Article
  • Interaction between Heparin and Acridine Orange
  • Cho CS, Kang SW
  • Heparin 과 Acridine Orange 와의 상호작용
  • 조종수, 강성우
Abstract
The interaction between heparin and acridine orange(AO) was studied by circular dichroism(CD). absorption and fluorescence spectra measurements. The strength of the dye-dye interaction (stacking tendency) between acridine orange cations bound to neighboring sites on the heparin was measured in terms of a ,stacking coefficient(K) and other method (β/α) derived from the spectrum of the bound dye. As the P/D molar ratio was increased, α band of at AO at 492nm was decreased while β bared at 470nm and γ band at 450nm were increased. The most stacking of AO was obtained at the P/D molar ratio of 25. An extrinsic optical activity was induced in the region corresponding to the absorption bands of AO when the dye became bound to the heparin. The magnitude of the molar ellipticity of heparin-AO complex was dependent on the P/D ratios. The conformational change of heparin occurred by forming complex with acridine orange.

Keywords:

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 1987; 11(2): 122-126

    Published online Apr 25, 1987

  • 10.7317/pk.
  • Received on Nov 30, -0001
  • Revised on Nov 30, -0001
  • Accepted on Nov 30, -0001

Correspondence to

  • E-mail: