Article
  • Highly Porous Biocomposite Scaffolds Fabricated by Chitosan/Alginate/Diatom for Tissue Engineering
  • Yusuf Özcan , Dicle Erden Gönenmiş, Esranur Kızılhan, and Cem Gök*

  • Department of Biomedical Engineering, Pamukkale University, 20070, Denizli, Turkey
    *Department of Metallurgical and Material Engineering, Pamukkale University, 20070, Denizli, Turkey

  • Chitosan/Alginate/Diatom을 이용한 조직공학용 다공성 세포지지체 연구
  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

Tissue scaffolds based composite material have attracted great attention in the field of bone tissue engineering. Therefore, researchers are looking for new materials to be used for composite tissue scaffolding. We aimed to produce the effect of high porous and non-toxic scaffolds as hydrogels with two different contents using chitosan, alginate and diatom. Beads were made from alginate and alginate/diatom hydrogels and additionally coated in dilute chitosan solution. Obtained alginate-chitosan (AC) and alginate/diatom-chitosan (ADC) beads were lyophilized. High-porous AC scaffold and both high-porous and nano-porous ADC scaffold were examined in terms of density, porosity, swelling tests and morphologic, chemical, cytotoxic analysis. In this study, high porosity with approximately 450 μm pore size was found for AC and ADC scaffolds. The average pore size of diatom in ADC was acquired as 280 nm. Moreover, AC and ADC did not show any cytotoxic effects on HEK293 cells. Our results clearly indicated that scaffolds have an alternative potential in the field of tissue engineering.


Keywords: biocomposite, diatom, chitosan, alginate, scaffold, tissue engineering.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(4): 455-462

    Published online Jul 25, 2022

  • 10.7317/pk.2022.46.4.455
  • Received on Jan 7, 2021
  • Revised on Mar 17, 2022
  • Accepted on Apr 25, 2022

Correspondence to

  • Yusuf Özcan
  • Department of Biomedical Engineering, Pamukkale University, 20070, Denizli, Turkey

  • E-mail: ozcan@pau.edu.tr