sulfonated chitosan was found to satisfy most of the basic properties of a skin substitute.

Chitosan과 술폰화 chitosan으로 된 고분자전해질복합체를 합성하여 인공피부로서의 이용가능성을 알아보기 위한 기초적인 물성을 검토하였다. chitosan과 술폰화 chitosan의 혼합비율, 수증기투과성, 산소투과성, 흡수율 및 습윤시 인장강도와 신장율 그리고 생체분해성에 대해 조사하였다. 그 결과 수증기투과성은 400∼500g/m2·day, 산소투과성은 1.3∼6.2×10-8cm3(STP)cm/cm2·sec·cmHg이었으며 흡수율은 94∼150%이었다. 습윤시의 인장강도와 신장율은 각각 0.6∼0.4kg/mm2, 59∼77%이었다. Iysozyme에 의한 분해실험으로부터 10∼12일 이후에는 거의 분해하지 않음을 알 수 있었다. 또한 접촉각 측정결과 임계표면장력 값이 25.7∼27.5dyne/cm이었다. 이상의 실험결과로부터 인공피부로서 요구되는 기본적인 물성값을 대부분 만족하고 있었다.

Keywords:

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1988; 12(3): 234-240

    Published online May 25, 1988

  • 10.7317/pk.
  • Received on Nov 30, -0001
  • Revised on Nov 30, -0001
  • Accepted on Nov 30, -0001

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